|
Records |
Links |
|
Author |
Parent, M.-E.; El-Zein, M.; Rousseau, M.-C.; Pintos, J.; Siemiatycki, J. |

|
|
Title |
Night work and the risk of cancer among men |
Type |
Journal Article |
|
Year |
2012 |
Publication |
American Journal of Epidemiology |
Abbreviated Journal |
Am J Epidemiol |
|
|
Volume |
176 |
Issue |
9 |
Pages |
751-759 |
|
|
Keywords |
Adult; Aged; *Circadian Rhythm; Humans; Male; *Men's Health; Middle Aged; Neoplasms/*epidemiology; Occupations/*statistics & numerical data; Personnel Staffing and Scheduling/*statistics & numerical data; Quebec/epidemiology; Risk Factors; oncogenesis |
|
|
Abstract |
Night work might influence cancer risk, possibly via suppression of melatonin release. In a population-based case-control study conducted in Montreal, Quebec, Canada, between 1979 and 1985, job histories, including work hours, were elicited from 3,137 males with incident cancer at one of 11 anatomic sites and from 512 controls. Compared with men who never worked at night, the adjusted odds ratios among men who ever worked at night were 1.76 (95% confidence interval (CI): 1.25, 2.47) for lung cancer, 2.03 (95% CI: 1.43, 2.89) for colon cancer, 1.74 (95% CI: 1.22, 2.49) for bladder cancer, 2.77 (95% CI: 1.96, 3.92) for prostate cancer, 2.09 (95% CI: 1.40, 3.14) for rectal cancer, 2.27 (95% CI: 1.24, 4.15) for pancreatic cancer, and 2.31 (95% CI: 1.48, 3.61) for non-Hodgkin's lymphoma. Equivocal evidence or no evidence was observed for cancers of the stomach (odds ratio (OR) = 1.34, 95% CI: 0.85, 2.10), kidney (OR = 1.42, 95% CI: 0.86, 2.35), and esophagus (OR = 1.51, 95% CI: 0.80, 2.84) and for melanoma (OR = 1.04, 95% CI: 0.49, 2.22). There was no evidence of increasing risk with increasing duration of night work, with risks generally being increased across all duration categories. Results suggest that night work may increase cancer risk at several sites among men. |
|
|
Address |
INRS-Institut Armand-Frappier, University of Quebec, Laval, Canada. marie-elise.parent@iaf.inrs.ca |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume  |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0002-9262 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:23035019 |
Approved |
no |
|
|
Call Number |
IDA @ john @ |
Serial |
158 |
|
Permanent link to this record |
|
|
|
|
Author |
Peplonska, B.; Bukowska, A.; Sobala, W.; Reszka, E.; Gromadzinska, J.; Wasowicz, W.; Lie, J.A.; Kjuus, H.; Ursin, G. |

|
|
Title |
Rotating night shift work and mammographic density |
Type |
Journal Article |
|
Year |
2012 |
Publication |
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology |
Abbreviated Journal |
Cancer Epidemiol Biomarkers Prev |
|
|
Volume |
21 |
Issue |
7 |
Pages |
1028-1037 |
|
|
Keywords |
Adult; Breast/*pathology; Breast Neoplasms/*etiology/*pathology; Circadian Rhythm/*physiology; Cross-Sectional Studies; Female; Humans; Melatonin/urine; Middle Aged; *Midwifery; *Nursing Staff; Questionnaires; Risk Factors; *Work Schedule Tolerance; oncogenesis |
|
|
Abstract |
BACKGROUND: An increased risk of breast cancer has been observed in night shift workers. Exposure to artificial light at night and disruption of the endogenous circadian rhythm with suppression of the melatonin synthesis have been suggested mechanisms. We investigated the hypothesis that rotating night shift work is associated with mammographic density. METHODS: We conducted a cross-sectional study on the association between rotating night shift work characteristics, 6-sulfatoxymelatonin (MT6s) creatinine adjusted in a spot morning urine sample, and a computer-assisted measure of mammographic density in 640 nurses and midwives ages 40 to 60 years. The associations were evaluated using regression models adjusted for age, body mass index, menopausal status, age at menopause, age at menarche, smoking, and the calendar season of the year when mammography was conducted. RESULTS: The adjusted means of percentage of mammographic density and absolute density were slightly higher among women working rotating night shifts but not statistically significant [percentage of mammographic density = 23.6%, 95% confidence interval (CI), 21.9%-25.4% vs. 22.5%, 95% CI, 20.8%-24.3%; absolute density = 23.9 cm(2), 95% CI, 21.4-26.4 cm(2) vs. 21.8 cm(2), 95% CI, 19.4-24.3 cm(2) in rotating night shift and day shift nurses, respectively). There were no significant associations between the current or cumulative rotating night shift work exposure metrics and mammographic density. No association was observed between morning MT6s and mammographic density. CONCLUSIONS: The hypothesis on the link between rotating night shift work, melatonin synthesis disruption, and mammographic density is not supported by the results of the present study. IMPACT: It is unlikely that the development of breast cancer in nurses working rotating night shifts is mediated by an increase in mammographic density. |
|
|
Address |
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland. beatap@imp.lodz.pl |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume  |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
1055-9965 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:22539602 |
Approved |
no |
|
|
Call Number |
IDA @ john @ |
Serial |
159 |
|
Permanent link to this record |
|
|
|
|
Author |
Kloog, I.; Stevens, R.G.; Haim, A.; Portnov, B.A. |

|
|
Title |
Nighttime light level co-distributes with breast cancer incidence worldwide |
Type |
Journal Article |
|
Year |
2010 |
Publication |
Cancer Causes & Control : CCC |
Abbreviated Journal |
Cancer Causes Control |
|
|
Volume |
21 |
Issue |
12 |
Pages |
2059-2068 |
|
|
Keywords |
Adult; Birth Rate; Breast Neoplasms/*epidemiology/etiology; Carcinoma/*epidemiology/etiology; Circadian Rhythm/*physiology; Cohort Studies; Electricity; Female; Humans; Incidence; *Light/adverse effects; Lighting; Photoperiod; Registries; Urban Population/statistics & numerical data; World Health; oncogenesis |
|
|
Abstract |
Breast cancer incidence varies widely among countries of the world for largely unknown reasons. We investigated whether country-level light at night (LAN) is associated with incidence. We compared incidence rates of five common cancers in women (breast, lung, colorectal, larynx, and liver), observed in 164 countries of the world from the GLOBOCAN database, with population-weighted country-level LAN, and with several developmental and environmental indicators, including fertility rate, per capita income, percent of urban population, and electricity consumption. Two types of regression models were used in the analysis: Ordinary Least Squares and Spatial Errors. We found a significant positive association between population LAN level and incidence rates of breast cancer. There was no such an association between LAN level and colorectal, larynx, liver, and lung cancers. A sensitivity test, holding other variables at their average values, yielded a 30-50% higher risk of breast cancer in the highest LAN exposed countries compared to the lowest LAN exposed countries. The possibility that under-reporting from the registries in the low-resource, and also low-LAN, countries created a spurious association was evaluated in several ways and shown not to account for the results. These findings provide coherence of the previously reported case-control and cohort studies with the co-distribution of LAN and breast cancer in entire populations. |
|
|
Address |
Department of Natural Resources & Environmental Management, University of Haifa, 31905 Mount Carmel, Haifa, Israel |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume  |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0957-5243 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:20680434 |
Approved |
no |
|
|
Call Number |
IDA @ john @ |
Serial |
160 |
|
Permanent link to this record |
|
|
|
|
Author |
Li, Q.; Zheng, T.; Holford, T.R.; Boyle, P.; Zhang, Y.; Dai, M. |

|
|
Title |
Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA |
Type |
Journal Article |
|
Year |
2010 |
Publication |
Cancer Causes & Control : CCC |
Abbreviated Journal |
Cancer Causes Control |
|
|
Volume |
21 |
Issue |
12 |
Pages |
2281-2285 |
|
|
Keywords |
Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology; Carcinoma/epidemiology/*etiology; Case-Control Studies; Circadian Rhythm/physiology; Connecticut/epidemiology; Female; Humans; *Light/adverse effects; Middle Aged; Population; Questionnaires; Risk Factors; United States/epidemiology; Work Schedule Tolerance/physiology; Oncogenesis |
|
|
Abstract |
OBJECTIVE: To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer. METHODS: A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression. RESULTS: A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9). CONCLUSION: The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results. |
|
|
Address |
Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume  |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0957-5243 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:20927578; PMCID:PMC3154700 |
Approved |
no |
|
|
Call Number |
IDA @ john @ |
Serial |
161 |
|
Permanent link to this record |
|
|
|
|
Author |
Yasuniwa, Y.; Izumi, H.; Wang, K.-Y.; Shimajiri, S.; Sasaguri, Y.; Kawai, K.; Kasai, H.; Shimada, T.; Miyake, K.; Kashiwagi, E.; Hirano, G.; Kidani, A.; Akiyama, M.; Han, B.; Wu, Y.; Ieiri, I.; Higuchi, S.; Kohno, K. |

|
|
Title |
Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway |
Type |
Journal Article |
|
Year |
2010 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
|
|
Volume |
5 |
Issue |
12 |
Pages |
e15330 |
|
|
Keywords |
Animals; *Circadian Rhythm; Disease Progression; *Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms/*pathology; *Neovascularization, Pathologic; Nerve Tissue Proteins/metabolism; Skin/metabolism; Vascular Endothelial Growth Factor A/metabolism; Wnt Proteins/*metabolism; Oncogenesis |
|
|
Abstract |
Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more “normal” 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway. |
|
|
Address |
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume  |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
1932-6203 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:21203463; PMCID:PMC3009728 |
Approved |
no |
|
|
Call Number |
IDA @ john @ |
Serial |
162 |
|
Permanent link to this record |