| Home | [11–20] << 21 22 23 24 25 26 27 28 29 30 >> [31–40] |
|
| Records | |||||
|---|---|---|---|---|---|
| Author | Reiter, R.; Tan, D.; SanchezBarcelo, E.; Mediavilla, M.; Gitto, E.; Korkmaz, A. | ||||
| Title | Circadian mechanisms in the regulation of melatonin synthesis: disruption with light at night and the pathophysiological consequences | Type | Journal Article | ||
| Year | 2011 | Publication | Journal of Experimental and Integrative Medicine | Abbreviated Journal | J Exp Integr Med |
| Volume | 1 | Issue | 1 | Pages | 13 |
| Keywords | Human Health | ||||
| Abstract | In the past two decades, the results of a number of epidemiological studies have uncovered an association between excessive light exposure at night and the prevalence of cancer. Whereas the evidence supporting this link is strongest between nighttime light and female breast and male prostate cancer, the frequency of other tumor types may also be elevated. Individuals who have the highest reported increase in cancer are chronic night shift workers and flight attendants who routinely fly across numerous time zones. There are at least two obvious physiological consequences of nighttime light exposure, i.e., a reduction in circulating melatonin levels and disruption of the circadian system (chronodisruption). Both these perturbations in experimental animals aggravate tumor growth. Melatonin has a long investigative history in terms of its ability to stymie the growth of many tumor types. Likewise, in the last decade chronodisruption has been unequivocally linked to a variety of abnormal metabolic conditions including excessive tumor growth. This brief review summarizes the processes by which light after darkness onset impedes melatonin production and disturbs circadian rhythms. The survey also reviews the evidence associating the ostensible danger of excessive nighttime light pollution to cancer risk. If an elevated tumor frequency is definitively proven to be a consequence of light at night and/or chronodisruption, it seems likely that cancer will not be the exclusive pathophysiological change associated with the rampant light pollution characteristic of modern societies. |
||||
| Address | |||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | Summary Language | Original Title | |||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 1309-4572 | ISBN | Medium  |
||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | IDA @ john @ | Serial | 137 | ||
| Permanent link to this record | |||||
| Author | Lin, J.B.; Gerratt, B.W.; Bassi, C.J.; Apte, R.S. | ||||
| Title | Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms of Eye Fatigue | Type | Journal Article | ||
| Year | 2017 | Publication | Investigative Ophthalmology & Visual Science | Abbreviated Journal | Invest Ophthalmol Vis Sci |
| Volume | 58 | Issue | 1 | Pages | 442-447 |
| Keywords | Human Health | ||||
| Abstract | Purpose: The purpose of this study was to determine whether subjects who wear short wavelength-blocking eyeglasses during computer tasks exhibit less visual fatigue and report fewer symptoms of visual discomfort than subjects wearing eyeglasses with clear lenses. Methods: A total of 36 healthy subjects (20 male; 16 female) was randomized to wearing no-block, low-blocking, or high-blocking eyeglasses while performing a 2-hour computer task. A masked grader measured critical flicker fusion frequency (CFF) as a metric of eye fatigue and evaluated symptoms of eye strain with a 15-item questionnaire before and after computer use. Results: We found that the change in CFF after the computer task was significantly more positive (i.e., less eye fatigue) in the high-block versus the no-block (P = 0.027) and low-block (P = 0.008) groups. Moreover, random assignment to the high-block group but not to the low-block group predicted a more positive change in CFF (i.e., less eye fatigue) following the computer task (adjusted beta = 2.310; P = 0.002). Additionally, subjects wearing high-blocking eyeglasses reported significantly less feeling pain around/inside the eye (P = 0.0063), less feeling that the eyes were heavy (P = 0.0189), and less feeling that the eyes were itchy (P = 0.0043) following the computer task, when compared to subjects not wearing high-blocking lenses. Conclusions: Our results support the hypothesis that short-wavelength light-blocking eyeglasses may reduce eye strain associated with computer use based on a physiologic correlate of eye fatigue and on subjects' reporting of symptoms typically associated with eye strain. | ||||
| Address | Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States 4Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States 5Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States | ||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0146-0404 | ISBN | Medium |
||
| Area | Expedition | Conference | |||
| Notes | PMID:28118668 | Approved | no | ||
| Call Number | LoNNe @ kyba @ | Serial | 1629 | ||
| Permanent link to this record | |||||
| Author | Dumont, M.; Lanctot, V.; Cadieux-Viau, R.; Paquet, J. | ||||
| Title | Melatonin production and light exposure of rotating night workers | Type | Journal Article | ||
| Year | 2012 | Publication | Chronobiology International | Abbreviated Journal | Chronobiol Int |
| Volume | 29 | Issue | 2 | Pages | 203-210 |
| Keywords | Adult; Animals; Circadian Rhythm/*physiology; Humans; *Light; Melatonin/*analogs & derivatives/*biosynthesis/urine; Neoplasms/etiology; *Photoperiod; Risk Factors; Sleep/physiology; *Work; Work Schedule Tolerance | ||||
| Abstract | Decreased melatonin production, due to acute suppression of pineal melatonin secretion by light exposure during night work, has been suggested to underlie higher cancer risks associated with prolonged experience of night work. However, the association between light exposure and melatonin production has never been measured in the field. In this study, 24-h melatonin production and ambulatory light exposure were assessed during both night-shift and day/evening-shift periods in 13 full-time rotating shiftworkers. Melatonin production was estimated with the excretion of urinary 6-sulfatoxymelatonin (aMT6s), and light exposure was measured with an ambulatory photometer. There was no difference in total 24-h aMT6s excretion between the two work periods. The night-shift period was characterized by a desynchrony between melatonin and sleep-wake rhythms, as shown by higher melatonin production during work and lower melatonin production during sleep when working night shifts than when working day/evening shifts. Light exposure during night work showed no correlation with aMT6s excreted during the night of work (p > .5), or with the difference in 24-h aMT6s excretion between the two work periods (p > .1). However, light exposure during night work was negatively correlated with total 24-h aMT6s excretion over the entire night-shift period (p < .01). In conclusion, there was no evidence of direct melatonin suppression during night work in this population. However, higher levels of light exposure during night work may have decreased total melatonin production, possibly by initiating re-entrainment and causing internal desynchrony. This interpretation is consistent with the proposition that circadian disruption, of which decreased melatonin production is only one of the adverse consequences, could be the mediator between night shiftwork and cancer risks. | ||||
| Address | Chronobiology Laboratory, Center for Advanced Research in Sleep Medicine, Sacre-Coeur Hospital of Montreal, Montreal, Quebec, Canada. marie.dumont@umontreal.ca | ||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0742-0528 | ISBN | Medium |
||
| Area | Expedition | Conference | |||
| Notes | PMID:22324558 | Approved | no | ||
| Call Number | IDA @ john @ | Serial | 138 | ||
| Permanent link to this record | |||||
| Author | Gooley, J.J.; Chamberlain, K.; Smith, K.A.; Khalsa, S.B.S.; Rajaratnam, S.M.W.; Van Reen, E.; Zeitzer, J.M.; Czeisler, C.A.; Lockley, S.W. | ||||
| Title | Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans | Type | Journal Article | ||
| Year | 2011 | Publication | The Journal of Clinical Endocrinology and Metabolism | Abbreviated Journal | J Clin Endocrinol Metab |
| Volume | 96 | Issue | 3 | Pages | E463-72 |
| Keywords | Adolescent; Adult; Female; Humans; *Light; *Lighting; Male; Melatonin/*blood; Sleep/physiology; Time Factors; Young Adult | ||||
| Abstract | CONTEXT: Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized. OBJECTIVE: We tested the hypothesis that exposure to room light in the late evening suppresses the onset of melatonin synthesis and shortens the duration of melatonin production. DESIGN: In a retrospective analysis, we compared daily melatonin profiles in individuals living in room light (<200 lux) vs. dim light (<3 lux). PATIENTS: Healthy volunteers (n = 116, 18-30 yr) were recruited from the general population to participate in one of two studies. SETTING: Participants lived in a General Clinical Research Center for at least five consecutive days. INTERVENTION: Individuals were exposed to room light or dim light in the 8 h preceding bedtime. OUTCOME MEASURES: Melatonin duration, onset and offset, suppression, and phase angle of entrainment were determined. RESULTS: Compared with dim light, exposure to room light before bedtime suppressed melatonin, resulting in a later melatonin onset in 99.0% of individuals and shortening melatonin duration by about 90 min. Also, exposure to room light during the usual hours of sleep suppressed melatonin by greater than 50% in most (85%) trials. CONCLUSIONS: These findings indicate that room light exerts a profound suppressive effect on melatonin levels and shortens the body's internal representation of night duration. Hence, chronically exposing oneself to electrical lighting in the late evening disrupts melatonin signaling and could therefore potentially impact sleep, thermoregulation, blood pressure, and glucose homeostasis. | ||||
| Address | Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA. gmsjjg@nus.edu | ||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0021-972X | ISBN | Medium |
||
| Area | Expedition | Conference | |||
| Notes | PMID:21193540; PMCID:PMC3047226 | Approved | no | ||
| Call Number | IDA @ john @ | Serial | 139 | ||
| Permanent link to this record | |||||
| Author | Cajochen, C.; Altanay-Ekici, S.; Munch, M.; Frey, S.; Knoblauch, V.; Wirz-Justice, A. | ||||
| Title | Evidence that the lunar cycle influences human sleep | Type | Journal Article | ||
| Year | 2013 | Publication | Current Biology : CB | Abbreviated Journal | Curr Biol |
| Volume | 23 | Issue | 15 | Pages | 1485-1488 |
| Keywords | Adult; Aged; Cross-Sectional Studies; Electroencephalography; Female; Humans; Hydrocortisone/analysis/metabolism; Male; Melatonin/analysis/metabolism; Middle Aged; Moon; Nontherapeutic Human Experimentation; Periodicity; Saliva/metabolism; Sleep/*physiology; Sleep Stages/physiology; Young Adult | ||||
| Abstract | Endogenous rhythms of circalunar periodicity ( approximately 29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1, 2]. In contrast, there is a great deal of folklore but no consistent association of moon cycles with human physiology and behavior [3]. Here we show that subjective and objective measures of sleep vary according to lunar phase and thus may reflect circalunar rhythmicity in humans. To exclude confounders such as increased light at night or the potential bias in perception regarding a lunar influence on sleep, we retrospectively analyzed sleep structure, electroencephalographic activity during non-rapid-eye-movement (NREM) sleep, and secretion of the hormones melatonin and cortisol found under stringently controlled laboratory conditions in a cross-sectional setting. At no point during and after the study were volunteers or investigators aware of the a posteriori analysis relative to lunar phase. We found that around full moon, electroencephalogram (EEG) delta activity during NREM sleep, an indicator of deep sleep, decreased by 30%, time to fall asleep increased by 5 min, and EEG-assessed total sleep duration was reduced by 20 min. These changes were associated with a decrease in subjective sleep quality and diminished endogenous melatonin levels. This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues. | ||||
| Address | Centre for Chronobiology, Psychiatric Hospital of the University of Basel, 4012 Basel, Switzerland. christian.cajochen@upkbs.ch | ||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0960-9822 | ISBN | Medium |
||
| Area | Expedition | Conference | |||
| Notes | PMID:23891110 | Approved | no | ||
| Call Number | IDA @ john @ | Serial | 140 | ||
| Permanent link to this record | |||||