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Author Johns, L.E.; Jones, M.E.; Schoemaker, M.J.; McFadden, E.; Ashworth, A.; Swerdlow, A.J. url  doi
openurl 
  Title Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal (up) Br J Cancer  
  Volume 118 Issue Pages 600-606  
  Keywords Human Health  
  Abstract BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors. RESULTS: There was no association between LAN level and breast cancer risk overall (highest compared with lowest LAN level at recruitment: HR=1.01, 95% confidence interval (CI): 0.88-1.15), or for invasive (HR=0.98, 95% CI: 0.85-1.13) or in situ (HR=0.96, 95% CI: 0.83-1.11) breast cancer, or oestrogen-receptor (ER) positive (HR=0.98, 95% CI: 0.84-1.14); or negative (HR=1.16, 95% CI: 0.82-1.65) tumours separately. The findings did not differ by menopausal status. Adjusting for sleep duration, sleeping at unusual times (non-peak sleep) and history of night work did not affect the results. Night waking with exposure to light, occurring around age 20, was associated with a reduced risk of premenopausal breast cancer (HR for breast cancer overall=0.74, 95% CI: 0.55-0.99; HR for ER-positive breast cancer=0.69, 95% CI: 0.49-0.97). CONCLUSIONS: In this prospective cohort analysis of LAN, there was no evidence that LAN exposure increased the risk of subsequent breast cancer, although the suggestion of a lower breast cancer risk in pre-menopausal women with a history of night waking in their twenties may warrant further investigation.British Journal of Cancer advance online publication, 23 January 2018; doi:10.1038/bjc.2017.359 www.bjcancer.com.  
  Address Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29360812 Approved no  
  Call Number LoNNe @ kyba @ Serial 1803  
Permanent link to this record
 

 
Author Mortazavi, S.M.J. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal (up) Br J Cancer  
  Volume 118 Issue 11 Pages 1536  
  Keywords Commentary  
  Abstract  
  Address Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran. S.M.Javad.Mortazavi@fccc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29769746 Approved no  
  Call Number GFZ @ kyba @ Serial 1911  
Permanent link to this record
 

 
Author Stevens, R.G. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal (up) Br J Cancer  
  Volume in press Issue Pages  
  Keywords Commentary; Human Health  
  Abstract  
  Address University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30283145 Approved no  
  Call Number GFZ @ kyba @ Serial 2035  
Permanent link to this record
 

 
Author Kyba, C.C.M.; Spitschan, M. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal (up) Br J Cancer  
  Volume in press Issue Pages  
  Keywords Human Health; Commentary  
  Abstract  
  Address Department of Experimental Psychology, University of Oxford, Oxford, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30584260 Approved no  
  Call Number GFZ @ kyba @ Serial 2145  
Permanent link to this record
 

 
Author Cai, W.; Yue, J.; Dai, Q.; Hao, L.; Lin, Y.; Shi, W.; Huang, Y.; Wei, M. url  doi
openurl 
  Title The impact of room surface reflectance on corneal illuminance and rule-of-thumb equations for circadian lighting design Type Journal Article
  Year 2018 Publication Building and Environment Abbreviated Journal (up) Building and Environment  
  Volume 141 Issue Pages 288-297  
  Keywords Lighting  
  Abstract Recently, corneal illuminance attracts much attention because it is closely related to important functions of indoor lighting. Especially, applying circadian light in the built environment places a challenging requirement on indirect corneal illuminance. In this work, rule-of-thumb equations are proposed to guide circadian lighting design: (i) for artificial lighting, Ecor,avg (i) = (Φ/C1) · ρ/(1−ρ′), where Ecor,avg (i) is the average indirect corneal illuminance at standing or sitting positions, Φ is the initial flux from luminaires, C1 is a constant comparable to the total room surface area, ρ is the reflectance of the surface where the first reflection occurs, and ρ′ is the area-weighted average of surface reflectance; and (ii) for daylighting, Ecor,avg (i) = C2 · WWR · ρ/(1−ρ′), where C2 is a constant, and WWR represents the window-to-wall ratio.

The equations above are validated by comparing against numerical simulation data obtained with the Radiance software. For artificial lighting simulation, various combinations of room surface reflectance, initial light distribution, and WWR are investigated; and for daylighting simulation, different combinations of surface reflectance, WWR, and geographic location are analyzed. The good fits to simulation data indicate that the proposed simple equations can provide reasonably accurate results for quick feedback at the field. It is also demonstrated that room surface reflectance has a dominant impact on indirect corneal illuminance. The approach of improving surface reflectance is more favorable than increasing luminaire flux or expanding window area, and therefore should be the recommended approach to achieve quality and efficient circadian lighting.
 
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0360-1323 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 1929  
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