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Author (down) Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A.
Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control
Volume 25 Issue 1 Pages 1073274818812908
Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED
Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.
Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1073-2748 ISBN Medium
Area Expedition Conference
Notes PMID:30477310; PMCID:PMC6259078 Approved no
Call Number IDA @ john @ Serial 2143
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Author (down) Zschokke, S.; Herberstein, M.E.
Title Laboratory Methods For Maintaining And Studying Web-Building Spiders Type Journal Article
Year 2005 Publication Journal of Arachnology Abbreviated Journal Journal of Arachnology
Volume 33 Issue 2 Pages 205-213
Keywords Animals; data collection; in various scien-; laboratory manual; methodology; popular model; spider silk; spider web; system to address questions; web-building spiders
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0161-8202 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kagoburian @ Serial 677
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Author (down) Zozaya, S.M.; Alford, R.A.; Schwarzkopf, L.
Title Invasive house geckos are more willing to use artificial lights than are native geckos: House geckos and artificial lights Type Journal Article
Year 2015 Publication Austral Ecology Abbreviated Journal Austral Ecology
Volume 40 Issue 8 Pages 982–987
Keywords Animals
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1442-9985 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ christopher.kyba @ Serial 1209
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Author (down) Zoogman, P.; Liu, X.; Suleiman, R.M.; Pennington, W.F.; Flittner, D.E.; Al-Saadi, J.A.; Hilton, B.B.; Nicks, D.K.; Newchurch, M.J.; Carr, J.L.; Janz, S.J.; Andraschko, M.R.; Arola, A.; Baker, B.D.; Canova, B.P.; Chan Miller, C.; Cohen, R.C.; Davis, J.E.; Dussault, M.E.; Edwards, D.P.; Fishman, J.; Ghulam, A.; González Abad, G.; Grutter, M.; Herman, J.R.; Houck, J.; Jacob, D.J.; Joiner, J.; Kerridge, B.J.; Kim, J.; Krotkov, N.A.; Lamsal, L.; Li, C.; Lindfors, A.; Martin, R.V.; McElroy, C.T.; McLinden, C.; Natraj, V.; Neil, D.O.; Nowlan, C.R.; OSullivan, E.J.; Palmer, P.I.; Pierce, R.B.; Pippin, M.R.; Saiz-Lopez, A.; Spurr, R.J.D.; Szykman, J.J.; Torres, O.; Veefkind, J.P.; Veihelmann, B.; Wang, H.; Wang, J.; Chance, K.
Title Tropospheric emissions: Monitoring of pollution (TEMPO) Type Journal Article
Year 2016 Publication Journal of Quantitative Spectroscopy and Radiative Transfer Abbreviated Journal Journal of Quantitative Spectroscopy and Radiative Transfer
Volume 186 Issue Pages 17-39
Keywords Instrumentation, Remote Sensing
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-4073 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1498
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Author (down) Zissell, R. E.
Title Shutter Mapping Correction for Short CCD Exposures. Type Journal Article
Year 2000 Publication Journal of the American Association of Variable Star Observers (JAAVSO) Abbreviated Journal
Volume 28 Issue Pages 149–156
Keywords Remote Sensing
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kagoburian @ Serial 983
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