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Author Buonfiglio, D.; Parthimos, R.; Dantas, R.; Cerqueira Silva, R.; Gomes, G.; Andrade-Silva, J.; Ramos-Lobo, A.; Amaral, F.G.; Matos, R.; Sinesio, J.J.; Motta-Teixeira, L.C.; Donato, J.J.; Reiter, R.J.; Cipolla-Neto, J. url  doi
openurl 
  Title Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats Type Journal Article
  Year 2018 Publication Frontiers in Endocrinology Abbreviated Journal Front Endocrinol (Lausanne)  
  Volume 9 Issue Pages 122  
  Keywords Human health  
  Abstract Melatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclear; herein we investigated how Mel regulates energy intake and expenditure to promote a proper energy balance. Male Wistar rats were assigned to control, control + Mel, pinealectomized (PINX) and PINX + Mel groups. To restore a 24-h rhythm, Mel (1 mg/kg) was added to the drinking water exclusively during the dark phase for 13 weeks. After this treatment period, rats were subjected to a 24-h fasting test, an acute leptin responsiveness test and cold challenge. Mel treatment reduced food intake, body weight, and adiposity. When challenged to 24-h fasting, Mel-treated rats also showed reduced hyperphagia when the food was replaced. Remarkably, PINX rats exhibited leptin resistance; this was likely related to the capacity of leptin to affect body weight, food intake, and hypothalamic signal-transducer and activator of transcription 3 phosphorylation, all of which were reduced. Mel treatment restored leptin sensitivity in PINX rats. An increased hypothalamic expression of agouti-related peptide (Agrp), neuropeptide Y, and Orexin was observed in the PINX group while Mel treatment reduced the expression of Agrp and Orexin. In addition, PINX rats presented lower UCP1 protein levels in the brown adipose tissue and required higher tail vasoconstriction to get a proper thermogenic response to cold challenge. Our findings reveal a previously unrecognized interaction of Mel and leptin in the hypothalamus to regulate the energy balance. These findings may help to explain the high incidence of metabolic diseases in individuals exposed to light at night.  
  Address Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of Sao Paulo (USP), Sao Paulo, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1664-2392 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29636725; PMCID:PMC5881424 Approved no  
  Call Number (down) NC @ ehyde3 @ Serial 2093  
Permanent link to this record
 

 
Author Zhou, Y.; Zhang, H.-K.; Liu, F.; Lei, G.; Liu, P.; Jiao, T.; Dang, Y.-H. url  doi
openurl 
  Title Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice Type Journal Article
  Year 2018 Publication Frontiers in Behavioral Neuroscience Abbreviated Journal Front Behav Neurosci  
  Volume 12 Issue Pages 110  
  Keywords Animals  
  Abstract In recent years, the environmental impact of artificial light at night has been a rapidly growing global problem, affecting 99% of the population in the US and Europe, and 62% of the world population. The present study utilized a mouse model exposed to long-term artificial light and light deprivation to explore the impact of these conditions on emotion and cognition. Based on the potential links between histidine triad nucleotide binding protein 1 (HINT1) and mood disorders, we also examined the expression of HINT1 and related apoptosis factors in the suprachiasmatic nucleus (SCN), prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus (Hip). Mice exposed to constant light (CL) exhibited depressive- and anxiety-like behaviors, as well as impaired spatial memory, as demonstrated by an increased immobility time in the tail suspension and forced swimming tests, less entries and time spent in the open arms of elevated plus-maze, and less platform site crossings and time spent in the target quadrant in the Morris water maze (MWM). The effects of constant darkness (CD) partially coincided with long-term illumination, except that mice in the CD group failed to show anxiety-like behaviors. Furthermore, HINT1 was upregulated in four encephalic regions, indicating that HINT1 may be involved in mood disorders and cognitive impairments due to altered light exposure. The apoptosis-related proteins, BAX and BCL-2, showed the opposite expression pattern, reflecting an activated apoptotic pathway. These findings suggest that exposure to CL and/or darkness can induce significant changes in affective and cognitive responses, possibly through HINT1-induced activation of apoptotic pathways.  
  Address College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1662-5153 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29937721; PMCID:PMC6002487 Approved no  
  Call Number (down) NC @ ehyde3 @ Serial 2094  
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Author Pan, J.; Hu, Y. url  doi
openurl 
  Title Spatial Identification of Multi-dimensional Poverty in Rural China: A Perspective of Nighttime-Light Remote Sensing Data Type Journal Article
  Year 2018 Publication Journal of the Indian Society of Remote Sensing Abbreviated Journal J Indian Soc Remote Sens  
  Volume 46 Issue 7 Pages 1093-1111  
  Keywords Remote sensing  
  Abstract Poverty has emerged as one of the chronic dilemmas facing the development of human society during the twenty first century. Accurately identifying regions of poverty could lead to more effective poverty-alleviation programs. This study used a new type of remote-sensing data, NPP-VIIRS, to locate poverty-stricken areas based on nighttime light, taking Chongqing Municipality as a sample, and constructed a multidimensional poverty index (MPI) system, guided by a well-known and widely used conceptual framework of sustainable livelihood. A regression model was constructed and results were correlated with those using the average nighttime light index. The model was then tested on Shaanxi Province, and average relative error of the estimated MPI was only 11.12%. These results showed that multidimensional poverty had a high spatial concentration effect at the regional scale. We then applied the index nationwide, at the county scale, analyzing 2852 counties, which we divided into seven classifications, based on the MPI: extremely low, low, relatively low, medium, relatively high, high, and extremely high. Eight hundred forty-eight counties in 26 provinces were identified as multidimensionally poor. Among these, 254 were absolutely poor counties and 543 were relatively poor counties; 195 of these are not on the list of poverty-stricken counties as identified by income levels alone. By improving the accuracy of targeting, this method of identifying multidimensional poverty areas could help the Chinese government improve the effectiveness of poverty reduction strategies, and it could also be used as a reference for other countries or regions that seek to target poor areas that suffer multidimensional deprivation.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0255-660X ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (down) NC @ ehyde3 @ Serial 2095  
Permanent link to this record
 

 
Author Kazemidemneh, M.; Mahdavinejad, M. url  doi
openurl 
  Title Use of Space Syntax Technique to Improve the Quality of Lighting and Modify Energy Consumption Patterns in Urban Spaces Type Journal Article
  Year 2018 Publication European Journal of Sustainable Development Abbreviated Journal  
  Volume 7 Issue 2 Pages 29-40  
  Keywords Lighting  
  Abstract Urban lighting is one of the significant issues that urban designers and architects are facing, and it has received a special attention in recent years. Urban lighting pursues critical goals such as preserving the livability of the city during nighttime, providing a sense of security, maintaining the city‟s readability, etc. Use of incompatible patterns for lighting design wastes significant amount of energy annually. A master lighting plan for urban areas should be recommended to achieve these goals and prevent wasteful energy use in lighting. One of the solutions for designing an appropriate plan is to notice the pedestrian traffic pattern in the city by considering space syntax model and integration maps analysis. In this research, one of Tehran‟s regions has been chosen and its integration map has been generated using appropriate software. Tehran is selected as case study of this research while the results might be applied in other similar cities especially in developing countries. First, based on the integration degree of the passages which reveals pedestrian traffic pattern and considering recommended illuminance standards, the average required lighting has been determined. Second, comparing the measured lighting intensity and the standard amounts reveals the correlation between the presented urban lighting and energy consumption model. Eventually, different solutions for appropriate urban lighting design based on acceptable energy consumption patterns have been suggested.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (down) NC @ ehyde3 @ Serial 2096  
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Author Landis, E.G.; Yang, V.; Brown, D.M.; Pardue, M.T.; Read, S.A. url  doi
openurl 
  Title Dim Light Exposure and Myopia in Children Type Journal Article
  Year 2018 Publication Investigative Ophthalmology & Visual Science Abbreviated Journal Invest Ophthalmol Vis Sci  
  Volume 59 Issue 12 Pages 4804-4811  
  Keywords Human Health  
  Abstract Purpose: Experimental myopia in animal models suggests that bright light can influence refractive error and prevent myopia. Additionally, animal research indicates activation of rod pathways and circadian rhythms may influence eye growth. In children, objective measures of personal light exposure, recorded by wearable light sensors, have been used to examine the effects of bright light exposure on myopia. The effect of time spent in a broad range of light intensities on childhood refractive development is not known. This study aims to evaluate dim light exposure in myopia. Methods: We reanalyzed previously published data to investigate differences in dim light exposure across myopic and nonmyopic children from the Role of Outdoor Activity in Myopia (ROAM) study in Queensland, Australia. The amount of time children spent in scotopic (<1-1 lux), mesopic (1-30 lux), indoor photopic (>30-1000 lux), and outdoor photopic (>1000 lux) light over both weekdays and weekends was measured with wearable light sensors. Results: We found significant differences in average daily light exposure between myopic and nonmyopic children. On weekends, myopic children received significantly less scotopic light (P = 0.024) and less outdoor photopic light than nonmyopic children (P < 0.001). In myopic children, more myopic refractive errors were correlated with increased time in mesopic light (R = -0.46, P = 0.002). Conclusions: These findings suggest that in addition to bright light exposure, rod pathways stimulated by dim light exposure could be important to human myopia development. Optimal strategies for preventing myopia with environmental light may include both dim and bright light exposure.  
  Address School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0146-0404 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30347074; PMCID:PMC6181186 Approved no  
  Call Number (down) NC @ ehyde3 @ Serial 2097  
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