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Author Papagiannakopoulos, T.; Bauer, M.R.; Davidson, S.M.; Heimann, M.; Subbaraj, L.; Bhutkar, A.; Bartlebaugh, J.; Vander Heiden, M.G.; Jacks, T.
Title Circadian Rhythm Disruption Promotes Lung Tumorigenesis Type Journal Article
Year 2016 Publication Cell Metabolism Abbreviated Journal Cell Metab
Volume 24 Issue 2 Pages 324–331
Keywords (up) Animals
Abstract Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Using a genetically engineered mouse model of lung adenocarcinoma, we have characterized the effects of circadian rhythm disruption on lung tumorigenesis. We demonstrate that both physiologic perturbation (jet lag) and genetic mutation of the central circadian clock components decreased survival and promoted lung tumor growth and progression. The core circadian genes Per2 and Bmal1 were shown to have cell-autonomous tumor-suppressive roles in transformation and lung tumor progression. Loss of the central clock components led to increased c-Myc expression, enhanced proliferation, and metabolic dysregulation. Our findings demonstrate that both systemic and somatic disruption of circadian rhythms contribute to cancer progression.
Address David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: tjacks@mit.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1550-4131 ISBN Medium
Area Expedition Conference
Notes PMID:27476975 Approved no
Call Number LoNNe @ kyba @ Serial 1497
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Author Plummer, K.E.; Hale, J.D.; O'Callaghan, M.J.; Sadler, J.P.; Siriwardena, G.M.
Title Investigating the impact of street lighting changes on garden moth communities Type Journal Article
Year 2016 Publication Journal of Urban Ecology Abbreviated Journal J Urban Ecol
Volume 2 Issue 1 Pages juw004
Keywords (up) Animals
Abstract Night time illumination of cities is undergoing radical change through the adoption of new street lighting technologies, but the impacts of these large-scale changes on biodiversity have not been explored. Moths are of particular concern because of their nocturnal ‘flight-to-light’ responses. Here we examine in situ effects of (1) street lamp replacement and (2) the spatial distribution of local street lighting on garden moth communities in Birmingham, UK, to determine whether current shifts in street lighting infrastructure are leading to an increased attraction of moths into suburban areas. Using a unique before-after-control-impact survey, we show that switching from narrow (low-pressure sodium) to broad spectrum (high-pressure sodium) lamps significantly increases the diversity of macro-moths in suburban gardens. Furthermore, we demonstrate the complex ways in which the moth community differentially responds to variation in street lighting characteristics. In particular we found that macro-moth attraction was greatest at high lamp densities, whilst micro-moth families responded more strongly to street lamp proximity and the density of UV-emitting lamps specifically. Our findings indicate that moths are attracted to suburban gardens with closer, more dense and more spectrally diverse local street lighting, and suggest that suburban areas could represent ecological traps for moth communities if they have insufficient resources to support moth survival and reproduction. Further research is now needed to determine whether street lighting is progressively damaging moth communities, and to understand whether these impacts could be mitigated through changes to street lighting regimes or through the provision of ecologically important habitats in urban landscapes.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2058-5543 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1500
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Author Farkas, A.; Szaz, D.; Egri, A.; Barta, A.; Meszaros, A.; Hegedus, R.; Horvath, G.; Kriska, G.
Title Mayflies are least attracted to vertical polarization: A polarotactic reaction helping to avoid unsuitable habitats Type Journal Article
Year 2016 Publication Physiology & Behavior Abbreviated Journal Physiol Behav
Volume 163 Issue Pages 219-227
Keywords (up) Animals
Abstract Like other aquatic insects, mayflies are positively polarotactic and locate water surfaces by means of the horizontal polarization of water-reflected light. However, may vertically polarized light also have implications for the swarming behaviour of mayflies? To answer this question, we studied in four field experiments the behavioural responses of Ephoron virgo and Caenis robusta mayflies to lamps emitting horizontally and vertically polarized and unpolarized light. In both species, unpolarized light induces positive phototaxis, horizontally polarized light elicits positive photo- and polarotaxis, horizontally polarized light is much more attractive than unpolarized light, and vertically polarized light is the least attractive if the stimulus intensities and spectra are the same. Vertically polarized light was the most attractive for C. robusta if its intensity was about two and five times higher than that of the unpolarized and horizontally polarized stimuli, respectively. We suggest that the mayfly behaviour observed in our experiments may facilitate the stability of swarming above water surfaces. Beside the open water surface reflecting horizontally polarized light, the shadow and mirror image of riparian vegetation at the edge of the water surface reflect weakly and non-horizontally (mainly vertically) polarized light. Due to their positive polarotaxis, flying mayflies remain continuously above the water surface, because they keep away from the unpolarized or non-horizontally polarizing edge regions (water surface and coast line) of water bodies. We also discuss how our findings can explain the regulation of mayfly colonization.
Address Danube Research Institute, MTA Centre for Ecological Research, H-1113 Budapest, Karolina ut 29-31, Hungary; Group for Methodology in Biology Teaching, Biological Institute, Eotvos University, H-1117 Budapest, Pazmany setany 1, Hungary. Electronic address: kriska@ludens.elte.hu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9384 ISBN Medium
Area Expedition Conference
Notes PMID:27178399 Approved no
Call Number LoNNe @ kyba @ Serial 1501
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Author Yang, Y.; Yu, Y.; Pan, J.; Ying, Y.; Zhou, H.
Title A new method to manipulate broiler chicken growth and metabolism: Response to mixed LED light system Type Journal Article
Year 2016 Publication Scientific Reports Abbreviated Journal Sci Rep
Volume 6 Issue Pages 25972
Keywords (up) Animals
Abstract Present study introduced a new method to manipulate broiler chicken growth and metabolism by mixing the growth-advantage LED. We found that the green/blue LED mixed light system (G-B and G x B) have the similar stimulatory effect on chick body weight with single green light and single blue light (G and B), compared with normal artificial light (P = 0.028). Moreover, the percentage of carcass was significantly greater in the mixed light (G x B) when compared with the single light (P = 0.003). Synchronized with body weight, the mixed light (G-B and G x B) had a significant improved influence on the feed conversion of birds compared with normal light (P = 0.002). A significant improvement in feed conversion were found in mixed light (G x B) compared with single LED light (P = 0.037). G group resulted in a greater high-density lipoprotein cholesterol level than B group (P = 0.002), whereas B group resulted in a greater low-density lipoprotein cholesterol level than G group (P = 0.017). The mixed light significantly increased the birds' glucose level in comparison with the single light (P = 0.003). This study might establish an effective strategy for maximizing growth of chickens by mixed LED technology.
Address Department of Instrument Science and Engineering, Zhejiang University, Hangzhou 310058, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2045-2322 ISBN Medium
Area Expedition Conference
Notes PMID:27170597; PMCID:PMC4864324 Approved no
Call Number LoNNe @ kyba @ Serial 1502
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Author Voiculescu, S.E.; Duc, D.L.; Rosca, A.E.; Zeca, V.; Chitimus, D.M.; Arsene, A.L.; Dragoi, C.M.; Nicolae, A.C.; Zagrean, L.; Schöneberg, T.; Zagrean, A.-M.
Title Behavioral and molecular effects of prenatal continuous light exposure in the adult rat Type Journal Article
Year 2016 Publication Brain Research Abbreviated Journal Brain Research
Volume 1650 Issue Pages 51–59
Keywords (up) Animals
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0006-8993 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1509
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