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Author (up) Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L. url  doi
openurl 
  Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
  Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol  
  Volume in press Issue Pages  
  Keywords Vision  
  Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.  
  Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0340-5761 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30778631 Approved no  
  Call Number GFZ @ kyba @ Serial 2229  
Permanent link to this record
 

 
Author (up) Alamús, R.; Bará, S.; Corbera, J.; Escofet, J.; Palà , V.; Pipia, L.; Tardà, A. url  doi
openurl 
  Title Ground-based hyperspectral analysis of the urban nightscape Type Journal Article
  Year 2017 Publication ISPRS Journal of Photogrammetry and Remote Sensing Abbreviated Journal ISPRS Journal of Photogrammetry and Remote Sensing  
  Volume 124 Issue Pages 16-26  
  Keywords Instrumentation; Remote Sensing  
  Abstract Airborne hyperspectral cameras provide the basic information to estimate the energy wasted skywards by outdoor lighting systems, as well as to locate and identify their sources. However, a complete characterization of the urban light pollution levels also requires evaluating these effects from the city dwellers standpoint, e.g. the energy waste associated to the excessive illuminance on walls and pavements, light trespass, or the luminance distributions causing potential glare, to mention but a few. On the other hand, the spectral irradiance at the entrance of the human eye is the primary input to evaluate the possible health effects associated with the exposure to artificial light at night, according to the more recent models available in the literature. In this work we demonstrate the possibility of using a hyperspectral imager (routinely used in airborne campaigns) to measure the ground-level spectral radiance of the urban nightscape and to retrieve several magnitudes of interest for light pollution studies. We also present the preliminary results from a field campaign carried out in the downtown of Barcelona.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0924-2716 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1613  
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Author (up) Albers, S.; Duriscoe, D.M. url  openurl
  Title Modeling light pollution from population data and implications for National Park Service lands. Type Journal Article
  Year 2001 Publication George Wright Forum Abbreviated Journal  
  Volume 18 Issue Pages 56-68  
  Keywords Skyglow  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 555  
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Author (up) Alberts, E., openurl 
  Title Straßenbeleuchtung im Gespräch. Historisch, nostalgisch oder zweckmäßig Type Journal Article
  Year 1985 Publication LICHT Abbreviated Journal  
  Volume 37 Issue 4 Pages 266–271  
  Keywords History  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 984  
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Author (up) Albreiki, Mohammed S. url  openurl
  Title The effects of light at night and/or melatonin on hormones, metabo- lites, appetite control, vascular function, and behavioural responses. Type Journal Article
  Year 2017 Publication University of Surrey Abbreviated Journal  
  Volume Issue Pages  
  Keywords Human Health  
  Abstract Light at night (LAN) is a major factor in disruption of SCN function, including melatonin suppression. Melatonin has been linked to a variety of biological processes such as lipid and glucose metabolism, vascular parameters, appetite, and behaviour. However, few human studies have investigated the effect of LAN and suppressed melatonin prior to and after an evening meal. The current thesis aims to investigate the impact of light at night and/or mela- tonin on hormones, metabolites, appetite, vascular function, and behaviour prior to and after an evening test meal in healthy participants. The first study investigated the effect of dim or bright light conditions on hor- mones, metabolites, appetite, vascular function and behavioural responses. Glucose tolerance and insulin sensitivity were reduced, lipid profiles altered and salivary melatonin suppressed under bright light compared to dim light conditions. Subjec- tive mood was improved and appetite scores increased in bright light. No differences were seen in vascular parameters. Although clear differences were apparent it could not be determined whether the effects were due to the light at night, the absence of melatonin or a combination of the two. The second study involved three conditions with the administration of exogenous melatonin 90 mins before the evening test meal under bright and dim light conditions compared to bright light alone with the consequent melatonin suppression. Glucose tolerance and insulin sensitivity were reduced and lipid profile altered in bright light when melatonin was suppressed compared to the two conditions with exogenous melatonin. Mood was improved and appetite increased with lower leptin levels and elevated wrist temperature with bright light and suppressed melatonin. Statistical analysis showed that the major effects were due to melatonin. These studies demonstrate a possible role for melatonin in glucose tolerance, insulin sensitivity and lipid metabolism when eating late at night which may have implications for shift-workers.  
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  Corporate Author Thesis Ph.D. thesis  
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  Notes Approved no  
  Call Number LoNNe @ kyba @; GFZ @ kyba @ Serial 1747  
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