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Author Anbalagan, M.; Dauchy, R.; Xiang, S.; Robling, A.; Blask, D.; Rowan, B.; Hill, S.
Title SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Type Journal Article
Year (down) 2019 Publication Journal of the Endocrine Society Abbreviated Journal
Volume 3 Issue Supplement_1 Pages
Keywords Animals
Abstract Breast cancer metastasis to bone is a major source of morbidity and mortality in women with advanced metastatic breast cancer. Morbidity from metastasis to bone is compounded by the fact that they cannot be surgically removed and can only be treated with chemotherapy and/or radiation therapy. Thus, there is critical need to develop new treatment strategies that kill bone metastatic tumors and reduce osteolytic lesions to improve patient quality of life and extend patient survival. Circadian rhythms are daily cycles of ~24 h that control many if not most physiologic processes and their disruption by exposure to light at night (LAN) or jet lag has been shown to be strongly associated with the development of cancer, particularly breast cancer. We have found that disruption of the anti-cancer circadian hormone melatonin (MLT) by light at night can significantly enhance the metastatic potential in breast cancer cells. Our work supports the report of the International Agency for Research on Cancer that shift work is a “probable human carcinogen” and highlights the association between exposure to light at night and invasive breast cancer. We recently reported that human breast tumor xenografts grown in athymic nude female rats housed in a photoperiod of 12h light at day: 12h dim light at night (dLAN, 0.2 lux – blocks the nighttime circadian MLT signal), display resistance to doxorubicin (Dox). More importantly, tumor growth and drug resistance could be blocked by the administration of Dox in circadian alignment with nocturnal MLT during dLAN. Our recent preliminary studies show that poorly invasive ERα positive MCF-7 breast cancer cells, when injected into the tibia (to mimic bone metastatic disease) of Foxn1nu athymic nude mice (which produce a strong circadian nighttime melatonin signal) housed in a dLAN photoperiod (suppressed nocturnal MLT production) developed full blown breast cancer tumors in bone (P<0.05) that are highly osteolytic (P<0.05). Moreover, patients with metastatic breast cancer are routinely treated with doxorubicin, which itself can promote bone damage. Our studies demonstrate that MLT slows the growth of metastatic breast cancer in bone but that the chrono-therapeutic use of doxorubicin in circadian alignment with melatonin in Foxn1nu mice with tibial breast tumors, reduced tumor growth in bone, reduced bone erosion, and promoted the formation of new bone. Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone.
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2472-1972 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2433
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Author Barros, R.; Medrano, F.; Norambuena, H.V.; Peredo, R.; Silva, R.; de Groote, F.; Schmitt, F.
Title Breeding Phenology, Distribution and Conservation Status of Markham's Storm-Petrel Oceanodroma markhami in the Atacama Desert Type Journal Article
Year (down) 2019 Publication Ardea Abbreviated Journal Ardea
Volume 107 Issue 1 Pages 75
Keywords Animals
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0373-2266 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2434
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Author Edensor, T.; Andrews, J.
Title Walking the creek: reconnecting place through light projection Type Journal Article
Year (down) 2019 Publication Geographical Research Abbreviated Journal Geographical Research
Volume in press Issue Pages
Keywords Society; Psychology
Abstract In this paper, we explore how a light projection sought to convey a range of qualities: conviviality, a sense of place, playfulness, defamiliarisation, and the affective and sensory capacities that were experienced through walking in the distinctive, liminal realm of Bendigo Creek in Victoria, Australia. The projection aspired to solicit a sensory and affective empathy that chimed with the experiences of an earlier event in which dozens of pedestrians were filmed walking in the creek. The projection contributed to a local campaign to reappraise the much‐maligned creek as a local public amenity. We discuss the productive potential of solitary and collective walking and, subsequently, the attributes of the projection in its static and mobile manifestation. In so doing, we suggest that publicly engaged, inclusive, creative practice can offer potent place‐making possibilities.
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1745-5863 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2435
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Author Ou, J.; Liu, X.; Liu, P.; Liu, X.
Title Evaluation of Luojia 1-01 nighttime light imagery for impervious surface detection: A comparison with NPP-VIIRS nighttime light data Type Journal Article
Year (down) 2019 Publication International Journal of Applied Earth Observation and Geoinformation Abbreviated Journal International Journal of Applied Earth Observation and Geoinformation
Volume 81 Issue Pages 1-12
Keywords Remote Sensing
Abstract Impervious surface detection is significant to urban dynamic monitoring and environment management. One of the most effective approaches to evaluating the impervious surface is the use of nighttime light imagery. However, little work on this subject was carried out with the new generation nighttime light data from Luojia 1-01 satellite, which has a finer spatial resolution than the predecessors such as the nightlight data from the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor on the Suomi National Polar-orbiting Partnership (NPP) Satellite. Therefore, this study conducted the first investigation of the capacity of Luojia 1-01 nighttime light data in detecting the extent and degree of impervious surfaces. Focusing on three cities of Beijing, Shanghai, and Guangzhou, several maps of the spatial extent of impervious surface areas were first extracted from two types of nighttime lights data (Luojia 1-01 and NPP-VIIRS data) by applying a dynamic threshold segmentation method. Meanwhile, a series of polynomial regression models were adopted to estimate the relation between imperiousness degree and light intensity. The results compared with the reference data derived from Landsat 8 Operational Land Imager (OLI) show that Luojia 1-01 data can produce a more precise map of the spatial extent of impervious surfaces than NPP-VIIRS data owing to the finer spatial resolution and the wider measurement range. Nevertheless, Luojia 1-01 data failed to provide reliable estimates of the imperviousness degree in comparison with NPP-VIIRS data as this nighttime light imagery with finer spatial resolution can better discriminate the surfaces that have the same imperviousness degree but are illuminated with different light intensities, consequently resulting in a weak correlation between imperviousness degree and light intensity. The over- and under-estimates of imperviousness degree suggested an increase in spatial resolution of nightlight imagery does not always improve the accuracy and reliability of nighttime light-based estimations. These study results confirmed that Luojia 1-01 nightlight imagery is a potential and promising data source for mapping the spatial extent of impervious surface areas, but difficult to accurately estimate the imperviousness degree. Future research may improve the accuracy of imperviousness degree estimation by integrating the Luojia 1-01 nightlight imagery with other useful data sources.
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0303-2434 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2436
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Author Wang, G., Wang, S., Zhang, L., Sun, F., Yan, F., & Yang, X.
Title A New Light Control Method with Charge Induction of Moving Target Type Journal Article
Year (down) 2019 Publication IEEE Sensors Journal Abbreviated Journal
Volume Issue Pages
Keywords Lighting; Instrumentation
Abstract Intelligent lamp control system has been widely studied all over the world because of its energy saving and social effect. In this paper, a new intelligent lamp control method based on charge induction for moving target is proposed. The detection model is established with the surface charge induction and verified by a luggage detection experiment. The intelligent lamp control system using the detection method is carried out. The performance of the system demonstrates that the proposed method can detect the moving target at any orientation whatever with or without occlusion and the detection distance can reach more than 3 m for the pedestrian.
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Notes Approved no
Call Number IDA @ intern @ Serial 2470
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