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Author Berson, D.M.; Dunn, F.A.; Takao, M.
Title Phototransduction by retinal ganglion cells that set the circadian clock Type Journal Article
Year 2002 Publication Science (New York, N.Y.) Abbreviated Journal Science
Volume (down) 295 Issue 5557 Pages 1070-1073
Keywords Human Health; Animals; Axons/ultrastructure; *Biological Clocks; *Circadian Rhythm; Dendrites/ultrastructure; Isoquinolines; Kinetics; Light; *Light Signal Transduction; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells/chemistry/cytology/*physiology; Rod Opsins/analysis/physiology; Suprachiasmatic Nucleus/cytology/*physiology
Abstract Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.
Address Department of Neuroscience, Brown University, Providence, RI, 02912 USA. David_Berson@brown.edu
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ISSN 0036-8075 ISBN Medium
Area Expedition Conference
Notes PMID:11834835 Approved no
Call Number LoNNe @ kagoburian @ Serial 720
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Author Hogan, M.K.; Kovalycsik, T.; Sun, Q.; Rajagopalan, S.; Nelson, R.J.
Title Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice Type Journal Article
Year 2015 Publication Behavioural Brain Research Abbreviated Journal Behav Brain Res
Volume (down) 294 Issue Pages 81-88
Keywords Animals
Abstract Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has been implicated in several CNS disorders. The combinatorial role of these pollutants on health outcomes has not been assessed. Male C3H/HeNHsd mice, with intact melatonin production, were used to model humans exposed to circadian disruption by dLAN and contaminated environmental air. We hypothesized exposure to 2.5mum of particulate matter (PM2.5) and dLAN (5lx) combines to upregulate neuroinflammatory cytokine expression and alter hippocampal morphology compared to mice exposed to filtered air (FA) and housed under dark nights (LD). We also hypothesized that exposure to PM2.5 and dLAN provokes anxiety-like and depressive-like responses. For four weeks, four groups of mice were simultaneously exposed to ambient concentrated PM2.5 or FA and/or dLAN or LD. Following exposure, mice underwent several behavioral assays and hippocampi were collected for qPCR and morphological analyses. Our results are generally comparable to previous PM2.5 and dLAN reports conducted on mice and implicate PM2.5 and dLAN as potential factors contributing to depression and anxiety. Short-term exposure to PM2.5 and dLAN upregulated neuroinflammatory cytokines and altered CA1 hippocampal structural changes, as well as provoked depressive-like responses (anhedonia). However, combined, PM2.5 and dLAN exposure did not have additive effects, as hypothesized, suggesting a ceiling effect of neuroinflammation may exist in response to multiple pollutants.
Address Department of Neuroscience, Behavioral Neuroendocrinology Group, The Ohio State University, Columbus, OH 43210, USA
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Series Volume Series Issue Edition
ISSN 0166-4328 ISBN Medium
Area Expedition Conference
Notes PMID:26235330 Approved no
Call Number LoNNe @ kyba @ Serial 1233
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Author Villamizar, N.; García-Alcazar, A.; Sánchez-Vázquez, F. J.
Title Effect of light spectrum and photoperiod on the growth, development and survival of European sea bass (Dicentrarchuslabrax) larvae Type Journal Article
Year 2009 Publication Abbreviated Journal
Volume (down) 292 Issue 1-2 Pages 80-86
Keywords animals; fish; light spectrum; photoperiod
Abstract This study investigates how the characteristics (spectrum and photoperiod) of artificial light affect European sea bass eggs and larvae from &#8722; 1 to 40 days post-hatching. Fertilised eggs and larvae were reared under five different light treatments: 12L:12D red light (LDR; half-peak bandwidth = 641–718 nm), 12L:12D blue light (LDB; half-peak bandwidth = 435–500 nm), 12L:12D broad-spectrum white light (LDW; 367 < &#955; < 1057 nm), 24L:0D broad-spectrum white light (LL) and 0L:24D (DD). The results showed that total length at day post-hatching 40 was significantly larger in larvae reared under LDB (15.4 ± 0.6 mm) and LL (15.2 ± 0.6 mm) than in larvae reared under LDR (11.7 ± 0.7 mm). Overall wet weight was highest under LDB (21.6 ± 2.02 mgr) and lowest in LDR larvae (13.6 ± 1.48 mgr). Yolk sac and oil globule absorption occurred more slowly in LDR and DD larvae, while LDB larvae developed their fin, teeth and swim bladder significantly earlier than the rest of the groups. DD larvae were unable to capture food and mortality was 100% by day post-hatching 18, while LDR larvae did not feed on rotifers, but fed on Artemia from day post-hatching 16 onwards. The best survival was obtained with the LL treatment, although significantly more problems with swim bladder development and lower jaw malformations were also identified in this group. In summary, these results highlight the key role of the light spectrum and photoperiod for European sea bass larvae, the best performance being achieved under the light conditions that best approached those of their natural aquatic environment (LDB). These findings should be considered when designing rearing protocols for larvae in aquaculture.
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Notes Approved no
Call Number LoNNe @ schroer @ Serial 1606
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Author Ruger, M.; Gordijn, M.C.M.; Beersma, D.G.M.; de Vries, B.; Daan, S.
Title Time-of-day-dependent effects of bright light exposure on human psychophysiology: comparison of daytime and nighttime exposure Type Journal Article
Year 2006 Publication American Journal of Physiology. Regulatory, Integrative and Comparative Physiology Abbreviated Journal Am J Physiol Regul Integr Comp Physiol
Volume (down) 290 Issue 5 Pages R1413-20
Keywords Human Health; Adult; Body Temperature/*physiology; Circadian Rhythm/*physiology; Fatigue/*physiopathology; Heart Rate/*physiology; Humans; Hydrocortisone/*blood; *Light; Sleep Stages/*physiology
Abstract Bright light can influence human psychophysiology instantaneously by inducing endocrine (suppression of melatonin, increasing cortisol levels), other physiological changes (enhancement of core body temperature), and psychological changes (reduction of sleepiness, increase of alertness). Its broad range of action is reflected in the wide field of applications, ranging from optimizing a work environment to treating depressed patients. For optimally applying bright light and understanding its mechanism, it is crucial to know whether its effects depend on the time of day. In this paper, we report the effects of bright light given at two different times of day on psychological and physiological parameters. Twenty-four subjects participated in two experiments (n = 12 each). All subjects were nonsmoking, healthy young males (18-30 yr). In both experiments, subjects were exposed to either bright light (5,000 lux) or dim light <10 lux (control condition) either between 12:00 P.M. and 4:00 P.M. (experiment A) or between midnight and 4:00 A.M. (experiment B). Hourly measurements included salivary cortisol concentrations, electrocardiogram, sleepiness (Karolinska Sleepiness Scale), fatigue, and energy ratings (Visual Analog Scale). Core body temperature was measured continuously throughout the experiments. Bright light had a time-dependent effect on heart rate and core body temperature; i.e., bright light exposure at night, but not in daytime, increased heart rate and enhanced core body temperature. It had no significant effect at all on cortisol. The effect of bright light on the psychological variables was time independent, since nighttime and daytime bright light reduced sleepiness and fatigue significantly and similarly.
Address Department of Chronobiology, University of Groningen, The Netherlands. Melanie.Rueger@med.nyu.edu
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Language English Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 0363-6119 ISBN Medium
Area Expedition Conference
Notes PMID:16373441 Approved no
Call Number LoNNe @ kagoburian @ Serial 801
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Author Owsley, C.
Title Impact of Cataract Surgery on Motor Vehicle Crash Involvement by Older Adults Type Journal Article
Year 2002 Publication Jama Abbreviated Journal Jama
Volume (down) 288 Issue 7 Pages 841
Keywords cataracts
Abstract We report the results of the Impact of Cataracts on Mobility (ICOM) project that was designed to address the question, for those older drivers who have cataract, what is the impact of cataract surgery on crash rate in the 4 years following surgery compared with those who have cataract who do not elect surgery? Strengths of this study design are the use of a comparison group of patients with cataract who do not undergo surgery followed prospectively over the same time period and the statistical adjustment for potential differences in the surgery and no surgery groups at baseline that could serve as confounders for the hypothesized effect. Using a randomized design would have been unethical since cataract surgery with intraocular lens implantation is an accepted and proven standard of care.
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
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ISSN 0098-7484 ISBN Medium
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Notes Approved no
Call Number IDA @ john @ Serial 170
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