| Records |
| Author |
Christie, S.; Vincent, A.D.; Li, H.; Frisby, C.L.; Kentish, S.J.; O'Rielly, R.; Wittert, G.A.; Page, A.J. |
| Title |
A rotating light cycle promotes weight gain and hepatic lipid storage in mice |
Type |
Journal Article |
| Year |
2018 |
Publication  |
American Journal of Physiology. Gastrointestinal and Liver Physiology |
Abbreviated Journal |
Am J Physiol Gastrointest Liver Physiol |
| Volume |
in press |
Issue |
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Pages |
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| Keywords |
Animals |
| Abstract |
Processes involved in regulation of energy balance and intermediary metabolism are aligned to the light-dark cycle. Shift-work and high fat diet (HFD)-induced obesity disrupt circadian rhythmicity and are associated with increased risk of non-alcoholic fatty liver disease (NAFLD). This study aimed to determine the effect of simulating shift work on hepatic lipid accumulation in lean and HFD-mice. C57BL/6 mice fed a standard laboratory diet (SLD) or HFD for 4wks were further allocated to a normal light (NL)-cycle (lights on:0600-1800hr) or rotating light (RL)-cycle (3-days NL and 4-days reversed (lights on:1800-0600hr) repeated) for 8wks. Tissue was collected every 3hrs beginning at 0600hr. HFD-mice gained more weight than SLD-mice, and RL-mice gained more weight than NL-mice. SLD-NL and HFD-NL mice, but not RL-mice, were more active, had higher respiratory quotients and consumed/expended more energy during the dark phase compared to the light phase. Blood glucose and plasma cholesterol and triglyceride concentrations were elevated in HFD and SLD-RL compared to SLD-NL mice. Hepatic glycogen was elevated in HFD compared to SLD-mice. Hepatic triglycerides were elevated in SLD-RL and HFD-mice compared to SLD-NL. Circadian rhythmicity of hepatic acetyl-CoA carboxylase (ACACA) mRNA was phase shifted in SLD-RL and HFD-NL and lost in HFD-RL mice. Hepatic ACACA protein was reduced in SLD-RL and HFD-mice compared to SLD-NL mice. Hepatic adipose triglyceride lipase was elevated in HFD-NL compared to SLD-NL but lower in RL-mice compared to NL-mice irrespective of diet. -Conclusion: A RL-cycle model of shift-work promotes weight gain and hepatic lipid storage even in lean conditions. |
| Address |
Adelaide Medical School, University of Adelaide, Australia |
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Place of Publication |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Series Issue |
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Edition |
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| ISSN |
0193-1857 |
ISBN |
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Conference |
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| Notes |
PMID:30188750 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
2123 |
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| Author |
Ruger, M.; Gordijn, M.C.M.; Beersma, D.G.M.; de Vries, B.; Daan, S. |
| Title |
Time-of-day-dependent effects of bright light exposure on human psychophysiology: comparison of daytime and nighttime exposure |
Type |
Journal Article |
| Year |
2006 |
Publication |
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology |
Abbreviated Journal |
Am J Physiol Regul Integr Comp Physiol |
| Volume |
290 |
Issue |
5 |
Pages |
R1413-20 |
| Keywords |
Human Health; Adult; Body Temperature/*physiology; Circadian Rhythm/*physiology; Fatigue/*physiopathology; Heart Rate/*physiology; Humans; Hydrocortisone/*blood; *Light; Sleep Stages/*physiology |
| Abstract |
Bright light can influence human psychophysiology instantaneously by inducing endocrine (suppression of melatonin, increasing cortisol levels), other physiological changes (enhancement of core body temperature), and psychological changes (reduction of sleepiness, increase of alertness). Its broad range of action is reflected in the wide field of applications, ranging from optimizing a work environment to treating depressed patients. For optimally applying bright light and understanding its mechanism, it is crucial to know whether its effects depend on the time of day. In this paper, we report the effects of bright light given at two different times of day on psychological and physiological parameters. Twenty-four subjects participated in two experiments (n = 12 each). All subjects were nonsmoking, healthy young males (18-30 yr). In both experiments, subjects were exposed to either bright light (5,000 lux) or dim light <10 lux (control condition) either between 12:00 P.M. and 4:00 P.M. (experiment A) or between midnight and 4:00 A.M. (experiment B). Hourly measurements included salivary cortisol concentrations, electrocardiogram, sleepiness (Karolinska Sleepiness Scale), fatigue, and energy ratings (Visual Analog Scale). Core body temperature was measured continuously throughout the experiments. Bright light had a time-dependent effect on heart rate and core body temperature; i.e., bright light exposure at night, but not in daytime, increased heart rate and enhanced core body temperature. It had no significant effect at all on cortisol. The effect of bright light on the psychological variables was time independent, since nighttime and daytime bright light reduced sleepiness and fatigue significantly and similarly. |
| Address |
Department of Chronobiology, University of Groningen, The Netherlands. Melanie.Rueger@med.nyu.edu |
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English |
Summary Language |
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Edition |
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| ISSN |
0363-6119 |
ISBN |
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| Notes |
PMID:16373441 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
801 |
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| Author |
Wright, K.P.J.; Hull, J.T.; Czeisler, C.A. |
| Title |
Relationship between alertness, performance, and body temperature in humans |
Type |
Journal Article |
| Year |
2002 |
Publication |
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology |
Abbreviated Journal |
Am J Physiol Regul Integr Comp Physiol |
| Volume |
283 |
Issue |
6 |
Pages |
R1370-7 |
| Keywords |
Human Health; Adult; Attention/*physiology; *Body Temperature; Circadian Rhythm/physiology; Cognition/*physiology; Female; Humans; Male; Memory/physiology; Reaction Time; Sleep/physiology; Time Factors; Wakefulness/physiology; NASA Discipline Regulatory Physiology; Non-NASA Center |
| Abstract |
Body temperature has been reported to influence human performance. Performance is reported to be better when body temperature is high/near its circadian peak and worse when body temperature is low/near its circadian minimum. We assessed whether this relationship between performance and body temperature reflects the regulation of both the internal biological timekeeping system and/or the influence of body temperature on performance independent of circadian phase. Fourteen subjects participated in a forced desynchrony protocol allowing assessment of the relationship between body temperature and performance while controlling for circadian phase and hours awake. Most neurobehavioral measures varied as a function of internal biological time and duration of wakefulness. A number of performance measures were better when body temperature was elevated, including working memory, subjective alertness, visual attention, and the slowest 10% of reaction times. These findings demonstrate that an increased body temperature, associated with and independent of internal biological time, is correlated with improved performance and alertness. These results support the hypothesis that body temperature modulates neurobehavioral function in humans. |
| Address |
Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. kenneth.wright@colorado.edu |
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English |
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0363-6119 |
ISBN |
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Conference |
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| Notes |
PMID:12388468 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
835 |
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| Author |
Stevens, R.G.; Brainard, G.C.; Blask, D.E.; Lockley, S.W.; Motta, M.E. |
| Title |
Adverse health effects of nighttime lighting: comments on American Medical Association policy statement |
Type |
Journal Article |
| Year |
2013 |
Publication |
American Journal of Preventive Medicine |
Abbreviated Journal |
Am J Prev Med |
| Volume |
45 |
Issue |
3 |
Pages |
343-346 |
| Keywords |
American Medical Association; Cell Cycle/physiology; Circadian Rhythm/*physiology; DNA Damage/physiology; *Health Policy; Humans; Lighting/*adverse effects; United States |
| Abstract |
The American Medical Association House of Delegates in June of 2012 adopted a policy statement on nighttime lighting and human health. This major policy statement summarizes the scientific evidence that nighttime electric light can disrupt circadian rhythms in humans and documents the rapidly advancing understanding from basic science of how disruption of circadian rhythmicity affects aspects of physiology with direct links to human health, such as cell cycle regulation, DNA damage response, and metabolism. The human evidence is also accumulating, with the strongest epidemiologic support for a link of circadian disruption from light at night to breast cancer. There are practical implications of the basic and epidemiologic science in the form of advancing lighting technologies that better accommodate human circadian rhythmicity. |
| Address |
University of Connecticut Health Center, Farmington, Connecticut 06030-6325, USA. bugs@uchc.edu |
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English |
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Series Issue |
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Edition |
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| ISSN |
0749-3797 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:23953362 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
130 |
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| Author |
Bender; D.J.; Bayne, E.M.; Brigham, R.M. |
| Title |
Lunar condition influences coyote (canis latrans) howling. |
Type |
Journal Article |
| Year |
1996 |
Publication |
American Midland Naturalist |
Abbreviated Journal |
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| Volume |
136 |
Issue |
2 |
Pages |
413-417 |
| Keywords |
Animals |
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Approved |
no |
| Call Number |
LoNNe @ christopher.kyba @ |
Serial |
413 |
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