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Author Yue, F.; Xia, K.; Wei, L.; Xing, L.; Wu, S.; Shi, Y.; Man, L.S.; Shui, G.; Xiang, X.; Russell, R.; Zhang, D.
Title Effects of constant light exposure on sphingolipidomics and progression of NASH in high‐fat‐fed rats Type Journal Article
Year (down) 2020 Publication Journal of Gastroenterology and Hepatology Abbreviated Journal J Gastroenterol Hepatol
Volume in press Issue Pages
Keywords Animals; apoptosis; ceramide; light pollution; non-alcoholic fatty liver disease; sphingolipids
Abstract BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms. METHODS: Thirty-two male SD rats were divided into 4 groups (n=8 each): 1) rats on a normal diet exposed to standard light-dark cycle (ND-LD); 2) rats on a normal diet exposed to constant light (ND-LL); 3) rats on a high fat diet exposed to standard light-dark cycle (HFD-LD); 4) and rats on a high fat diet exposed to constant light (HFD-LL). After 12 weeks treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides and lactosylceramides, sphingomyelins and sphingosine-1-phosphates in plasma and liver tissues. RESULTS: In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high-fat fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, inflammation and aggravated steatohepatitis. Compared to HFD-LD rats, HFD-LL had decreased plasma sphingosine-1-phosphate and elevated liver concentrations of total ceramides and specific ceramide species (ceramide d18:0/24:0, ceramide d18:1/22:0, ceramide d18:1/24:0 and ceramide d18:1/24:1), and which were associated with increased hepatocyte apoptosis. CONCLUSIONS: Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.
Address Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0815-9319 ISBN Medium
Area Expedition Conference
Notes PMID:32027419 Approved no
Call Number GFZ @ kyba @ Serial 2829
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Author Pan, Y.-R.; Song, J.-Y.; Fan, B.; Wang, Y.; Che, L.; Zhang, S.-M.; Chang, Y.-X.; He, C.; Li, G.-Y.
Title mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors Type Journal Article
Year (down) 2020 Publication Cell Communication and Signaling : CCS Abbreviated Journal Cell Commun Signal
Volume 18 Issue 1 Pages 27
Keywords Health; Aif; Parp-1; Parthanatos; Retinal neuroprotection; Sirt1; mTOR
Abstract BACKGROUND: Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cells remains unclear. The mammalian/mechanistic target of rapamycin (mTOR) and Poly (ADP-ribose) polymerase-1 (PARP-1) have become the primary targets for treating many neurodegenerative disorders. The aim of this study was to elucidate the mechanisms underlying light-induced photoreceptor cell death and whether the neuroprotective effects of mTOR and PARP-1 inhibition against death are mediated through apoptosis-inducing factor (AIF). METHODS: Propidium iodide (PI)/Hoechst staining, lentiviral-mediated short hairpin RNA (shRNA), Western blot analysis, cellular fraction separation, plasmid transient transfection, laser confocal microscopy, a mice model, electroretinography (ERG), and hematoxylin-eosin (H & E) staining were employed to explore the mechanisms by which rapamycin/3-Aminobenzamide (3AB) exert neuroprotective effects of mTOR/PARP-1 inhibition in light-injured retinas. RESULTS: A parthanatos-like death mechanism was evaluated in light-injured 661 W cells that are an immortalized photoreceptor-like cell line that exhibit cellular and biochemical feature characteristics of cone photoreceptor cells. The death process featured over-activation of PARP-1 and AIF nuclear translocation. Either PARP-1 or AIF knockdown played a significantly protective role for light-damaged photoreceptors. More importantly, crosstalk was observed between mTOR and PARP-1 signaling and mTOR could have regulated parthanatos via the intermediate factor sirtuin 1 (SIRT1). The parthanatos-like injury was also verified in vivo, wherein either PARP-1 or mTOR inhibition provided significant neuroprotection against light-induced injury, which is evinced by both structural and functional retinal analysis. Overall, these results elucidate the mTOR-regulated parthanatos death mechanism in light-injured photoreceptors/retinas and may facilitate the development of novel neuroprotective therapies for retinal degeneration diseases. CONCLUSIONS: Our results demonstrate that inhibition of the mTOR/PARP-1 axis exerts protective effects on photoreceptors against visible-light-induced parthanatos. These protective effects are conducted by regulating the downstream factors of AIF, while mTOR possibly interacts with PARP-1 via SIRT1 to regulate parthanatos. Video Abstract Schematic diagram of mTOR interacting with PARP-1 to regulate visible light-induced parthanatos. Increased ROS caused by light exposure penetrates the nuclear membrane and causes nuclear DNA strand breaks. PARP-1 detects DNA breaks and synthesizes PAR polymers to initiate the DNA repair system that consumes a large amount of cellular NAD+. Over-production of PAR polymers prompts the release of AIF from the mitochondria and translocation to the nucleus, which leads to parthanatos. Activated mTOR may interact with PARP-1 via SIRT1 to regulate visible light-induced parthanatos.
Address Department of Ophthalmology, Second Hospital of JiLin University, No.218 Zi-Qiang St, ChangChun, 130041, China. liguangyu@aliyun.com
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1478-811X ISBN Medium
Area Expedition Conference
Notes PMID:32066462 Approved no
Call Number GFZ @ kyba @ Serial 2830
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Author Letzkus, L.
Title Red Light at Night: A Feasibility Study in Hospitalized Patients Type Journal Article
Year (down) 2020 Publication MEDSURG Nursing Abbreviated Journal
Volume 29 Issue 1 Pages 38-42
Keywords Human Health
Abstract Light can be a noxious stimulus during hospitalization. The study evaluated use of a red night-light intervention for hospitalized adults. The red light was found to be a feasible intervention and well received by participants.
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2831
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Author Wu, Y.; Jiang, M.; Chang, Z.; Li, Y.; Shi, K.
Title Does China's Urban Development Satisfy Zipf's Law? A Multiscale Perspective from the NPP-VIIRS Nighttime Light Data Type Journal Article
Year (down) 2020 Publication International Journal of Environmental Research and Public Health Abbreviated Journal Int J Environ Res Public Health
Volume 17 Issue 4 Pages
Keywords Remote Sensing; China; Zipf's law; multiscale analysis; nighttime lights; urban development
Abstract Currently, whether the urban development in China satisfies Zipf's law across different scales is still unclear. Thus, this study attempted to explore whether China's urban development satisfies Zipf's law across different scales from the National Polar-Orbiting Partnership's Visible Infrared Imaging Radiometer Suite (NPP-VIIRS) nighttime light data. First, the NPP-VIIRS data were corrected. Then, based on the Zipf law model, the corrected NPP-VIIRS data were used to evaluate China's urban development at multiple scales. The results showed that the corrected NPP-VIIRS data could effectively reflect the state of urban development in China. Additionally, the Zipf index (q) values, which could express the degree of urban development, decreased from 2012 to 2018 overall in all provinces, prefectures, and counties. Since the value of q was relatively close to 1 with an R(2) value > 0.70, the development of the provinces and prefectures was close to the ideal Zipf's law state. In all counties, q > 1 with an R(2) value > 0.70, which showed that the primate county had a relatively stronger monopoly capacity. When the value of q < 1 with a continuous declination in the top 2000 counties, the top 250 prefectures, and the top 20 provinces in equilibrium, there was little difference in the scale of development at the multiscale level with an R(2) > 0.90. The results enriched our understanding of urban development in terms of Zipf's law and had valuable implications for relevant decision-makers and stakeholders.
Address Chongqing Engineering Research Centre for Remote Sensing Big Data Application, School of Geographical Sciences, Southwest University, Chongqing 400715, China
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1660-4601 ISBN Medium
Area Expedition Conference
Notes PMID:32102480 Approved no
Call Number GFZ @ kyba @ Serial 2832
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Author Qiang, Y.; Huang, Q.; Xu, J.
Title Observing Community Resilience from Space: Using Nighttime Lights to Model Economic Disturbance and Recovery Pattern in Natural Disaster Type Journal Article
Year (down) 2020 Publication Sustainable Cities and Society Abbreviated Journal Sustainable Cities and Society
Volume in press Issue Pages
Keywords Remote Sensing
Abstract A major challenge for measuring community resilience is the lack of empirical observation in disasters. As an effective tool for observing human activities on the earth surface, night-time light (NTL) remote sensing images can fill the gap of empirical data for measuring community resilience in natural disasters. This study introduces a quantitative framework to model the recovery pattern of economic activity in a natural disaster using the Defense Meteorological Satellite Program-Operational Linescan System (DMSP-OLS) images. The utility of the framework is demonstrated in a case study of Hurricane Katrina, which uncovered the great economic impact of Katrina and spatial variation of the disturbance and recovery pattern of economic activity. Environmental and socio-economic factors that potentially influence the economic recovery were explored in statistical analyses. Instead of a static and holistic index, the framework measures resilience as a dynamic process. The analysis results provide actionable information for prompting resilience in diverse communities and in different phases of a disaster. In addition to Hurricane Katrina, the resilience modeling framework is applicable for other disaster types. The introduced approaches and findings increase our understanding about the complexity of community resilience and provide support for developing resilient and sustainable communities.
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Language Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 2210-6707 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2833
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