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Author Bullough, J.D.; Rea, M.S.; Figueiro, M.G.
Title Of mice and women: light as a circadian stimulus in breast cancer research Type Journal Article
Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control
Volume 17 Issue 4 Pages 375-383
Keywords (up) Human Health; Animals; Breast Neoplasms/*physiopathology; *Circadian Rhythm; *Disease Models, Animal; Female; Humans; *Light; Light Signal Transduction; Mammary Neoplasms, Animal/*physiopathology; Melatonin/metabolism; Mice; Muridae/metabolism
Abstract OBJECTIVE: Nocturnal rodents are frequently used as models in human breast cancer research, but these species have very different visual and circadian systems and, therefore, very different responses to optical radiation or, informally, light. Because of the impact of light on the circadian system and because recent evidence suggests that cancer risk might be related to circadian disruption, it is becoming increasingly clear that optical radiation must be properly characterized for both nocturnal rodents and diurnal humans to make significant progress in unraveling links between circadian disruption and breast cancer. In this paper, we propose a quantitative framework for comparing radiometric and photometric quantities in human and rodent studies. METHODS: We reviewed published research on light as a circadian stimulus for humans and rodents. Both suppression of nocturnal melatonin and phase shifting were examined as outcome measures for the circadian system. RESULTS: The data were used to develop quantitative comparisons regarding the absolute and spectral sensitivity for the circadian systems of humans and nocturnal rodents. CONCLUSIONS: Two models of circadian phototransduction, for mouse and humans, have been published providing spectral sensitivities for these two species. Despite some methodological variations among the studies reviewed, the circadian systems of nocturnal rodents are approximately 10,000 times more sensitive to optical radiation than that of humans. Circadian effectiveness of different sources for both humans and nocturnal rodents are offered together with a scale relating their absolute sensitivities. Instruments calibrated in terms of conventional photometric units (e.g., lux) will not accurately characterize the circadian stimulus for either humans or rodents.
Address Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA. bulloj@rpi.edu
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0957-5243 ISBN Medium
Area Expedition Conference
Notes PMID:16596289 Approved no
Call Number LoNNe @ kagoburian @ Serial 726
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Author Moser, M.; Schaumberger, K.; Schernhammer, E.; Stevens, R.G.
Title Cancer and rhythm Type Journal Article
Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control
Volume 17 Issue 4 Pages 483-487
Keywords (up) Human Health; Animals; Breast Neoplasms/etiology/physiopathology/prevention & control; Chronobiology Phenomena; Chronotherapy; *Circadian Rhythm; Humans; Life Style; Melatonin/metabolism; Neoplasms/etiology/*physiopathology/prevention & control/therapy; Risk Factors
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0957-5243 ISBN Medium
Area Expedition Conference
Notes PMID:16596301 Approved no
Call Number LoNNe @ kagoburian @ Serial 786
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Author Reiter, R.J.; Gultekin, F.; Manchester, L.C.; Tan, D.-X.
Title Light pollution, melatonin suppression and cancer growth Type Journal Article
Year 2006 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res
Volume 40 Issue 4 Pages 357-358
Keywords (up) Human Health; Animals; Cell Division; Cell Line, Tumor; Humans; *Light; Melatonin/*antagonists & inhibitors; Neoplasms/*pathology; Rats
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-3098 ISBN Medium
Area Expedition Conference
Notes PMID:16635025 Approved no
Call Number LoNNe @ kagoburian @ Serial 798
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Author Srinivasan, V.; Smits, M.; Spence, W.; Lowe, A.D.; Kayumov, L.; Pandi-Perumal, S.R.; Parry, B.; Cardinali, D.P.
Title Melatonin in mood disorders Type Journal Article
Year 2006 Publication The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry Abbreviated Journal World J Biol Psychiatry
Volume 7 Issue 3 Pages 138-151
Keywords (up) Human Health; Antidepressive Agents/therapeutic use; Biological Markers/blood; Bipolar Disorder/diagnosis/drug therapy/*physiopathology; Circadian Rhythm/drug effects/physiology; Depressive Disorder/diagnosis/drug therapy/*physiopathology; Depressive Disorder, Major/diagnosis/drug therapy/physiopathology; Humans; Melatonin/*blood/therapeutic use; Phototherapy; Seasonal Affective Disorder/diagnosis/physiopathology; Sleep Disorders, Circadian Rhythm/diagnosis/drug therapy/physiopathology; Treatment Outcome
Abstract The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the existence of disturbed sleep-wake and core body temperature rhythms, all suggest that dysfunction of the circadian time keeping system may underlie the pathophysiology of depression. As a rhythm-regulating factor, the study of melatonin in various depressive illnesses has gained attention. Melatonin can be both a 'state marker' and a 'trait marker' of mood disorders. Measurement of melatonin either in saliva or plasma, or of its main metabolite 6-sulfatoxymelatonin in urine, have documented significant alterations in melatonin secretion in depressive patients during the acute phase of illness. Not only the levels but also the timing of melatonin secretion is altered in bipolar affective disorder and in patients with seasonal affective disorder (SAD). A phase delay of melatonin secretion takes place in SAD, as well as changes in the onset, duration and offset of melatonin secretion. Bright light treatment, that suppresses melatonin production, is effective in treating bipolar affective disorder and SAD, winter type. This review discusses the role of melatonin in the pathophysiology of bipolar disorder and SAD.
Address Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1562-2975 ISBN Medium
Area Expedition Conference
Notes PMID:16861139 Approved no
Call Number LoNNe @ kagoburian @ Serial 816
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Author Li, Q.F.; Yang, G.X.; Yu, L.H.; Zhang, H.
Title A survey of the luminance distribution in the nocturnal environment in Shanghai urban areas and the control of luminance of floodlit buildings Type Journal Article
Year 2006 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology
Volume 38 Issue 3 Pages 185-189
Keywords (up) Lighting
Abstract A survey of the luminance distribution of the nocturnal environment in Shanghai urban areas, which included 11 locations and 16 buildings, was made. The 11 locations could be categorized as commercial, administration, leisure or residential. The average environmental luminance of these was recorded. The authors identified the effects of excessive exterior lighting. The luminance was measured and subjective appraisals made of 16 buildings. The writers have developed an empirical formula for arriving at the brightness level rating for floodlit buildings and recommended corresponding working ranges of luminance.
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Language Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 1477-1535 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2715
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