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Author Sahar, S.; Sassone-Corsi, P. url  doi
openurl 
  Title Regulation of metabolism: the circadian clock dictates the time Type Journal Article
  Year 2012 Publication Trends in Endocrinology and Metabolism: TEM Abbreviated Journal Trends Endocrinol Metab  
  Volume 23 Issue 1 Pages 1-8  
  Keywords Animals; Chronobiology Disorders/metabolism; *Circadian Clocks; *Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins/metabolism; *Energy Metabolism; Humans; Metabolome  
  Abstract Circadian rhythms occur with a periodicity of approximately 24h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.  
  Address Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA 92697, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1043-2760 ISBN Medium  
  Area (up) Expedition Conference  
  Notes PMID:22169754; PMCID:PMC3259741 Approved no  
  Call Number IDA @ john @ Serial 151  
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Author Evans, J.A.; Elliott, J.A.; Gorman, M.R. url  doi
openurl 
  Title Dim nighttime illumination accelerates adjustment to timezone travel in an animal model Type Journal Article
  Year 2009 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume 19 Issue 4 Pages R156-7  
  Keywords *Adaptation, Physiological; Animals; Behavior, Animal/physiology; Biological Clocks/*physiology; Circadian Rhythm/*physiology; Cricetinae; Humans; *Lighting; Mesocricetus; Mice; Motor Activity/physiology; Phodopus; *Photoperiod; Time Factors  
  Abstract Jetlag reflects a mismatch between local and circadian time following rapid timezone travel [1]. Appropriately timed bright light can shift human circadian rhythms but recovery is slow (e.g., 1-2 days per timezone). Most symptoms subside after resynchronization, but chronic jetlag may have enduring negative effects [2], including even accelerated mortality in mice [3]. Melatonin, prescription drugs, and/or exercise may help shift the clock but, like bright light, require complex schedules of application [1]. Thus, there is a need for more efficient and practical treatments for addressing jetlag. In contrast to bright daytime lighting, nighttime conditions have received scant attention. By incorporating more naturalistic nighttime lighting comparable in intensity to dim moonlight, we demonstrate that recovery after simulated jetlag is accelerated when nights are dimly lit rather than completely dark.  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0960-9822 ISBN Medium  
  Area (up) Expedition Conference  
  Notes PMID:19243688 Approved no  
  Call Number IDA @ john @ Serial 152  
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Author Fritschi, L.; Erren, T.C.; Glass, D.C.; Girschik, J.; Thomson, A.K.; Saunders, C.; Boyle, T.; El-Zaemey, S.; Rogers, P.; Peters, S.; Slevin, T.; D'Orsogna, A.; de Vocht, F.; Vermeulen, R.; Heyworth, J.S. url  doi
openurl 
  Title The association between different night shiftwork factors and breast cancer: a case-control study Type Journal Article
  Year 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 109 Issue 9 Pages 2472-2480  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Female; Humans; Life Style; Middle Aged; Questionnaires; Risk; Risk Factors; Western Australia/epidemiology; *Work Schedule Tolerance; Young Adult; oncogenesis  
  Abstract BACKGROUND: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). METHODS: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. RESULTS: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR)=1.16, 95% confidence interval (CI)=0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR=1.22, 95% CI=1.01-1.47) with a statistically significant dose-response relationship (P=0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. CONCLUSION: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.  
  Address Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area (up) Expedition Conference  
  Notes PMID:24022188; PMCID:PMC3817316 Approved no  
  Call Number IDA @ john @ Serial 153  
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Author Knutsson, A.; Alfredsson, L.; Karlsson, B.; Akerstedt, T.; Fransson, E.I.; Westerholm, P.; Westerlund, H. url  doi
openurl 
  Title Breast cancer among shift workers: results of the WOLF longitudinal cohort study Type Journal Article
  Year 2013 Publication Scandinavian Journal of Work, Environment & Health Abbreviated Journal Scand J Work Environ Health  
  Volume 39 Issue 2 Pages 170-177  
  Keywords Adult; Aged; Breast Neoplasms/*epidemiology/etiology; Circadian Rhythm; Female; Humans; Incidence; Longitudinal Studies; Middle Aged; Proportional Hazards Models; Risk Assessment; Sweden/epidemiology; *Work Schedule Tolerance; oncogenesis  
  Abstract OBJECTIVE: The aim of this study was to investigate whether shift work (with or without night work) is associated with increased risk of breast cancer. METHODS: The population consisted of 4036 women. Data were obtained from WOLF (Work, Lipids, and Fibrinogen), a longitudinal cohort study. Information about baseline characteristics was based on questionnaire responses and medical examination. Cancer incidence from baseline to follow-up was obtained from the national cancer registry. Two exposure groups were identified: shift work with and without night work. The group with day work only was used as the reference group in the analysis. Cox regression analysis was used to calculate relative risk. RESULTS: In total, 94 women developed breast cancer during follow-up. The average follow-up time was 12.4 years. The hazard ratio for breast cancer was 1.23 [95% confidence interval (95% CI) 0.70-2.17] for shifts without night work and 2.02 (95% CI 1.03-3.95) for shifts with night work. When including only women <60 years of age, the risk estimates were 1.18 (95% CI 0.67-2.07) for shifts without night work, and 2.15 (95% CI 1.10-4.21) for shifts with night work. CONCLUSIONS: Our results indicate an increased risk for breast cancer among women who work shifts that includes night work.  
  Address Department of Health Sciences, Mid Sweden University, Sundsvall. Sweden. Anders.Knutsson@miun.se  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0355-3140 ISBN Medium  
  Area (up) Expedition Conference  
  Notes PMID:23007867 Approved no  
  Call Number IDA @ john @ Serial 154  
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Author Stevens, R.G.; Brainard, G.C.; Blask, D.E.; Lockley, S.W.; Motta, M.E. url  doi
openurl 
  Title Breast cancer and circadian disruption from electric lighting in the modern world Type Journal Article
  Year 2014 Publication CA: a Cancer Journal for Clinicians Abbreviated Journal CA Cancer J Clin  
  Volume 64 Issue 3 Pages 207-218  
  Keywords breast neoplasms; circadian clock; melatonin production; shift work; sleep duration; oncogenesis  
  Abstract Breast cancer is the leading cause of cancer death among women worldwide, and there is only a limited explanation of why. Risk is highest in the most industrialized countries but also is rising rapidly in the developing world. Known risk factors account for only a portion of the incidence in the high-risk populations, and there has been considerable speculation and many false leads on other possibly major determinants of risk, such as dietary fat. A hallmark of industrialization is the increasing use of electricity to light the night, both within the home and without. It has only recently become clear that this evolutionarily new and, thereby, unnatural exposure can disrupt human circadian rhythmicity, of which three salient features are melatonin production, sleep, and the circadian clock. A convergence of research in cells, rodents, and humans suggests that the health consequences of circadian disruption may be substantial. An innovative experimental model has shown that light at night markedly increases the growth of human breast cancer xenografts in rats. In humans, the theory that light exposure at night increases breast cancer risk leads to specific predictions that are being tested epidemiologically: evidence has accumulated on risk in shift workers, risk in blind women, and the impact of sleep duration on risk. If electric light at night does explain a portion of the breast cancer burden, then there are practical interventions that can be implemented, including more selective use of light and the adoption of recent advances in lighting technology and application. CA Cancer J Clin 2014;64:207-218. ((c)) 2013 American Cancer Society.  
  Address Professor, Department of Community Medicine, University of Connecticut Health Center, Farmington, CT  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-9235 ISBN Medium  
  Area (up) Expedition Conference  
  Notes PMID:24604162; PMCID:PMC4038658 Approved no  
  Call Number IDA @ john @ Serial 155  
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