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Author Kessel, L.; Siganos, G.; Jorgensen, T.; Larsen, M. url  doi
openurl 
  Title Sleep disturbances are related to decreased transmission of blue light to the retina caused by lens yellowing Type Journal Article
  Year 2011 Publication Sleep Abbreviated Journal Sleep  
  Volume 34 Issue 9 Pages 1215-1219  
  Keywords (up) Adult; Age Factors; Aging/*pathology/physiology; Circadian Rhythm/physiology; Cross-Sectional Studies; Female; Fluorometry; Humans; Lens, Crystalline/*pathology/physiopathology; *Light; Male; Middle Aged; Retina/*physiopathology; Risk Factors; *Scattering, Radiation; Sleep Disorders/*etiology; Circadian rhythm; cataract; melanopsin; sleep; blue light  
  Abstract STUDY OBJECTIVES: Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the human lens, and this may impair the photoentrainment of circadian rhythm leading to sleep disorders. The aim of the study was to examine the association between lens aging and sleep disorders. DESIGN: Cross-sectional population based study. SETTING: The study was performed at the Research Center for Prevention and Health, Glostrup Hospital, Denmark and at the Department of Ophthalmology, Herlev Hospital, Denmark. PARTICIPANTS: An age- and sex-stratified sample of 970 persons aged 30 to 60 years of age drawn from a sample randomly selected from the background population. INTERVENTIONS: Not applicable. MEASUREMENTS AND RESULTS: Sleep disturbances were evaluated by a combination of questionnaire and the use of prescription sleeping medication. Lens aging (transmission and yellowing) was measured objectively by lens autofluorometry. The risk of sleep disturbances was significantly increased when the transmission of blue light to the retina was low, even after correction for the effect of age and other confounding factors such as smoking habits, diabetes mellitus, gender, and the risk of ischemic heart disease (P < 0.0001). CONCLUSIONS: Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms.  
  Address Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark. line.kessel@dadlnet.dk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21886359; PMCID:PMC3157663 Approved no  
  Call Number IDA @ john @ Serial 344  
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Author Parent, M.-E.; El-Zein, M.; Rousseau, M.-C.; Pintos, J.; Siemiatycki, J. url  doi
openurl 
  Title Night work and the risk of cancer among men Type Journal Article
  Year 2012 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 176 Issue 9 Pages 751-759  
  Keywords (up) Adult; Aged; *Circadian Rhythm; Humans; Male; *Men's Health; Middle Aged; Neoplasms/*epidemiology; Occupations/*statistics & numerical data; Personnel Staffing and Scheduling/*statistics & numerical data; Quebec/epidemiology; Risk Factors; oncogenesis  
  Abstract Night work might influence cancer risk, possibly via suppression of melatonin release. In a population-based case-control study conducted in Montreal, Quebec, Canada, between 1979 and 1985, job histories, including work hours, were elicited from 3,137 males with incident cancer at one of 11 anatomic sites and from 512 controls. Compared with men who never worked at night, the adjusted odds ratios among men who ever worked at night were 1.76 (95% confidence interval (CI): 1.25, 2.47) for lung cancer, 2.03 (95% CI: 1.43, 2.89) for colon cancer, 1.74 (95% CI: 1.22, 2.49) for bladder cancer, 2.77 (95% CI: 1.96, 3.92) for prostate cancer, 2.09 (95% CI: 1.40, 3.14) for rectal cancer, 2.27 (95% CI: 1.24, 4.15) for pancreatic cancer, and 2.31 (95% CI: 1.48, 3.61) for non-Hodgkin's lymphoma. Equivocal evidence or no evidence was observed for cancers of the stomach (odds ratio (OR) = 1.34, 95% CI: 0.85, 2.10), kidney (OR = 1.42, 95% CI: 0.86, 2.35), and esophagus (OR = 1.51, 95% CI: 0.80, 2.84) and for melanoma (OR = 1.04, 95% CI: 0.49, 2.22). There was no evidence of increasing risk with increasing duration of night work, with risks generally being increased across all duration categories. Results suggest that night work may increase cancer risk at several sites among men.  
  Address INRS-Institut Armand-Frappier, University of Quebec, Laval, Canada. marie-elise.parent@iaf.inrs.ca  
  Corporate Author Thesis  
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  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23035019 Approved no  
  Call Number IDA @ john @ Serial 158  
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Author Fritschi, L.; Erren, T.C.; Glass, D.C.; Girschik, J.; Thomson, A.K.; Saunders, C.; Boyle, T.; El-Zaemey, S.; Rogers, P.; Peters, S.; Slevin, T.; D'Orsogna, A.; de Vocht, F.; Vermeulen, R.; Heyworth, J.S. url  doi
openurl 
  Title The association between different night shiftwork factors and breast cancer: a case-control study Type Journal Article
  Year 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 109 Issue 9 Pages 2472-2480  
  Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Female; Humans; Life Style; Middle Aged; Questionnaires; Risk; Risk Factors; Western Australia/epidemiology; *Work Schedule Tolerance; Young Adult; oncogenesis  
  Abstract BACKGROUND: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). METHODS: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. RESULTS: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR)=1.16, 95% confidence interval (CI)=0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR=1.22, 95% CI=1.01-1.47) with a statistically significant dose-response relationship (P=0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. CONCLUSION: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.  
  Address Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia  
  Corporate Author Thesis  
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  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24022188; PMCID:PMC3817316 Approved no  
  Call Number IDA @ john @ Serial 153  
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Author Hansen, J.; Lassen, C.F. url  doi
openurl 
  Title Nested case-control study of night shift work and breast cancer risk among women in the Danish military Type Journal Article
  Year 2012 Publication Occupational and Environmental Medicine Abbreviated Journal Occup Environ Med  
  Volume 69 Issue 8 Pages 551-556  
  Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/*etiology; Case-Control Studies; *Circadian Rhythm; Denmark/epidemiology; Female; Humans; Logistic Models; Middle Aged; Military Personnel; *Occupations; Odds Ratio; Risk Factors; *Sunlight; *Work; *Work Schedule Tolerance; oncogenesis  
  Abstract OBJECTIVES: Growing but limited evidence suggests that night shift work is associated with breast cancer. The authors conducted a nationwide case-control study nested within a cohort of 18,551 female military employees born in 1929-1968 to investigate the risk for breast cancer after night shift work and to explore the role of leisure time sun exposure and diurnal preference. METHODS: The authors documented 218 cases of breast cancer (1990-2003) and selected 899 age-matched controls from the cohort by incidence density sampling. Information on shift work, sun exposure habits, diurnal preference and other potential confounders was obtained from a structured questionnaire. ORs were estimated by multivariate conditional logistic regression. RESULTS: Overall, the authors observed an adjusted OR of 1.4 (95% CI 0.9 to 2.1) among women with ever compared with never night shifts. The RR for breast cancer tended to increase with increasing number of years of night shift work (p=0.03) and with cumulative number of shifts (p=0.02),with a neutral risk for fewer than three night shifts per week. The OR for the group with the highest tertile of cumulative exposure was 2.3 (95% CI 1.2 to 4.6). The most pronounced effect of night shift work on breast cancer risk was observed in women with morning chronotype preference and intense night shifts (OR=3.9, 95% CI 1.6 to 9.5). Night shift workers tended to sunbathe more frequently than day workers. CONCLUSIONS: The results indicate that frequent night shift work increases the risk for breast cancer and suggest a higher risk with longer duration of intense night shifts. Women with morning preference who worked on night shifts tended to have a higher risk than those with evening preference.  
  Address Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK2100, Denmark. johnni@cancer.dk  
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  Series Volume Series Issue Edition  
  ISSN 1351-0711 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22645325 Approved no  
  Call Number IDA @ john @ Serial 156  
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Author Li, Q.; Zheng, T.; Holford, T.R.; Boyle, P.; Zhang, Y.; Dai, M. url  doi
openurl 
  Title Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA Type Journal Article
  Year 2010 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 21 Issue 12 Pages 2281-2285  
  Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology; Carcinoma/epidemiology/*etiology; Case-Control Studies; Circadian Rhythm/physiology; Connecticut/epidemiology; Female; Humans; *Light/adverse effects; Middle Aged; Population; Questionnaires; Risk Factors; United States/epidemiology; Work Schedule Tolerance/physiology; Oncogenesis  
  Abstract OBJECTIVE: To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer. METHODS: A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression. RESULTS: A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9). CONCLUSION: The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results.  
  Address Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20927578; PMCID:PMC3154700 Approved no  
  Call Number IDA @ john @ Serial 161  
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