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Author (up) Agarwal, N.; Srivastava, S.; Malik, S.; Rani, S.; Kumar, V.
Title Altered light conditions during spring: Effects on timing of migration and reproduction in migratory redheaded bunting (Emberiza bruniceps) Type Journal Article
Year 2015 Publication Biological Rhythm Research Abbreviated Journal Biological Rhythm Research
Volume 46 Issue 5 Pages 647-657
Keywords Animals
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0929-1016 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ christopher.kyba @ Serial 1166
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Author (up) Agbaria, S.; Haim, A.; Fares, F.; Zubidat, A.E.
Title Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase Type Journal Article
Year 2019 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume Issue Pages 1-15
Keywords Human Health; Cosinor analysis; DNA methyltransferases; global DNA methylation; melatonin; splenomegaly; tissue-specific
Abstract Currently, one of the most disputed hypotheses regarding breast cancer (BC) development is exposure to short wavelength artificial light at night (ALAN) as multiple studies suggest a possible link between them. This link is suggested to be mediated by nocturnal melatonin suppression that plays an integral role in circadian regulations including cell division. The objective of the research was to evaluate effects of 1 x 30 min/midnight ALAN (134 micro Wcm(-2), 460 nm) with or without nocturnal melatonin supplement on tumor development and epigenetic responses in 4T1 tumor-bearing BALB/c mice. Mice were monitored for body mass (Wb) and tumor volume for 3 weeks and thereafter urine samples were collected at regular intervals for determining daily rhythms of 6-sulfatoxymelatonin (6-SMT). Finally, mice were sacrificed and the tumor, lungs, liver, and spleen were excised for analyzing the total activity of DNA methyltransferases (DNMT) and global DNA methylation (GDM) levels. Mice exposed to ALAN significantly reduced 6-SMT levels and increased Wb, tumor volume, and lung metastasis compared with controls. These effects were diminished by melatonin. The DNMT activity and GDM levels showed tissue-specific response. The enzymatic activity and GDM levels were lower in tumor and liver and higher in spleen and lungs under ALAN compared with controls. Our results suggest that ALAN disrupts the melatonin rhythm and potentially leading to increased BC burden by affecting DNMT activity and GDM levels. These data may also be applicable to early detection and management of BC by monitoring melatonin and GDM levels as early biomarker of ALAN circadian disruption.
Address b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa , Haifa , Israel; Zubidat3(at)013.net.il
Corporate Author Thesis
Publisher Taylor & Francis Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:30746962 Approved no
Call Number IDA @ john @ Serial 2211
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Author (up) Agbaria, S.; Haim, A.; Fares, F.; Zubidat, A.E.
Title Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase Type Journal Article
Year 2019 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume in press Issue Pages
Keywords Animals
Abstract Currently, one of the most disputed hypotheses regarding breast cancer (BC) development is exposure to short wavelength artificial light at night (ALAN) as multiple studies suggest a possible link between them. This link is suggested to be mediated by nocturnal melatonin suppression that plays an integral role in circadian regulations including cell division. The objective of the research was to evaluate effects of 1 x 30 min/midnight ALAN (134 micro Wcm(-2), 460 nm) with or without nocturnal melatonin supplement on tumor development and epigenetic responses in 4T1 tumor-bearing BALB/c mice. Mice were monitored for body mass (Wb) and tumor volume for 3 weeks and thereafter urine samples were collected at regular intervals for determining daily rhythms of 6-sulfatoxymelatonin (6-SMT). Finally, mice were sacrificed and the tumor, lungs, liver, and spleen were excised for analyzing the total activity of DNA methyltransferases (DNMT) and global DNA methylation (GDM) levels. Mice exposed to ALAN significantly reduced 6-SMT levels and increased Wb, tumor volume, and lung metastasis compared with controls. These effects were diminished by melatonin. The DNMT activity and GDM levels showed tissue-specific response. The enzymatic activity and GDM levels were lower in tumor and liver and higher in spleen and lungs under ALAN compared with controls. Our results suggest that ALAN disrupts the melatonin rhythm and potentially leading to increased BC burden by affecting DNMT activity and GDM levels. These data may also be applicable to early detection and management of BC by monitoring melatonin and GDM levels as early biomarker of ALAN circadian disruption.
Address b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa , Haifa , Israel
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:30746962 Approved no
Call Number GFZ @ kyba @ Serial 2212
Permanent link to this record
 

 
Author (up) Agnew, J.; Gillespie, T.W.; Gonzalez, J.; Min, B.
Title Baghdad Nights: Evaluating the US Military ‘Surge’ Using Nighttime Light Signatures Type Journal Article
Year 2008 Publication Environment and Planning A Abbreviated Journal Environ Plan A
Volume 40 Issue 10 Pages 2285-2295
Keywords Remote Sensing; Commentary
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0308-518X ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2028
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Author (up) Ahmed, AK; Sadik, MA
Title Study of sky brightness profiles of Baghdad and Karbala cities in Iraq Type Journal Article
Year 2018 Publication International Journal of Science and Nature Abbreviated Journal
Volume 9 Issue 1 Pages 18-24
Keywords Skyglow
Abstract This study was used two detectors only i.e., the human eye and photometer of Sky Quality Meter (SQM-LU) during the time of sunrise and sunset. The human eye used to determine the moon's phase. The measurements of sky brightness, by using SQM-LU, performed via two locations that covered Baghdad and Karbala in Iraq from December 2016 through March 2017 intermittently. The research focused only on light perceived by detectors and not how it happens. The aim of research is to find a mathematical formula (i.e . brightness contrast) between the sky brightness against the solar altitude by taking moon illumination as the standard reference. Analytical software based on the Python's PyEphem astrometry library was developed to calculate the solar altitude at the two locations. Finally, the formula of sky brightness obtained from this work is an important key that contributed to finding the simulated sky brightness, when the sun's altitude is known.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 1851
Permanent link to this record