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Author  |
Faraji, H.; MacLean, W.J. |
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Title |
CCD noise removal in digital images |
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Journal Article |
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2006 |
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IEEE Transactions on Image Processing |
Abbreviated Journal |
IEEE Trans. on Image Process. |
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15 |
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9 |
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2676-2685 |
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Remote Sensing |
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1057-7149 |
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LoNNe @ kagoburian @ |
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935 |
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Author |
Figueiro, M.G.; Rea, M.S.; Bullough, J.D. |
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Title |
Does architectural lighting contribute to breast cancer? |
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Journal Article |
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Year |
2006 |
Publication |
Journal of Carcinogenesis |
Abbreviated Journal |
J Carcinog |
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5 |
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20 |
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Human Health |
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OBJECTIVES: There is a growing interest in the role that light plays on nocturnal melatonin production and, perhaps thereby, the incidence of breast cancer in modern societies. The direct causal relationships in this logical chain have not, however, been fully established and the weakest link is an inability to quantitatively specify architectural lighting as a stimulus for the circadian system. The purpose of the present paper is to draw attention to this weakness. DATA SOURCES AND EXTRACTION: We reviewed the literature on the relationship between melatonin, light at night, and cancer risk in humans and tumor growth in animals. More specifically, we focused on the impact of light on nocturnal melatonin suppression in humans and on the applicability of these data to women in real-life situations. Photometric measurement data from the lighted environment of women at work and at home is also reported. DATA SYNTHESIS: The literature review and measurement data demonstrate that more quantitative knowledge is needed about circadian light exposures actually experienced by women and girls in modern societies. CONCLUSION: Without such quantitative knowledge, limited insights can be gained about the causal relationship between melatonin and the etiology of breast cancer from epidemiological studies and from parametric studies using animal models. |
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Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street Troy, NY 12180 USA. figuem@rpi.edu |
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1477-3163 |
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PMID:16901343; PMCID:PMC1557490 |
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LoNNe @ kagoburian @ |
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746 |
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Filipski, E.; Li, X.M.; Levi, F. |
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Title |
Disruption of circadian coordination and malignant growth |
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Journal Article |
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Year |
2006 |
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Cancer Causes & Control : CCC |
Abbreviated Journal |
Cancer Causes Control |
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17 |
Issue |
4 |
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509-514 |
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Human Health; Animals; Biological Clocks; Body Temperature; Cell Cycle Proteins; Cell Line, Tumor; Chronobiology Disorders/*complications/physiopathology; Circadian Rhythm; Corticosterone/blood; DNA-Binding Proteins/metabolism; Jet Lag Syndrome/complications/physiopathology; Lymphocyte Count; Mice; Neoplasm Transplantation; Nuclear Proteins/metabolism; Nuclear Receptor Subfamily 1, Group D, Member 1; Osteosarcoma/*pathology/physiopathology; Pancreatic Neoplasms/*pathology/physiopathology; Period Circadian Proteins; Receptors, Cytoplasmic and Nuclear/metabolism; Suprachiasmatic Nucleus/physiopathology; Transcription Factors/metabolism |
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Altered circadian rhythms predicted for poor survival in patients with metastatic colorectal or breast cancer. An increased incidence of cancers has been reported in flying attendants and in women working predominantly at night. To explore the contribution of circadian structure to tumor growth we ablated the 24-h rest-activity cycle and markedly altered the rhythms in body temperature, serum corticosterone and lymphocyte count in mice by complete stereotaxic destruction of the suprachiasmatic nuclei (SCN) or by subjecting the mice to experimental chronic jet-lag. Such disruption of circadian coordination significantly accelerated malignant growth in two transplantable tumor models, Glasgow osteosarcoma and Pancreatic adenocarcinoma. The mRNA expression of clock genes per2 and reverb-alpha in controls displayed significant circadian rhythms in the liver (Cosinor, p=0.006 and p=0.003, respectively) and in the tumor (p=0.04 and p<0.001, respectively). Both rhythms were suppressed in the liver and in the tumor of jet lagged mice. This functional disturbance of molecular clock resulted in down regulation of p53 and overexpression of c-Myc, two effects which may favor cancer growth. CONCLUSIONS: These results indicate that circadian system could play an important role in malignant growth control. This should be taken into consideration in cancer prevention and therapy. |
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INSERM E 354 Cancer Chronotherapeutics, Hopital Paul Brousse, Villejuif, France. filipski@vjf.inserm.fr |
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0957-5243 |
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PMID:16596304 |
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LoNNe @ kagoburian @ |
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748 |
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Author |
Fisher, N.A. |
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Title |
Reclaiming the „Dark Sky“. |
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2006 |
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Electrical Contracting Products |
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9 |
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6 |
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30–31 |
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Energy; Lighting |
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LoNNe @ kagoburian @ |
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1036 |
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Author |
Fouquet, R.; Pearson, P.J. |
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Title |
Seven centuries of energy services: The price and use of light in the United Kingdom (1300-2000) |
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Journal Article |
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2006 |
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Energy Journal |
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27 |
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139-177 |
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Energy; Economics |
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Before the mid-eighteenth century, most people lived in near-complete
darkness except in the presence of sunlight and moonlight. Since then, the provision
of artificial light has been revolutionised by a series of innovations in appliances,
fuels, infrastructures and institutions that have enabled the growing demands of
economic development for artificial light to be met at dramatically lower costs:
by the year 2000, while United Kingdom GDP per capita was 15 times its 1800
value, lighting services cost less than one three thousandth of their 1800 value,
per capita use was 6,500 times greater and total lighting consumption was 25,000
times higher than in 1800. The economic history of light shows how focussing on
developments in energy service provision rather than simply on energy use and
prices can reveal the ‘true’ declines in costs, enhanced levels of consumption
and welfare gains that have been achieved. While emphasising the value of past
experience, the paper also warns against the dangers of over-reliance on past
trends for the long-run forecasting of energy consumption given the potential for the
introduction of new technologies and fuels, and for rebound and saturation effects. |
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LoNNe @ christopher.kyba @ |
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441 |
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