toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author van der Burght, B.W.; Hansen, M.; Olsen, J.; Zhou, J.; Wu, Y.; Nissen, M.H.; Sparrow, J.R. url  doi
openurl 
  Title Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells Type Journal Article
  Year 2013 Publication (up) Acta Ophthalmologica Abbreviated Journal Acta Ophthalmol  
  Volume 91 Issue 7 Pages e537-45  
  Keywords Apoptosis; Cell Line; Cell Survival; Gene Expression Regulation/*physiology; Humans; Light; Lipofuscin/genetics; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Pyridinium Compounds; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Retinal Pigment Epithelium/metabolism/pathology/*radiation effects; Retinoids/*genetics; Transcriptome; A2e; age-related macular degeneration; apoptosis; complement cascade; gene expression; retinal pigment epithelial cells; blue light; retinal pigment epithelial; epigenetics  
  Abstract PURPOSE: Accumulation of bisretinoids as lipofuscin in retinal pigment epithelial (RPE) cells is implicated in the pathogenesis of some blinding diseases including age-related macular degeneration (AMD). To identify genes whose expression may change under conditions of bisretinoid accumulation, we investigated the differential gene expression in RPE cells that had accumulated the lipofuscin fluorophore A2E and were exposed to blue light (430 nm). METHODS: A2E-laden RPE cells were exposed to blue light (A2E/430 nm) at various time intervals. Cell death was quantified using Dead Red staining, and RNA levels for the entire genome was determined using DNA microarrays (Affymetrix GeneChip Human Genome 2.0 Plus). Array results for selected genes were confirmed by real-time reverse-transcriptase polymerase chain reaction. RESULTS: Principal component analysis revealed that the A2E-laden RPE cells irradiated with blue light were clearly distinguishable from the control samples. We found differential regulation of genes belonging to the following functional groups: transcription factors, stress response, apoptosis and immune response. Among the last mentioned were downregulation of four genes that coded for proteins that have an inhibitory effect on the complement cascade: (complement factor H, complement factor H-related 1, complement factor I and vitronectin) and of two belonging to the classical pathway (complement component 1, s subcomponent and complement component 1, r subcomponent). CONCLUSION: This study demonstrates that blue light irradiation of A2E-laden RPE cells can alter the transcription of genes belonging to different functional pathways including stress response, apoptosis and the immune response. We suggest that these molecules may be associated to the pathogenesis of AMD and can potentially serve as future therapeutic targets.  
  Address Department of International Health, Immunology and Microbiology, Eye Research Unit, University of Copenhagen, Copenhagen, DenmarkDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, DenmarkDepartment of Ophthalmology, Columbia University, New York, New York, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1755-375X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23742627 Approved no  
  Call Number IDA @ john @ Serial 346  
Permanent link to this record
 

 
Author Kwak, M.J.; Lee, S.H.; Khaine, I.; Je, S.M.; Lee, T.Y.; You, H.N.; Lee, H.K.; Jang, J.H.; Kim, I.; Woo, S.Y. url  doi
openurl 
  Title Stomatal movements depend on interactions between external night light cue and internal signals activated by rhythmic starch turnover and abscisic acid (ABA) levels at dawn and dusk Type Journal Article
  Year 2017 Publication (up) Acta Physiologiae Plantarum Abbreviated Journal Acta Physiol Plant  
  Volume 39 Issue 8 Pages  
  Keywords Plants  
  Abstract Yellow poplar (Liriodendron tulipifera L.) is a widespread hardwood tree of great ecological and economic value. Light pollution caused by excessive and indiscriminate exposure to artificial night light has emerged as a new risk factor due to its adverse effects related to energy waste, sleep disorders, anthropogenic habitat disturbance, and perceptual disorder of daily and seasonal rhythms in wildlife. However, it remains unknown how associations between artificial night light and stomatal behaviors controlled by internal signals are established. After continuous exposure to artificial light at night over 3 years, leaves in the experimental set-up were measured for stomatal movements, starch turnover, endogenous abscisic acid (ABA) levels, and chloroplast ultrastructure during the growing season. Yellow poplar showed dynamic changes in stomatal movement, starch turnover, and endogenous ABA levels in response to day/artificial night light cycle, resulting in reduction of circadian phase-shifting capacity at both dusk and dawn and normal chloroplast development as compared with natural night. Nighttime light exposure may act as a major factor for disorder of circadian and circannual rhythms as well as physiological and ultrastructural repressor in plants, via a modification of the perceived photoperiod. Our study suggests that these dynamic responses can provide advantageous insights that complement the current knowledge on light pollution.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0137-5881 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1682  
Permanent link to this record
 

 
Author Te Kulve, M.; Schellen, L.; Schlangen, L.J.; van Marken Lichtenbelt, W.D. url  doi
openurl 
  Title The influence of light on thermal responses Type Journal Article
  Year 2015 Publication (up) Acta Physiologica (Oxford, England) Abbreviated Journal Acta Physiol (Oxf)  
  Volume 216 Issue 2 Pages 163–185  
  Keywords Phsychology; Human Health  
  Abstract Light is essential for vision and plays an important role in non-visual responses, thus affecting alertness, mood and circadian rhythms. Furthermore, light influences physiological processes, such as thermoregulation, and therefore may be expected to play a role in thermal comfort as well. A systematic literature search was performed for human studies exploring the relation between ocular light exposure, thermophysiology and thermal comfort. Experimental results show that light in the evening can reduce melatonin secretion, delay the natural decline in core body temperature (CBT), and slow down the increase in distal skin temperature. In the morning though, bright light can result in a faster decline of melatonin levels, thus enabling a faster increase in CBT. Moreover the colour of light can affect temperature perception of the environment. Light with colour tones towards the red-end of the visual spectrum leads to a warmer perception compared to more bluish light tones. It should be noted however, that many results of light on thermal responses are inconclusive, and a theoretical framework is largely lacking. In conclusion, light is capable of evoking thermophysiological responses and visual input can alter perception of the thermal environment. Therefore lighting conditions should be taken in consideration during thermophysiological research and in the design of indoor climates. This article is protected by copyright. All rights reserved.  
  Address Department of Human Biology, NUTRIM, Maastricht University  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1748-1708 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26172218 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1208  
Permanent link to this record
 

 
Author Muller, A.; Gal, N.; Betlehem, J.; Fuller, N.; Acs, P.; Kovacs, G.; Fusz, K.; Jozsa, R.; Olah, A. url  doi
openurl 
  Title Examination of the interaction of different lighting conditions and chronic mild stress in animal model Type Journal Article
  Year 2015 Publication (up) Acta Physiologica Hungarica Abbreviated Journal Acta Physiologica Hungarica  
  Volume 102 Issue 3 Pages 301-310  
  Keywords animals; health  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0231-424X ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1275  
Permanent link to this record
 

 
Author Beck, W.; Gobatto, C. url  doi
openurl 
  Title Effect of high wavelengths low intensity light during dark period on physical exercise performance, biochemical and haematological parameters of swimming rats Type Journal Article
  Year 2016 Publication (up) Acta Physiologica Hungarica Abbreviated Journal Acta Physiol Hung  
  Volume 103 Issue 1 Pages 112-120  
  Keywords Animals  
  Abstract Nocturnal rodents should be assessed at an appropriate time of day, which leads to a challenge in identifying an adequate environmental light which allows animal visualisation without perturbing physiological homeostasis. Thus, we analysed the influence of high wavelength and low intensity light during dark period on physical exercise and biochemical and haematological parameters of nocturnal rats. We submitted 80 animals to an exhaustive exercise at individualised intensity under two different illuminations during dark period. Red light (> 600 nm; < 15lux) was applied constantly during dark period (EI; for experimental illumination groups) or only for handling and assessments (SI; for standard illumination groups). EI led to worse haematological and biochemical conditions, demonstrating that EI alone can influence physiological parameters and jeopardise result interpretation. SI promotes normal physiological conditions and greater aerobic tolerance than EI, showing the importance of a correct illumination pattern for all researchers that employ nocturnal rats for health/disease or sports performance experiments.  
  Address Laboratory of Applied Sport Physiology, School of Physical Education, University of Campinas , Sao Paulo , Brasil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0231-424X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27030633 Approved no  
  Call Number LoNNe @ kyba @ Serial 1410  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: