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Author Haus, E.; Smolensky, M. url  doi
openurl 
  Title Biological clocks and shift work: circadian dysregulation and potential long-term effects Type Journal Article
  Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 17 Issue 4 Pages 489-500  
  Keywords Human Health; Adaptation, Physiological; Animals; Biological Clocks; Cardiovascular Abnormalities/etiology; Chronobiology Disorders/*complications/physiopathology; Chronobiology Phenomena; Humans; Neoplasms/etiology; Occupational Diseases/*etiology; Risk Factors; Suprachiasmatic Nucleus/physiopathology; *Work Schedule Tolerance  
  Abstract Long-term epidemiologic studies on large numbers of night and rotating shift workers have suggested an increase in the incidence of breast and colon cancer in these populations. These studies suffer from poor definition and quantification of the work schedules of the exposed subjects. Against this background, the pathophysiology of phase shift and phase adaptation is reviewed. A phase shift as experienced in night and rotating shift work involves desynchronization at the molecular level in the circadian oscillators in the central nervous tissue and in most peripheral tissues of the body. There is a change in the coordination between oscillators with transient loss of control by the master-oscillator (the Suprachiasmatic Nucleus, SCN) in the hypothalamus. The implications of the pathophysiology of phase shift are discussed for long-term health effects and for the design of ergonomic work schedules minimizing the adverse health effects upon the worker.  
  Address Department of Laboratory Medicine & Pathology, University of Minnesota, Health Partners Medical Group, Regions Hospital, St. Paul, Minnesota 55101, USA. Erhard.X.Haus@Healthpartners.com  
  Corporate Author Thesis  
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  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16596302 Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 760  
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Author IDA openurl 
  Title Dark-Sky Park Program Type Journal Article
  Year 2006 Publication edited by International Dark-Sky Association Abbreviated Journal  
  Volume Issue Pages 11  
  Keywords Skyglow  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 763  
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Author Jasser, S.A.; Blask, D.E.; Brainard, G.C. url  doi
openurl 
  Title Light during darkness and cancer: relationships in circadian photoreception and tumor biology Type Journal Article
  Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 17 Issue 4 Pages 515-523  
  Keywords Human Health; Animals; *Circadian Rhythm; *Darkness; Humans; *Light; Light Signal Transduction; Melatonin/physiology/secretion; Neoplasms/etiology/pathology/*physiopathology; Suprachiasmatic Nucleus/physiology  
  Abstract The relationship between circadian phototransduction and circadian-regulated processes is poorly understood. Melatonin, commonly a circadian phase marker, may play a direct role in a myriad of physiologic processes. The circadian rhythm for pineal melatonin secretion is regulated by the hypothalamic suprachiasmatic nucleus (SCN). Its neural source of light input is a unique subset of intrinsically photosensitive retinal ganglion cells expressing melanopsin, the primary circadian photopigment in rodents and primates. Action spectra of melatonin suppression by light have shown that light in the 446-477 nm range, distinct from the visual system's peak sensitivity, is optimal for stimulating the human circadian system. Breast cancer is the oncological disease entity whose relationship to circadian rhythm fluctuations has perhaps been most extensively studied. Empirical data has increasingly supported the hypothesis that higher risk of breast cancer in industrialized countries is partly due to increased exposure to light at night. Studies of tumor biology implicate melatonin as a potential mediator of this effect. Yet, causality between lifestyle factors and circadian tumor biology remains elusive and likely reflects significant variability with physiologic context. Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time.  
  Address Department of Neurology, Light Research Program, Thomas Jefferson University, 1025 Walnut Street, Suite 507, Philadelphia, PA 19107, USA. samar.jasser@jefferson.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16596305 Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 766  
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Author Moser, M.; Schaumberger, K.; Schernhammer, E.; Stevens, R.G. url  doi
openurl 
  Title Cancer and rhythm Type Journal Article
  Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 17 Issue 4 Pages 483-487  
  Keywords Human Health; Animals; Breast Neoplasms/etiology/physiopathology/prevention & control; Chronobiology Phenomena; Chronotherapy; *Circadian Rhythm; Humans; Life Style; Melatonin/metabolism; Neoplasms/etiology/*physiopathology/prevention & control/therapy; Risk Factors  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16596301 Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 786  
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Author Reiter, R.J.; Gultekin, F.; Manchester, L.C.; Tan, D.-X. url  doi
openurl 
  Title Light pollution, melatonin suppression and cancer growth Type Journal Article
  Year 2006 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume 40 Issue 4 Pages 357-358  
  Keywords Human Health; Animals; Cell Division; Cell Line, Tumor; Humans; *Light; Melatonin/*antagonists & inhibitors; Neoplasms/*pathology; Rats  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16635025 Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 798  
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