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Author (down) Zubidat, A.E.; Haim, A. url  doi
openurl 
  Title Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity Type Journal Article
  Year 2017 Publication Journal of Basic and Clinical Physiology and Pharmacology Abbreviated Journal J Basic Clin Physiol Pharmacol  
  Volume 28 Issue 4 Pages 295-313  
  Keywords Human Health  
  Abstract Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important role in the development of these syndromes. However, we still poorly understand the molecular mechanism underlying the association between circadian disruption and the modern health syndromes. One promising candidate is epigenetic modifications of various genes, including clock genes, circadian-related genes, oncogenes, and metabolic genes. DNA methylation is the most prominent epigenetic signaling tool for gene expression regulation induced by environmental exposures, such as artificial light-at-night (ALAN). In this review, we first provide an overview on the molecular feedback loops that generate the circadian regulation and how circadian disruption by ALAN can impose adverse impacts on public health, particularly metabolic disorders and breast cancer development. We then focus on the relation between ALAN-induced circadian disruption and both global DNA methylation and specific loci methylation in relation to obesity and breast cancer morbidities. DNA hypo-methylation and DNA hyper-methylation, are suggested as the most studied epigenetic tools for the activation and silencing of genes that regulate metabolic and monostatic responses. Finally, we discuss the potential clinical and therapeutic roles of MLT suppression and DNA methylation patterns as novel biomarkers for the early detection of metabolic disorders and breast cancer development.  
  Address  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0792-6855 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28682785 Approved no  
  Call Number LoNNe @ kyba @ Serial 1680  
Permanent link to this record
 

 
Author (down) Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A. url  doi
openurl 
  Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
  Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control  
  Volume 25 Issue 1 Pages 1073274818812908  
  Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED  
  Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.  
  Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher SAGE Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1073-2748 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30477310; PMCID:PMC6259078 Approved no  
  Call Number IDA @ john @ Serial 2143  
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Author (down) Zschokke, S.; Herberstein, M.E. url  doi
openurl 
  Title Laboratory Methods For Maintaining And Studying Web-Building Spiders Type Journal Article
  Year 2005 Publication Journal of Arachnology Abbreviated Journal Journal of Arachnology  
  Volume 33 Issue 2 Pages 205-213  
  Keywords Animals; data collection; in various scien-; laboratory manual; methodology; popular model; spider silk; spider web; system to address questions; web-building spiders  
  Abstract  
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  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8202 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 677  
Permanent link to this record
 

 
Author (down) Zozaya, S.M.; Alford, R.A.; Schwarzkopf, L. url  doi
openurl 
  Title Invasive house geckos are more willing to use artificial lights than are native geckos: House geckos and artificial lights Type Journal Article
  Year 2015 Publication Austral Ecology Abbreviated Journal Austral Ecology  
  Volume 40 Issue 8 Pages 982–987  
  Keywords Animals  
  Abstract  
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  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1442-9985 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1209  
Permanent link to this record
 

 
Author (down) Zoogman, P.; Liu, X.; Suleiman, R.M.; Pennington, W.F.; Flittner, D.E.; Al-Saadi, J.A.; Hilton, B.B.; Nicks, D.K.; Newchurch, M.J.; Carr, J.L.; Janz, S.J.; Andraschko, M.R.; Arola, A.; Baker, B.D.; Canova, B.P.; Chan Miller, C.; Cohen, R.C.; Davis, J.E.; Dussault, M.E.; Edwards, D.P.; Fishman, J.; Ghulam, A.; González Abad, G.; Grutter, M.; Herman, J.R.; Houck, J.; Jacob, D.J.; Joiner, J.; Kerridge, B.J.; Kim, J.; Krotkov, N.A.; Lamsal, L.; Li, C.; Lindfors, A.; Martin, R.V.; McElroy, C.T.; McLinden, C.; Natraj, V.; Neil, D.O.; Nowlan, C.R.; OSullivan, E.J.; Palmer, P.I.; Pierce, R.B.; Pippin, M.R.; Saiz-Lopez, A.; Spurr, R.J.D.; Szykman, J.J.; Torres, O.; Veefkind, J.P.; Veihelmann, B.; Wang, H.; Wang, J.; Chance, K. url  doi
openurl 
  Title Tropospheric emissions: Monitoring of pollution (TEMPO) Type Journal Article
  Year 2016 Publication Journal of Quantitative Spectroscopy and Radiative Transfer Abbreviated Journal Journal of Quantitative Spectroscopy and Radiative Transfer  
  Volume 186 Issue Pages 17-39  
  Keywords Instrumentation, Remote Sensing  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-4073 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1498  
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