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Author Filipski, E.; Li, X.M.; Levi, F. url  doi
openurl 
  Title (down) Disruption of circadian coordination and malignant growth Type Journal Article
  Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 17 Issue 4 Pages 509-514  
  Keywords Human Health; Animals; Biological Clocks; Body Temperature; Cell Cycle Proteins; Cell Line, Tumor; Chronobiology Disorders/*complications/physiopathology; Circadian Rhythm; Corticosterone/blood; DNA-Binding Proteins/metabolism; Jet Lag Syndrome/complications/physiopathology; Lymphocyte Count; Mice; Neoplasm Transplantation; Nuclear Proteins/metabolism; Nuclear Receptor Subfamily 1, Group D, Member 1; Osteosarcoma/*pathology/physiopathology; Pancreatic Neoplasms/*pathology/physiopathology; Period Circadian Proteins; Receptors, Cytoplasmic and Nuclear/metabolism; Suprachiasmatic Nucleus/physiopathology; Transcription Factors/metabolism  
  Abstract Altered circadian rhythms predicted for poor survival in patients with metastatic colorectal or breast cancer. An increased incidence of cancers has been reported in flying attendants and in women working predominantly at night. To explore the contribution of circadian structure to tumor growth we ablated the 24-h rest-activity cycle and markedly altered the rhythms in body temperature, serum corticosterone and lymphocyte count in mice by complete stereotaxic destruction of the suprachiasmatic nuclei (SCN) or by subjecting the mice to experimental chronic jet-lag. Such disruption of circadian coordination significantly accelerated malignant growth in two transplantable tumor models, Glasgow osteosarcoma and Pancreatic adenocarcinoma. The mRNA expression of clock genes per2 and reverb-alpha in controls displayed significant circadian rhythms in the liver (Cosinor, p=0.006 and p=0.003, respectively) and in the tumor (p=0.04 and p<0.001, respectively). Both rhythms were suppressed in the liver and in the tumor of jet lagged mice. This functional disturbance of molecular clock resulted in down regulation of p53 and overexpression of c-Myc, two effects which may favor cancer growth. CONCLUSIONS: These results indicate that circadian system could play an important role in malignant growth control. This should be taken into consideration in cancer prevention and therapy.  
  Address INSERM E 354 Cancer Chronotherapeutics, Hopital Paul Brousse, Villejuif, France. filipski@vjf.inserm.fr  
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  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16596304 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 748  
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Author Powe, N.A; Willis, K.G.; Garrod, G.D. openurl 
  Title (down) Difficulties in Valuing Street Light Improvement: Trust, Surprise and Bound Effects Type Journal Article
  Year 2006 Publication Applied Economics Abbreviated Journal  
  Volume 38 Issue 4 Pages 371–381  
  Keywords Economics  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 1055  
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Author Coffin, D. url  openurl
  Title (down) Dave Coffin&#347; DCRAW. Type Journal Article
  Year 2006 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords Remote Sensing  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 916  
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Author IDA openurl 
  Title (down) Dark-Sky Park Program Type Journal Article
  Year 2006 Publication edited by International Dark-Sky Association Abbreviated Journal  
  Volume Issue Pages 11  
  Keywords Skyglow  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 763  
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Author Johnsen, S.; Kelber, A.; Warrant, E.; Sweeney, A.M.; Widder, E.A.; Lee, R.L.J.; Hernandez-Andres, J. url  doi
openurl 
  Title (down) Crepuscular and nocturnal illumination and its effects on color perception by the nocturnal hawkmoth Deilephila elpenor Type Journal Article
  Year 2006 Publication The Journal of Experimental Biology Abbreviated Journal J Exp Biol  
  Volume 209 Issue Pt 5 Pages 789-800  
  Keywords Animals; Color Perception/*physiology; Ecosystem; *Light; Moths/*physiology  
  Abstract Recent studies have shown that certain nocturnal insect and vertebrate species have true color vision under nocturnal illumination. Thus, their vision is potentially affected by changes in the spectral quality of twilight and nocturnal illumination, due to the presence or absence of the moon, artificial light pollution and other factors. We investigated this in the following manner. First we measured the spectral irradiance (from 300 to 700 nm) during the day, sunset, twilight, full moon, new moon, and in the presence of high levels of light pollution. The spectra were then converted to both human-based chromaticities and to relative quantum catches for the nocturnal hawkmoth Deilephila elpenor, which has color vision. The reflectance spectra of various flowers and leaves and the red hindwings of D. elpenor were also converted to chromaticities and relative quantum catches. Finally, the achromatic and chromatic contrasts (with and without von Kries color constancy) of the flowers and hindwings against a leaf background were determined under the various lighting environments. The twilight and nocturnal illuminants were substantially different from each other, resulting in significantly different contrasts. The addition of von Kries color constancy significantly reduced the effect of changing illuminants on chromatic contrast, suggesting that, even in this light-limited environment, the ability of color vision to provide reliable signals under changing illuminants may offset the concurrent threefold decrease in sensitivity and spatial resolution. Given this, color vision may be more common in crepuscular and nocturnal species than previously considered.  
  Address Biology Department, Duke University, Durham, NC 27708, USA. sjohnsen@duke.edu  
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  ISSN 0022-0949 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16481568 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 604  
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