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Author Patel, J.S.; Radetsky, L.; Rea, M.S. url  doi
openurl 
  Title The Value of Red Light at Night for Increasing Basil Yield Type Journal Article
  Year 2018 Publication Canadian Journal of Plant Science Abbreviated Journal (up) Can. J. Plant Sci.  
  Volume 98 Issue 6 Pages 1321-1330  
  Keywords Plants  
  Abstract Sweet basil (<i>Ocimum basilicum L.</i>) is primarily used for culinary purposes, but it is also used in the fragrance and medicinal industries. In the last few years, global sweet basil production has been significantly impacted by downy mildew caused by <i>Peronospora belbahrii</i>. Nighttime exposure to red light has been shown to inhibit sporulation of <i>P. belbahrii</i>. The objective of this study was to determine if nighttime exposure to red light from light-emitting diodes (LEDs; λ<sub>max</sub> = 625 nm) could increase plant growth (plant height and leaf size) and yield (number and weight of leaves) in basil plants. In two sets of greenhouse experiments, red light was applied at a photosynthetic photon flux density (PPFD) of 60 µmol m<sup>-2</sup> s<sup>-1</sup> during the otherwise dark night for 10 hours (from 20:00 to 06:00). The results demonstrate that exposure to red light at night can increase the number of basil leaves per plant, plant height, leaf size (length and width), and leaf fresh and dry weight, compared to plants in darkness at night. The addition of incremental red light at night has the potential to be cost-effective for fresh organic basil production in controlled environments.  
  Address  
  Corporate Author Thesis  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0008-4220 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 1955  
Permanent link to this record
 

 
Author Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A. url  doi
openurl 
  Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
  Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal (up) Cancer Control  
  Volume 25 Issue 1 Pages 1073274818812908  
  Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED  
  Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.  
  Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher SAGE Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1073-2748 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30477310; PMCID:PMC6259078 Approved no  
  Call Number IDA @ john @ Serial 2143  
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Author Madahi, P.-G.; Ivan, O.; Adriana, B.; Diana, O.; Carolina, E. url  doi
openurl 
  Title Constant light during lactation programs circadian and metabolic systems Type Journal Article
  Year 2018 Publication Chronobiology International Abbreviated Journal (up) Chronobiol Int  
  Volume 35 Issue 8 Pages 1153-1167  
  Keywords Animals  
  Abstract Exposure to light at night is a disruptive condition for the adult circadian system, leading to arrhythmicity in nocturnal rodents. Circadian disruption is a risk factor for developing physiological and behavioral alterations, including weight gain and metabolic disease. During early stages of development, the circadian system undergoes a critical period of adjustment, and it is especially vulnerable to altered lighting conditions that may program its function, leading to long-term effects. We hypothesized that during lactation a disrupted light-dark cycle due to light at night may disrupt the circadian system and in the long term induce metabolic disorders. Here we explored in pups, short- and long-term effects of constant light (LL) during lactation. In the short term, LL caused a loss of rhythmicity and a reduction in the immunopositive cells of VIP, AVP, and PER1 in the suprachiasmatic nucleus (SCN). In the short term, the affection on the circadian clock in the pups resulted in body weight gain, loss of daily rhythms in general activity, plasma glucose and triglycerides (TG). Importantly, the DD conditions during development also induced altered daily rhythms in general activity and in the SCN. Exposure to LD conditions after lactation did not restore rhythmicity in the SCN, and the number of immunopositve cells to VIP, AVP, and PER1 remained reduced. In the long term, daily rhythmicity in general activity was restored; however, daily rhythms in glucose and TG remained disrupted, and daily mean levels of TG were significantly increased. Present results point out the programming role played by the LD cycle during early development in the function of the circadian system and on metabolism. This study points out the risk represented by exposure to an altered light-dark cycle during early stages of development. ABBREVIATIONS: AVP: arginine vasopressin peptide; CRY: cryptochrome; DD: constant darkness; DM: dorsomedial; LD: light-dark cycle; LL: constant light; NICUs: neonatal intensive care units; P: postnatal days; PER: period; S.E.M.: standard error of the mean; SCN: suprachiasmatic nucleus; TG: triglycerides; VIP: vasointestinal peptide; VL: ventrolateral; ZT: zeitgeber time.  
  Address a Facultad de Medicina , Universidad Nacional Autonoma de Mexico, UNAM , Mexico City , Mexico  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29688088 Approved no  
  Call Number GFZ @ kyba @ Serial 1884  
Permanent link to this record
 

 
Author Rybnikova, N.; Portnov, B.A. url  doi
openurl 
  Title Population-level study links short-wavelength nighttime illumination with breast cancer incidence in a major metropolitan area Type Journal Article
  Year 2018 Publication Chronobiology International Abbreviated Journal (up) Chronobiol Int  
  Volume 35 Issue 9 Pages 1198-1208  
  Keywords Human Health  
  Abstract Several population-level studies revealed a positive association between breast cancer (BC) incidence and artificial light at night (ALAN) exposure. However, the effect of short-wavelength illumination, implicated by laboratory research and small-scale cohort studies as the main driving force behind BC-ALAN association, has not been supported by any population-level study carried out to date. We investigated a possible link between BC and ALAN of different subspectra using a multi-spectral year-2011 satellite image, taken from the International Space Station, and superimposing it with year-2013 BC incidence data available for the Great Haifa Metropolitan Area in Israel. The analysis was performed using both ordinary least square (OLS) and spatial dependency models, controlling for socioeconomic and locational attributes of the study area. The study revealed strong associations between BC and blue and green light subspectra (B = 0.336 +/- 0.001 and B = 0.335 +/- 0.002, respectively; p < 0.01), compared to a somewhat weaker effect for the red subspectrum (B = 0.056 +/- 0.001; p < 0.01). However, spatial dependency models, controlling for spatial autocorrelation of regression residuals, confirmed only a positive association between BC incidence and short-wavelength (blue) ALAN subspectrum (z = 2.462, p < 0.05) while reporting insignificant associations between BC and either green (z = 1.425, p > 0.1) or red (z = -0.604, p > 0.1) subspectra. The obtained result is in line with the results of laboratory- and small-scale cohort studies linking short-wavelength nighttime illumination with circadian disruption and melatonin suppression. The detected effect of blue lights on BC incidence may help to develop informed illumination policies aimed at minimizing the adverse health effects of ALAN exposure on human health.  
  Address a Department of Natural Resources and Environmental Management , University of Haifa , Haifa , Israel  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29768068 Approved no  
  Call Number GFZ @ kyba @ Serial 1906  
Permanent link to this record
 

 
Author Maroni, M.J.; Capri, K.M.; Cushman, A.V.; Monteiro De Pina, I.K.; Chasse, M.H.; Seggio, J.A. url  doi
openurl 
  Title Constant light alters serum hormone levels related to thyroid function in male CD-1 mice Type Journal Article
  Year 2018 Publication Chronobiology International Abbreviated Journal (up) Chronobiol Int  
  Volume 35 Issue 10 Pages 1456-1463  
  Keywords Animals  
  Abstract Disruptions to the circadian rhythm can lead to altered metabolism. Modification of thyroid function may be a reason why circadian misalignment may contribute to future metabolic disorders. We investigated whether circadian disruption through constant light (LL) can lead to variations in hormone levels associated with thyroid function. Mice were exposed to LL or a 12:12 Light:Dark (LD) cycle for 6 weeks; then glucose tolerance and thyroid hormone levels were measured at ZT 6 and ZT 18. There was day/night variation in glucose tolerance, but LL had no effect. LL reduced TSH, increased fT4, and abolished day/night variation in fT3 and leptin. These findings illustrate that LL alters thyroid-related hormones, providing evidence of a link between circadian disruption and thyroid function.  
  Address a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29953263 Approved no  
  Call Number GFZ @ kyba @ Serial 1958  
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