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Author Shimomura, M.; Yoshida, H.; Fujiuchi, N.; Ariizumi, T.; Ezura, H.; Fukuda, N. url  doi
openurl 
  Title Continuous blue lighting and elevated carbon dioxide concentration rapidly increase chlorogenic acid content in young lettuce plants Type Journal Article
  Year 2020 Publication Scientia Horticulturae Abbreviated Journal Scientia Horticulturae  
  Volume 272 Issue Pages 109550  
  Keywords Plants  
  Abstract Chlorogenic acid (CGA) is a strong antioxidant that potentially reduces oxidative damage in human cells. In this study, the effects of environmental factors such as photoperiod, light quality and intensity, and CO2 concentration on the growth and CGA content of lettuce (Lactuca sativa L.) were evaluated. CGA content in fresh lettuce increased under high light intensity treatments, doubling in concentration under 200 μmol m−2 s-1 compared to 100 μmol m−2 s-1. Elevated CO2 concentration also increased CGA content in fresh lettuce, quadrupling in concentration when grown at 1000 ppm compared to 400 ppm. Furthermore, there was a compound effect of light intensity and CO2 concentration whereby a light intensity level of 200 μmol m−2 s-1 and CO2 of 1000 ppm produced an even higher concentration of CGA, 199 mg per 100 g of fresh lettuce. Increased CGA concentration because of continuous lighting and elevated CO2 was observed under both fluorescent light and blue LED, but not under red LED treatment. Increased day length also induced higher CGA content in lettuce plants. These results show that continuous lighting, including blue spectrum and elevated CO2 concentration can cause higher CGA accumulation in lettuce plants. The observed increase in CGA content was induced only for 2 days after treatment was initiated. One possible interpretation of the data is that physiological stress caused by excess photosynthesis under continuous lighting results in higher CGA content to protect the plant body from high levels of reactive oxidative species. In addition, blue light and CO2 could be stimulus signals for inducing high CGA accumulation via metabolite changes.  
  Address  
  Corporate Author Thesis  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0304-4238 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3090  
Permanent link to this record
 

 
Author Weil, Z.M.; Fonken, L.K.; Walker, W.H. 2nd; Bumgarner, J.R.; Liu, J.A.; Melendez-Fernandez, O.H.; Zhang, N.; DeVries, A.C.; Nelson, R.J. url  doi
openurl 
  Title Dim Light at Night Exacerbates Stroke Outcome Type Journal Article
  Year 2020 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume in press Issue Pages in press  
  Keywords Animals; Mcao; circadian rhythms; cytokines; light pollution; neuroinflammation; stroke  
  Abstract Circadian rhythms are endogenous biological cycles that synchronize physiology and behavior to promote optimal function. These ~24-hour internal rhythms are set to precisely 24 hours daily by exposure to the sun. However, the prevalence of night-time lighting has the potential to dysregulate these biological functions. Hospital patients may be particularly vulnerable to the consequences of light at night because of their compromised physiological state. A mouse model of stroke (middle cerebral artery occlusion; MCAO) was used to test the hypothesis that exposure to dim light at night impairs responses to a major insult. Stroke lesion size was substantially larger among animals housed in dLAN after reperfusion than animals maintained in dark nights. Mice housed in dLAN for three days after the stroke displayed increased post-stroke anxiety-like behavior. Overall, dLAN amplified pro-inflammatory pathways in the CNS, which may have exacerbated neuronal damage. Our results suggest that exposure to LAN is detrimental to stroke recovery.  
  Address Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV, 26506, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32691462 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3089  
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Author Feng, Z.; Peng, J.; Wu, J. url  doi
openurl 
  Title Using DMSP/OLS nighttime light data and K–means method to identify urban–rural fringe of megacities Type Journal Article
  Year 2020 Publication Habitat International Abbreviated Journal Habitat International  
  Volume 103 Issue Pages 102227  
  Keywords Remote Sensing  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0197-3975 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3087  
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Author Xie, C.; Zhu, H.; Chen, S.; Wen, Y.; Jin, L.; Zhang, L.; Tong, J.; Shen, Y. url  doi
openurl 
  Title Chronic retinal injury induced by white LED light with different correlated color temperatures as determined by microarray analyses of genome-wide expression patterns in mice Type Journal Article
  Year 2020 Publication Journal of Photochemistry and Photobiology. B, Biology Abbreviated Journal J Photochem Photobiol B  
  Volume 210 Issue Pages 111977  
  Keywords Animals; Vision; Autophagy; Cct; Expression profile microarray; Genome-wide; Led; Retinal photoreceptor degeneration; Ubiquitin  
  Abstract Widely used white light-emitting diodes (LEDs) currently deliver higher levels of blue light than conventional domestic light sources. The high intensity of the blue component is the main source of concern regarding possible health risks of LED to chronic light toxicity to the retina. Therefore, we analyzed retinal injury and genome-wide changes in gene expression induced by white LED light with different correlated color temperatures (CCTs) in a mouse model. Balb/c mice (10 weeks old) were exposed to LED light with CCTs of 2954, 5624, and 7378 K, at different illuminance levels (250, 500, 1000, and 3000 lx) and for different exposure times (7, 14, and 28 days). Hematoxylin and eosin staining revealed that exposure to 7378 K light at 250 lx for 28 days resulted in a significant reduction of outer nuclear layer (ONL) nuclei, whereas 2954 K light at <3000 lx led to only a mild reduction in the number of ONL nuclei. In addition, 5624 and 7378 K light at 3000 lx resulted in a significant increase in TUNEL-positive apoptotic nuclei, which was not found at an illuminance of 1000 lx. Genome-wide expression analyses showed that, compared to a control group, there were 121 upregulated differentially expressed genes (DEGs) and 458 downregulated DEGs found in the 7378 K group, and 59 upregulated and only 4 downregulated DEGs in the 2954 K group. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that the DEGs were involved in 341 GO terms and 16 related pathways for the 7378 K group and in 12 GO terms and 7 related pathways for the 2954 K group. Signal pathways related to ubiquitin potentially played an important role in light-induced retinal degeneration. Furthermore, retinal immunohistochemistry (IHC) indicated downregulation of ubiquitin and autophagy function caused by 7378 K light. Taken together, these results indicate that retinal injury in the mice induced by white LED light occurred in a CCT-dependent manner, and that light with a higher CCT was more likely to reduce ONL nuclei; however, the apoptosis pathway may not be the only mechanism involved. Based on genome-wide expression analyses and retinal IHC, the ubiquitin-mediated proteolysis signal pathway may have participated in the induction retinal degeneration.  
  Address Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: idrshen@zju.edu.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1011-1344 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32738749 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3086  
Permanent link to this record
 

 
Author Prabhat, A.; Malik, I.; Jha, N.A.; Bhardwaj, S.K.; Kumar, V. url  doi
openurl 
  Title Developmental effects of constant light on circadian behaviour and gene expressions in zebra finches: Insights into mechanisms of metabolic adaptation to aperiodic environment in diurnal animals Type Journal Article
  Year 2020 Publication Journal of Photochemistry and Photobiology B: Biology Abbreviated Journal Journal of Photochemistry and Photobiology B: Biology  
  Volume in press Issue Pages 111995  
  Keywords Animals  
  Abstract A most crucial feature of biological adaptation is the maintenance of a close temporal relationship of behaviour and physiology with prevailing 24-h light-dark environment, which is rapidly changing with increasing nighttime illumination. This study investigated developmental effects of the loss of night on circadian behaviour, metabolism and gene expressions in diurnal zebra finches born and raised under LL, with controls on 12 L:12D. Birds under LD were entrained, and showed normal body mass and a significant 24-h rhythm in both activity-rest pattern and mRNA expression of candidate genes that we measured. But, under LL, birds gained weight and accumulated lipid in the liver. Intriguingly, at the end of the experiment, the majority (4/5th) of birds under LL were rhythmic in activity despite arrhythmic expression in the hypothalamus of c-Fos (neuronal activity), Rhodopsin and Mel1-a genes (light perception), and clock genes (Bmal1, Per2 and Rev-erb β). In peripheral tissues, LL induced variable clock gene expressions. Whereas 24-h mRNA rhythm was abolished for Bmal1 in both liver and gut, it persisted for Per2 and Rev-erb β in liver, and for Per2 in gut. Further, we found under LL, the loss of 24-h rhythm in hepatic expression of Fasn and Cd36/Fat (biosynthesis and its uptake), and gut expression of Sglt1, Glut5, Cd36 and Pept1 (nutrient absorption) genes. As compared to LD, baseline mRNA levels of Fasn and Cd36 genes were attenuated under LL. Among major transporter genes, Sglt1 (glucose) and Cd36 (fat) genes were arrhythmic, while Glut5 (glucose) and Pept1 (protein) genes were rhythmic but with phase differences under LL, compared to LD. These results demonstrate dissociation of circadian behaviour from clock gene rhythms, and provide molecular insights into possible mechanisms at different levels (behaviour and physiology) that diurnal animals might employ in order to adapt to an emerging overly illuminated-night urban environment.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1011-1344 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3085  
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