|   | 
Details
   web
Records
Author Duarte, C.; Quintanilla-Ahumada, D.; Anguita, C.; Manríquez, P.H.; Widdicombe, S.; Pulgar, J.; Silva-Rodriguez, E.A.; Miranda, C.; Manríquez, K.; Quijón, P.A.
Title Artificial light pollution at night (ALAN) disrupts the distribution and circadian rhythm of a sandy beach isopod Type Journal Article
Year (down) 2019 Publication Environmental Pollution Abbreviated Journal Environmental Pollution
Volume in press Issue Pages
Keywords Animals
Abstract Coastal habitats, in particular sandy beaches, are becoming increasingly exposed to artificial light pollution at night (ALAN). Yet, only a few studies have this far assessed the effects of ALAN on the species inhabiting these ecosystems. In this study we assessed the effects of ALAN on Tylos spinulosus, a prominent wrack-consumer isopod living in sandy beaches of north-central Chile. This species burrows in the sand during daylight and emerges at night to migrate down-shore, so we argue it can be used as a model species for the study of ALAN effects on coastal nocturnal species. We assessed whether ALAN alters the distribution and locomotor activity of this isopod using a light system placed in upper shore sediments close to the edge of the dunes, mimicking light intensities measured near public lighting. The response of the isopods was compared to control transects located farther away and not exposed to artificial light. In parallel, we measured the isopods’ locomotor activity in the laboratory using actographs that recorded their movement within mesocosms simulating the beach surface. Measurements in the field indicated a clear reduction in isopod abundance near the source of the light and a restriction of their tidal distribution range, as compared to control transects. Meanwhile, the laboratory experiments showed that in mesocosms exposed to ALAN, isopods exhibited reduced activity and a circadian rhythm that was altered and even lost after a few days. Such changes with respect to control mesocosms with a natural day/night cycle suggest that the changes observed in the field were directly related to a disruption in the locomotor activity of the isopods. All together these results provide causal evidence of negative ALAN effects on this species, and call for further research on other nocturnal sandy beach species that might become increasingly affected by ALAN.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0269-7491 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2228
Permanent link to this record
 

 
Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L.
Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
Year (down) 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol
Volume in press Issue Pages
Keywords Vision
Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.
Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-5761 ISBN Medium
Area Expedition Conference
Notes PMID:30778631 Approved no
Call Number GFZ @ kyba @ Serial 2229
Permanent link to this record
 

 
Author Youngstedt, S.D.; Elliott, J.A.; Kripke, D.F.
Title Human Circadian Phase-Response Curves for Exercise Type Journal Article
Year (down) 2019 Publication The Journal of Physiology Abbreviated Journal J Physiol
Volume in press Issue Pages
Keywords Human Health
Abstract KEY POINTS: Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of circadian rhythm phase shifts depending on the time of the zeigeber (time cue) stimulus is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity. 51 older and 48 young adults followed a circadian rhythms measurement protocol for up to 5.5 days, and performed 1 h of moderate treadmill exercise for 3 consecutive days at one of 8 times of day/night. Temporal changes in the phase of 6-sulphatoxymelatonin (aMT6s) were measured from evening onset, cosine acrophase, morning offset, and duration of excretion, establishing significant PRCs for aMT6 onset and acrophase with large phase delays from 7-10 PM and large phase advances at both 7 AM and 1-4 PM. Along with known synergism with bright light, the above PRCs with a second phase advance region (afternoon) could support both practical and clinical applications. ABSTRACT: Although bright light is regarded as the primary circadian zeitgeber, its limitations support exploring alternative zeitgebers. Exercise elicits significant circadian phase-shifting effects, but fundamental information regarding these effects is needed. The primary aim of this study was to establish phase-response curves (PRC) documenting the size and direction of phase shifts in relation to the circadian time of exercise. Aerobically fit older (n = 51, 59-75 y) and young adults (n = 48, 18-30 y) followed a 90-min laboratory ultra-short sleep wake cycle (60 min wake/30 min sleep) for up to 5 (1/2) days. At the same clock time on three consecutive days, each participant performed 60 min of moderate treadmill exercise (65-75% of heart rate reserve) at one of 8 times of day/night. To describe PRCs, phase shifts were measured for the cosine-fitted acrophase of urinary 6-sulphatoxymelatonin (aMT6s), as well as for the evening rise, morning decline, and change in duration of aMT6s excretion. Significant PRCs were found for aMT6s acrophase, onset and duration, with peak phase advances corresponding to clock times of 7 AM and 1PM-4PM, delays from 7 PM-10 PM, and minimal shifts around 4 PM and 2 AM. There were no significant age or sex differences. The amplitudes of the aMT6s onset and acrophase PRCs are comparable to expectations for bright light of equal duration. The phase advance to afternoon exercise and the exercise-induced PRC for change in aMT6s duration are novel findings. The results support further research exploring additive phase shifting effects of bright light and exercise and health benefits. This article is protected by copyright. All rights reserved.
Address Department of Psychiatry, University of California, San Diego, CA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-3751 ISBN Medium
Area Expedition Conference
Notes PMID:30784068 Approved no
Call Number GFZ @ kyba @ Serial 2230
Permanent link to this record
 

 
Author Clayson, Hollis
Title Illuminated Paris, Essays on Art and Lighting in the Belle Époque Type Book Whole
Year (down) 2019 Publication Abbreviated Journal
Volume Issue Pages
Keywords History; Society; Art
Abstract
Address Chicago
Corporate Author Thesis
Publisher University of Chicago Press Place of Publication Chicago Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 9780226593869 Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2231
Permanent link to this record
 

 
Author Canazei, M.; Pohl, W.; Weninger, J.; Bliem, H.; Weiss, E.M.; Koch, C.; Berger, A.; Firulovic, B.; Marth, C.
Title Effects of adjustable dynamic bedroom lighting in a maternity ward Type Journal Article
Year (down) 2019 Publication Journal of Environmental Psychology Abbreviated Journal Journal of Environmental Psychology
Volume 62 Issue Pages 59-66
Keywords Human Health
Abstract There exists initial evidence for beneficial daylight effects in hospital bedrooms. However, study results with automatically controlled dynamic bedroom lights were so far inconclusive. It can be hypothesized that inclusion of critically ill patients and unpleasant fixed bright light stimuli so far could have masked non-visual light effects on patient's sleep, mood and circadian physiology.

Therefore, a temporarily adjustable dynamic light was installed in double bedrooms in a maternity clinic. Although mothers were exposed to fixed morning bright light under dynamic light they were allowed to adjust light intensities the rest of the day. In contrast, light colours were automatically changed over 24 h and could not be altered. Double bedrooms with standard switchable light were utilized as active control condition.

A sample of 72 women, giving birth to healthy term babies, were randomly assigned to bedrooms with dynamic or standard light. Light conditions adjusted by mothers, sleep quality, mood and diurnal melatonin level, as well as physical activity levels of mothers and neonates, were recorded.

Mothers exposed themselves and their babies to higher daytime and lower evening light levels under dynamic light compared to standard light after the period of fixed morning bright light exposure had ended. Although no overall effects on maternal parameters could be observed under dynamic light, we could reveal an earlier daily onset of neonatal physical activity levels in these bedrooms.

To conclude, this study indicates that an adjustable dynamic light may substantially affect indoor light exposure in a maternity ward. Further studies are necessary to explore light effects on mothers and substantiate study results on neonates.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0272-4944 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2232
Permanent link to this record