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Author (up) Zanquetta, M.M.; Correa-Giannella, M.L.; Monteiro, M.B.; Villares, S.M. url  doi
openurl 
  Title Body weight, metabolism and clock genes Type Journal Article
  Year 2010 Publication Diabetology & Metabolic Syndrome Abbreviated Journal Diabetol Metab Syndr  
  Volume 2 Issue Pages 53  
  Keywords Human Health  
  Abstract Biological rhythms are present in the lives of almost all organisms ranging from plants to more evolved creatures. These oscillations allow the anticipation of many physiological and behavioral mechanisms thus enabling coordination of rhythms in a timely manner, adaption to environmental changes and more efficient organization of the cellular processes responsible for survival of both the individual and the species. Many components of energy homeostasis exhibit circadian rhythms, which are regulated by central (suprachiasmatic nucleus) and peripheral (located in other tissues) circadian clocks. Adipocyte plays an important role in the regulation of energy homeostasis, the signaling of satiety and cellular differentiation and proliferation. Also, the adipocyte circadian clock is probably involved in the control of many of these functions. Thus, circadian clocks are implicated in the control of energy balance, feeding behavior and consequently in the regulation of body weight. In this regard, alterations in clock genes and rhythms can interfere with the complex mechanism of metabolic and hormonal anticipation, contributing to multifactorial diseases such as obesity and diabetes. The aim of this review was to define circadian clocks by describing their functioning and role in the whole body and in adipocyte metabolism, as well as their influence on body weight control and the development of obesity.  
  Address Laboratory of Cellular and Molecular Endocrinology (LIM/25) – University of Sao Paulo Medical School, Sao Paulo, Brazil. mzanquetta@usp.br  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1758-5996 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20712885; PMCID:PMC2930623 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 838  
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