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Author Reiter, R.J.; Gultekin, F.; Manchester, L.C.; Tan, D.-X.
Title Light pollution, melatonin suppression and cancer growth Type Journal Article
Year 2006 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res
Volume 40 Issue 4 Pages 357-358
Keywords Human Health; Animals; Cell Division; Cell Line, Tumor; Humans; *Light; Melatonin/*antagonists & inhibitors; Neoplasms/*pathology; Rats
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Language English Summary Language Original Title
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ISSN (up) 0742-3098 ISBN Medium
Area Expedition Conference
Notes PMID:16635025 Approved no
Call Number LoNNe @ kagoburian @ Serial 798
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Author Curtis, A.M.; FitzGerald, G.A.
Title Central and peripheral clocks in cardiovascular and metabolic function Type Journal Article
Year 2006 Publication Annals of Medicine Abbreviated Journal Ann Med
Volume 38 Issue 8 Pages 552-559
Keywords Human Health
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ISSN (up) 0785-3890 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kagoburian @ Serial 730
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Author Doll, C.N.H.; Muller, J.-P.; Morley, J.G.
Title Mapping regional economic activity from night-time light satellite imagery Type Journal Article
Year 2006 Publication Ecological Economics Abbreviated Journal Ecological Economics
Volume 57 Issue 1 Pages 75-92
Keywords Night-time light satellite imagery; Economic activity; Geographic information; Mapping; Scale
Abstract The recognition that the elements of the ‘anthropocene’ play a critical role in global change processes means that datasets describing elements of the socio-economic environment are becoming increasingly more desirable. The ability to present these data in a gridded format as opposed to the traditionally reported administrative units is advantageous for incorporation with other environmental datasets. Night-time light remote sensing data has been shown to correlate with national-level figures of Gross Domestic Product (GDP). Night-time radiance data is analysed here along with regional economic productivity data for 11 European Union countries along with the United States at a number of sub-national levels. Night-time light imagery was found to correlate with Gross Regional Product (GRP) across a range of spatial scales. Maps of economic activity at 5 km resolution were produced based on the derived relationships. To produce these maps, certain areas had to be excluded due to their anomalously high levels of economic activity for the amount of total radiance present. These areas were treated separately from other areas in the map. These results provide the first detailed examination of night-time light characteristics with respect to local economic activity and highlight issues, which should be considered when undertaking such analysis.
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ISSN (up) 0921-8009 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 124
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Author Cajochen, C.; Jud, C.; Munch, M.; Kobialka, S.; Wirz-Justice, A.; Albrecht, U.
Title Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans Type Journal Article
Year 2006 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci
Volume 23 Issue 4 Pages 1082-1086
Keywords Human Health; Adult; Color; Darkness; Dose-Response Relationship, Radiation; Female; Gene Expression/*radiation effects; Humans; *Light; Male; Melatonin/metabolism; Mucous Membrane/metabolism/radiation effects; Nuclear Proteins/genetics/*metabolism; Period Circadian Proteins; Transcription Factors/genetics/*metabolism
Abstract We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders.
Address Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH-4025 Basel, Switzerland. christian.cajochen@unibas.ch
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Language English Summary Language Original Title
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ISSN (up) 0953-816X ISBN Medium
Area Expedition Conference
Notes PMID:16519674 Approved no
Call Number LoNNe @ kagoburian @ Serial 727
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Author Bullough, J.D.; Rea, M.S.; Figueiro, M.G.
Title Of mice and women: light as a circadian stimulus in breast cancer research Type Journal Article
Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control
Volume 17 Issue 4 Pages 375-383
Keywords Human Health; Animals; Breast Neoplasms/*physiopathology; *Circadian Rhythm; *Disease Models, Animal; Female; Humans; *Light; Light Signal Transduction; Mammary Neoplasms, Animal/*physiopathology; Melatonin/metabolism; Mice; Muridae/metabolism
Abstract OBJECTIVE: Nocturnal rodents are frequently used as models in human breast cancer research, but these species have very different visual and circadian systems and, therefore, very different responses to optical radiation or, informally, light. Because of the impact of light on the circadian system and because recent evidence suggests that cancer risk might be related to circadian disruption, it is becoming increasingly clear that optical radiation must be properly characterized for both nocturnal rodents and diurnal humans to make significant progress in unraveling links between circadian disruption and breast cancer. In this paper, we propose a quantitative framework for comparing radiometric and photometric quantities in human and rodent studies. METHODS: We reviewed published research on light as a circadian stimulus for humans and rodents. Both suppression of nocturnal melatonin and phase shifting were examined as outcome measures for the circadian system. RESULTS: The data were used to develop quantitative comparisons regarding the absolute and spectral sensitivity for the circadian systems of humans and nocturnal rodents. CONCLUSIONS: Two models of circadian phototransduction, for mouse and humans, have been published providing spectral sensitivities for these two species. Despite some methodological variations among the studies reviewed, the circadian systems of nocturnal rodents are approximately 10,000 times more sensitive to optical radiation than that of humans. Circadian effectiveness of different sources for both humans and nocturnal rodents are offered together with a scale relating their absolute sensitivities. Instruments calibrated in terms of conventional photometric units (e.g., lux) will not accurately characterize the circadian stimulus for either humans or rodents.
Address Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA. bulloj@rpi.edu
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Language English Summary Language Original Title
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ISSN (up) 0957-5243 ISBN Medium
Area Expedition Conference
Notes PMID:16596289 Approved no
Call Number LoNNe @ kagoburian @ Serial 726
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