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Author Chen, Y.; Cheng, M.; Su, T.; Gao, T.; Yu, W.
Title Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats Type Journal Article
Year 2018 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun
Volume in press Issue Pages
Keywords Animals
Abstract Constant light exposure is widespread in the intensive care unit (ICU) and could increase the rate of brain dysfunction as delirium and sleep disorders in critical patients. And the activation of hypothalamic neuropeptides is proved to play a crucial role in regulating hypercatabolism, especially skeletal muscle wasting in critical patients, which could lead to serious complications and poor prognosis. Here we investigated the hypothesis that constant light exposure could aggravate skeletal muscle wasting in endotoxemia rats and whether it was associated with alterations of circadian clock and hypothalamic proopiomelanocortin(POMC) expression. Fifty-four adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide(LPS) or saline, subjected to constant light or a 12:12h light-dark cycle for 7 days. On day 8, rats were sacrificed across six time points in 24h and hypothalamus tissues and skeletal muscle were obtained. Rates of muscle wasting were measured by 3-methylhistidine(3-MH) and tyrosine release as well as expression of two muscle atrophic genes, muscle ring finger 1(MuRF-1) and muscle atrophy F-box(MAFbx). The expression of circadian clock genes, silent information regulator 1(SIRT1), POMC and hypothalamic inflammatory cytokines were also detected. Results showed that LPS administration significantly increased hypothalamic POMC expression, inflammatory cytokine levels and muscle wasting rates. Meanwhile constant light exposure disrupted the circadian rhythm, declined the expression of SIRT1 as well as aggravated hypothalamic POMC overexpression and skeletal muscle wasting in rats with endotoxemia. Taken together, the results demonstrated that constant light exposure could aggravate POMC-mediated skeletal muscle wasting in endotoxemia rats, which is associated with alteration of circadian clocks and SIRT1 in the hypothalamus.
Address (down) Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: yudrnj2@163.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0006-291X ISBN Medium
Area Expedition Conference
Notes PMID:30528733 Approved no
Call Number GFZ @ kyba @ Serial 2134
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Author Vetter, C.
Title Circadian disruption: What do we actually mean? Type Journal Article
Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci
Volume in press Issue Pages in press
Keywords Review; Human Health
Abstract The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced during travel across time zones, will eventually result in re-synchronization to the local environmental time cues, but this re-synchronization is oftentimes accompanied by adverse short-term consequences. When such challenges are experienced chronically, adaptation may not be achieved, as for example in the case of rotating night shift workers. The transient and chronic disturbance of the circadian system is most frequently referred to as “circadian disruption”, but many other terms have been proposed and used to refer to similar situations. It is now beyond doubt that the circadian system contributes to health and disease, emphasizing the need for clear terminology when describing challenges to the circadian system and their consequences. The goal of this review is to provide an overview of the terms used to describe disruption of the circadian system, discuss proposed quantifications of disruption in experimental and observational settings with a focus on human research, and highlight limitations and challenges of currently available tools. For circadian research to advance as a translational science, clear, operationalizable, and scalable quantifications of circadian disruption are key, as they will enable improved assessment and reproducibility of results, ideally ranging from mechanistic settings, including animal research, to large-scale randomized clinical trials. This article is protected by copyright. All rights reserved.
Address (down) Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0953-816X ISBN Medium
Area Expedition Conference
Notes PMID:30402904 Approved no
Call Number GFZ @ kyba @ Serial 2057
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Author Kozaki, T.; Hidaka, Y.; Takakura, J.-Y.; Kusano, Y.
Title Suppression of salivary melatonin secretion under 100-Hz flickering and non-flickering blue light Type Journal Article
Year 2018 Publication Journal of Physiological Anthropology Abbreviated Journal J Physiol Anthropol
Volume 37 Issue 1 Pages 23
Keywords Human Health
Abstract BACKGROUND: Bright light at night is known to suppress melatonin secretion. Novel photoreceptors named intrinsically photosensitive retinal ganglion cells (ipRGCs) are mainly responsible for projecting dark/bright information to the suprachiasmatic nucleus and thus regulating the circadian system. However, it has been shown that the amplitude of the electroretinogram of ipRGCs is considerably lower under flickering light at 100 Hz than at 1-5 Hz, suggesting that flickering light may also affect the circadian system. Therefore, in this study, we evaluated light-induced melatonin suppression under flickering and non-flickering light. METHODS: Twelve male participants between the ages of 20 and 23 years (mean +/- S.D. = 21.6 +/- 1.5 years) were exposed to three light conditions (dim, 100-Hz flickering, and non-flickering blue light) from 1:00 A.M. to 2:30 A.M., and saliva samples were obtained just before 1:00 A.M. and at 1:15, 1:30, 2:00, and 2:30 A.M. RESULTS: A repeated measures t test with Bonferroni correction showed that at 1:15 A.M., melatonin concentrations were significantly lower following exposure to non-flickering light compared with dim light, whereas there was no significant difference between the dim and 100-Hz flickering light conditions. By contrast, after 1:30 A.M., the mean melatonin concentrations were significantly lower under both 100-Hz flickering and non-flickering light than under dim light. CONCLUSION: Although melatonin suppression rate tended to be lower under 100-Hz flickering light than under non-flickering light at the initial 15 min of the light exposure, the present study suggests that 100-Hz flickering light may have the same impact on melatonin secretion as non-flickering light.
Address (down) Department of Health and Nutrition Sciences, Nishikyushu University, Kanzaki, Japan
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1880-6791 ISBN Medium
Area Expedition Conference
Notes PMID:30340620 Approved no
Call Number GFZ @ kyba @ Serial 2039
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Author Kernbach, M.E.; Hall, R.J.; Burkett-Cadena, N.; Unnasch, T.R.; Martin, L.B.
Title Dim light at night: physiological effects and ecological consequences for infectious disease Type Journal Article
Year 2018 Publication Integrative and Comparative Biology Abbreviated Journal Integr Comp Biol
Volume 58 Issue 5 Pages 995-1007
Keywords Animals
Abstract Light pollution has emerged as a pervasive component of land development over the past century. Several detrimental impacts of this anthropogenic influence have been identified in night shift workers, laboratory rodents, and a plethora of wildlife species. Circadian, or daily, patterns are interrupted by the presence of light at night and have the capacity to alter rhythmic physiological or behavioral characteristics. Indeed, biorhythm disruption can lead to metabolic, reproductive, and immunological dysfunction depending on the intensity, timing, duration and wavelength of light exposure. Light pollution, in many forms and by many pathways, is thus apt to affect the nature of host-pathogen interactions. However, no research has yet investigated this possibility. The goal of this manuscript is to outline how dim light at night (dLAN), a relevant and common form of light pollution, may affect disease dynamics by interrupting circadian rhythms and regulation of immune responses as well as opportunities for host-parasite interactions and subsequent transmission risk including spillover into humans. We close by proposing some promising interventions including alternative lighting methods or vector control efforts.
Address (down) Department of Global Health, University of South Florida, Tampa FL
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1540-7063 ISBN Medium
Area Expedition Conference
Notes PMID:29939262 Approved no
Call Number GFZ @ kyba @ Serial 1946
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Author Tripathy, B.R.; Sajjad, H.; Elvidge, C.D.; Ting, Y.; Pandey, P.C.; Rani, M.; Kumar, P.
Title Modeling of Electric Demand for Sustainable Energy and Management in India Using Spatio-Temporal DMSP-OLS Night-Time Data Type Journal Article
Year 2018 Publication Environmental Management Abbreviated Journal Environ Manage
Volume 61 Issue 4 Pages 615-623
Keywords Remote Sensing
Abstract Changes in the pattern of electric power consumption in India have influenced energy utilization processes and socio-economic development to greater extent during the last few decades. Assessment of spatial distribution of electricity consumption is, thus, essential for projecting availability of energy resource and planning its infrastructure. This paper makes an attempt to model the future electricity demand for sustainable energy and its management in India. The nighttime light database provides a good approximation of availability of energy. We utilized defense meteorological satellite program-operational line-scan system (DMSP-OLS) nighttime satellite data, electricity consumption (1993-2013), gross domestic product (GDP) and population growth to construct the model. We also attempted to examine the sensitiveness of electricity consumption to GDP and population growth. The results revealed that the calibrated DMSP and model has provided realistic information on the electric demand with respect to GDP and population, with a better accuracy of r (2) = 0.91. The electric demand was found to be more sensitive to GDP (r = 0.96) than population growth (r = 0.76) as envisaged through correlation analysis. Hence, the model proved to be useful tool in predicting electric demand for its sustainable use and management.
Address (down) Department of Geography, Jamia Millia Islamia, New Delhi, 110025, India. pavan.jamia@gmail.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0364-152X ISBN Medium
Area Expedition Conference
Notes PMID:29282533 Approved no
Call Number GFZ @ kyba @ Serial 2484
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