| |
Records |
Links |
|
Author |
Kloog, I.; Stevens, R.G.; Haim, A.; Portnov, B.A. |
|
| |
Title |
Nighttime light level co-distributes with breast cancer incidence worldwide |
Type |
Journal Article |
| |
Year |
2010 |
Publication |
Cancer Causes & Control : CCC |
Abbreviated Journal |
Cancer Causes Control |
|
| |
Volume |
21 |
Issue |
12 |
Pages |
2059-2068 |
|
| |
Keywords |
Adult; Birth Rate; Breast Neoplasms/*epidemiology/etiology; Carcinoma/*epidemiology/etiology; Circadian Rhythm/*physiology; Cohort Studies; Electricity; Female; Humans; Incidence; *Light/adverse effects; Lighting; Photoperiod; Registries; Urban Population/statistics & numerical data; World Health; oncogenesis |
|
| |
Abstract |
Breast cancer incidence varies widely among countries of the world for largely unknown reasons. We investigated whether country-level light at night (LAN) is associated with incidence. We compared incidence rates of five common cancers in women (breast, lung, colorectal, larynx, and liver), observed in 164 countries of the world from the GLOBOCAN database, with population-weighted country-level LAN, and with several developmental and environmental indicators, including fertility rate, per capita income, percent of urban population, and electricity consumption. Two types of regression models were used in the analysis: Ordinary Least Squares and Spatial Errors. We found a significant positive association between population LAN level and incidence rates of breast cancer. There was no such an association between LAN level and colorectal, larynx, liver, and lung cancers. A sensitivity test, holding other variables at their average values, yielded a 30-50% higher risk of breast cancer in the highest LAN exposed countries compared to the lowest LAN exposed countries. The possibility that under-reporting from the registries in the low-resource, and also low-LAN, countries created a spurious association was evaluated in several ways and shown not to account for the results. These findings provide coherence of the previously reported case-control and cohort studies with the co-distribution of LAN and breast cancer in entire populations. |
|
| |
Address |
Department of Natural Resources & Environmental Management, University of Haifa, 31905 Mount Carmel, Haifa, Israel |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume  |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0957-5243 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:20680434 |
Approved |
no |
|
| |
Call Number |
IDA @ john @ |
Serial |
160 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Li, Q.; Zheng, T.; Holford, T.R.; Boyle, P.; Zhang, Y.; Dai, M. |
|
| |
Title |
Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA |
Type |
Journal Article |
| |
Year |
2010 |
Publication |
Cancer Causes & Control : CCC |
Abbreviated Journal |
Cancer Causes Control |
|
| |
Volume |
21 |
Issue |
12 |
Pages |
2281-2285 |
|
| |
Keywords |
Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology; Carcinoma/epidemiology/*etiology; Case-Control Studies; Circadian Rhythm/physiology; Connecticut/epidemiology; Female; Humans; *Light/adverse effects; Middle Aged; Population; Questionnaires; Risk Factors; United States/epidemiology; Work Schedule Tolerance/physiology; Oncogenesis |
|
| |
Abstract |
OBJECTIVE: To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer. METHODS: A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression. RESULTS: A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9). CONCLUSION: The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results. |
|
| |
Address |
Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0957-5243 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:20927578; PMCID:PMC3154700 |
Approved |
no |
|
| |
Call Number |
IDA @ john @ |
Serial |
161 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Yasuniwa, Y.; Izumi, H.; Wang, K.-Y.; Shimajiri, S.; Sasaguri, Y.; Kawai, K.; Kasai, H.; Shimada, T.; Miyake, K.; Kashiwagi, E.; Hirano, G.; Kidani, A.; Akiyama, M.; Han, B.; Wu, Y.; Ieiri, I.; Higuchi, S.; Kohno, K. |
|
| |
Title |
Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway |
Type |
Journal Article |
| |
Year |
2010 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
|
| |
Volume |
5 |
Issue |
12 |
Pages |
e15330 |
|
| |
Keywords |
Animals; *Circadian Rhythm; Disease Progression; *Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms/*pathology; *Neovascularization, Pathologic; Nerve Tissue Proteins/metabolism; Skin/metabolism; Vascular Endothelial Growth Factor A/metabolism; Wnt Proteins/*metabolism; Oncogenesis |
|
| |
Abstract |
Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more “normal” 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway. |
|
| |
Address |
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1932-6203 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:21203463; PMCID:PMC3009728 |
Approved |
no |
|
| |
Call Number |
IDA @ john @ |
Serial |
162 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Kloog, I.; Haim, A.; Stevens, R.G.; Portnov, B.A. |
|
| |
Title |
Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men |
Type |
Journal Article |
| |
Year |
2009 |
Publication |
Chronobiology International |
Abbreviated Journal |
Chronobiol Int |
|
| |
Volume |
26 |
Issue |
1 |
Pages |
108-125 |
|
| |
Keywords |
Circadian Rhythm; Colonic Neoplasms/*epidemiology; Electricity; Humans; Incidence; *Light; Lung Neoplasms/*epidemiology; Male; Prostatic Neoplasms/*epidemiology; Risk Factors; Urban Population; World Health; Oncogenesis |
|
| |
Abstract |
The incidence rates of cancers in men differ by countries of the world. We compared the incidence rates of three of the most common cancers (prostate, lung, and colon) in men residing in 164 different countries with the population-weighted light at night (LAN) exposure and with several developmental and environmental indicators, including per capita income, percent urban population, and electricity consumption. The estimate of per capita LAN exposure was a novel aspect of this study. Both ordinary least squares (OLS) and spatial error (SE) regression models were used in the analysis. We found a significant positive association between population exposure to LAN and incidence rates of prostate cancer, but no such association with lung cancer or colon cancer. The prostate cancer result is consistent with a biological theory and a limited number of previous studies of circadian disruption and risk. The LAN-prostate cancer connection is postulated to be due to suppression of melatonin and/or disruption of clock gene function. An analysis holding other variables at average values across the 164 countries yielded a risk of prostate cancer in the highest LAN-exposed countries 110% higher than in the lowest LAN exposed countries. This observed association is a necessary condition for a potentially large effect of LAN on risk of prostate cancer. However, it is not sufficient due to potential confounding by factors that increase the risk of prostate cancer and are also associated with LAN among the studied countries. |
|
| |
Address |
Department of Natural Resources & Environmental Management, Faculty of Social Sciences, University of Haifa, Haifa, Israel |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0742-0528 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:19142761 |
Approved |
no |
|
| |
Call Number |
IDA @ john @ |
Serial |
163 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Davis, S.; Mirick, D.K.; Stevens, R.G. |
|
| |
Title |
Night Shift Work, Light at Night, and Risk of Breast Cancer |
Type |
Journal Article |
| |
Year |
2001 |
Publication |
JNCI Journal of the National Cancer Institute |
Abbreviated Journal |
JNCI Journal of the National Cancer Institute |
|
| |
Volume |
93 |
Issue |
20 |
Pages |
1557-1562 |
|
| |
Keywords |
light at night; oncogenesis; melatonin; shiftwork; breast cancer; *Cancer |
|
| |
Abstract |
Exposure to light at night may increase the risk of breast cancer by suppressing the normal nocturnal production of melatonin by the pineal gland, which, in turn, could increase the release of estrogen by the ovaries. This study investigated whether such exposure is associated with an increased risk of breast cancer in women. Methods: Case patients (n = 813), aged 20–74 years, were diagnosed from November 1992 through March 1995; control subjects (n = 793) were identified by random-digit dialing and were frequency matched according to 5-year age groups. An in-person interview was used to gather information on sleep habits and bedroom lighting environment in the 10 years before diagnosis and lifetime occupational history. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by use of conditional logistic regression, with adjustment for other potential risk factors. Results: Breast cancer risk was increased among subjects who frequently did not sleep during the period of the night when melatonin levels are typically at their highest (OR = 1.14 for each night per week; 95% CI = 1.01 to 1.28). Risk did not increase with interrupted sleep accompanied by turning on a light. There was an indication of increased risk among subjects with the brightest bedrooms. Graveyard shiftwork was associated with increased breast cancer risk (OR = 1.6; 95% CI = 1.0 to 2.5), with a trend of increased risk with increasing years and with more hours per week of graveyard shiftwork (P = .02, Wald chi-squared test). Conclusion: The results of this study provide evidence that indicators of exposure to light at night may be associated with the risk of developing breast cancer. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0027-8874 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
IDA @ john @ |
Serial |
164 |
|
| Permanent link to this record |
