toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author El-Bakry, H.A.; Ismail, I.A.; Soliman, S.S. url  doi
openurl 
  Title Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways Type Journal Article
  Year 2018 Publication Journal of Photochemistry and Photobiology. B, Biology Abbreviated Journal J Photochem Photobiol B  
  Volume 186 Issue Pages 69-80  
  Keywords Animals  
  Abstract The awareness of the interrelationship between immunosenescence and constant light exposure can provide new insights into the consequences of excessive exposure to light at night due to light pollution or shift work. Here, we investigated whether constant light exposure (LL) acts as an inducer of immunosenescence. We also determined the role of melatonin or turmeric in reversing the putative effects of constant light and explored for the first time the underlying molecular mechanisms. Young (3-4-month-old) rats were exposed daily to LL alone or in combination with each of melatonin and turmeric for 12weeks. A group of aged rats (18-months old; n=6) was used as a reference for natural immunosenescence. Constant light exposure resulted in remarkable pathophysiological alterations resembling those noticed in normal aged rats, manifested as apparent decreases in antioxidant activities as well as Nrf2 and DJ-1 expressions, striking augmentation in oxidative stress, proinflammatory cytokines and expression of TNFalpha, Bax, and p53 genes, and deleterious changes of lymphoid organs, Co-administration of melatonin or turmeric was able to reverse all alterations induced by LL through upregulation of Nrf2/DJ-1 and downregulation of p53/Bax pathways. These data suggest that LL accelerates immunosenescence via oxidative stress and apoptotic pathways. They also demonstrate for the first time that turmeric is comparable to melatonin in boosting the immune function and counteracting the LL-associated immunosenescence. These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence. However, to validate the effects of turmeric on humans further studies are warranted.  
  Address Department of Zoology & Entomology, Faculty of Science, Minia University, Egypt  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1011-1344 ISBN Medium  
  Area (down) Expedition Conference  
  Notes PMID:30015062 Approved no  
  Call Number GFZ @ kyba @ Serial 1984  
Permanent link to this record
 

 
Author Souman, J.L.; Borra, T.; de Goijer, I.; Schlangen, L.J.M.; Vlaskamp, B.N.S.; Lucassen, M.P. url  doi
openurl 
  Title Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature Type Journal Article
  Year 2018 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms  
  Volume 33 Issue 4 Pages 420-431  
  Keywords Human Health; Lighting  
  Abstract Studies with monochromatic light stimuli have shown that the action spectrum for melatonin suppression exhibits its highest sensitivity at short wavelengths, around 460 to 480 nm. Other studies have demonstrated that filtering out the short wavelengths from white light reduces melatonin suppression. However, this filtering of short wavelengths was generally confounded with reduced light intensity and/or changes in color temperature. Moreover, it changed the appearance from white light to yellow/orange, rendering it unusable for many practical applications. Here, we show that selectively tuning a polychromatic white light spectrum, compensating for the reduction in spectral power between 450 and 500 nm by enhancing power at even shorter wavelengths, can produce greatly different effects on melatonin production, without changes in illuminance or color temperature. On different evenings, 15 participants were exposed to 3 h of white light with either low or high power between 450 and 500 nm, and the effects on salivary melatonin levels and alertness were compared with those during a dim light baseline. Exposure to the spectrum with low power between 450 and 500 nm, but high power at even shorter wavelengths, did not suppress melatonin compared with dim light, despite a large difference in illuminance (175 vs. <5 lux). In contrast, exposure to the spectrum with high power between 450 and 500 nm (also 175 lux) resulted in almost 50% melatonin suppression. For alertness, no significant differences between the 3 conditions were observed. These results open up new opportunities for lighting applications that allow for the use of electrical lighting without disturbance of melatonin production.  
  Address Philips Lighting Research, Department Lighting Applications, Eindhoven, The Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0748-7304 ISBN Medium  
  Area (down) Expedition Conference  
  Notes PMID:29984614 Approved no  
  Call Number GFZ @ kyba @ Serial 1985  
Permanent link to this record
 

 
Author Ostrin, L.A. url  doi
openurl 
  Title Ocular and systemic melatonin and the influence of light exposure Type Journal Article
  Year 2018 Publication Clinical & Experimental Optometry Abbreviated Journal Clin Exp Optom  
  Volume in press Issue Pages in press  
  Keywords Vision; Review; Human Health  
  Abstract Melatonin is a neurohormone known to modulate a wide range of circadian functions, including sleep. The synthesis and release of melatonin from the pineal gland is heavily influenced by light stimulation of the retina, particularly through the intrinsically photosensitive retinal ganglion cells. Melatonin is also synthesised within the eye, although to a much lesser extent than in the pineal gland. Melatonin acts directly on ocular structures to mediate a variety of diurnal rhythms and physiological processes within the eye. The interactions between melatonin, the eye, and visual function have been the subject of a considerable body of recent research. This review is intended to provide a broad introduction for eye-care practitioners and researchers to the topic of melatonin and the eye. The first half of the review describes the anatomy and physiology of melatonin production: how visual inputs affect the pineal production of melatonin; how melatonin is involved in a variety of diurnal rhythms within the eye, including photoreceptor disc shedding, neuronal sensitivity, and intraocular pressure control; and melatonin production and physiological roles in retina, ciliary body, lens and cornea. The second half of the review describes clinical implications of light/melatonin interactions. These include light exposure and photoreceptor contributions in melatonin suppression, leading to consideration of how blue blockers, cataract, and light therapy might affect sleep and mood in patients. Additionally, the interactions between melatonin, sleep and refractive error development are discussed. A better understanding of environmental factors that affect melatonin and subsequent effects on physiological processes will allow clinicians to develop treatments and recommend modifiable behaviours to improve sleep, increase daytime alertness, and regulate ocular and systemic processes related to melatonin.  
  Address University of Houston College of Optometry, Houston, Texas, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0816-4622 ISBN Medium  
  Area (down) Expedition Conference  
  Notes PMID:30074278 Approved no  
  Call Number GFZ @ kyba @ Serial 1986  
Permanent link to this record
 

 
Author Gaynor, K.M.; Hojnowski, C.E.; Carter, N.H.; Brashares, J.S. url  doi
openurl 
  Title The influence of human disturbance on wildlife nocturnality Type Journal Article
  Year 2018 Publication Science (New York, N.Y.) Abbreviated Journal Science  
  Volume 360 Issue 6394 Pages 1232-1235  
  Keywords  
  Abstract Rapid expansion of human activity has driven well-documented shifts in the spatial distribution of wildlife, but the cumulative effect of human disturbance on the temporal dynamics of animals has not been quantified. We examined anthropogenic effects on mammal diel activity patterns, conducting a meta-analysis of 76 studies of 62 species from six continents. Our global study revealed a strong effect of humans on daily patterns of wildlife activity. Animals increased their nocturnality by an average factor of 1.36 in response to human disturbance. This finding was consistent across continents, habitats, taxa, and human activities. As the global human footprint expands, temporal avoidance of humans may facilitate human-wildlife coexistence. However, such responses can result in marked shifts away from natural patterns of activity, with consequences for fitness, population persistence, community interactions, and evolution.  
  Address Department of Environmental Science, Policy, and Management, University of California-Berkeley, Berkeley, CA 94720, USA  
  Corporate Author Thesis  
  Publisher AAAS Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0036-8075 ISBN Medium  
  Area (down) Expedition Conference  
  Notes PMID:29903973 Approved no  
  Call Number IDA @ john @ Serial 1988  
Permanent link to this record
 

 
Author Mard, J.; Di Baldassarre, G.; Mazzoleni, M. url  doi
openurl 
  Title Nighttime light data reveal how flood protection shapes human proximity to rivers Type Journal Article
  Year 2018 Publication Science Advances Abbreviated Journal Sci Adv  
  Volume 4 Issue 8 Pages eaar5779  
  Keywords Remote Sensing  
  Abstract To understand the spatiotemporal changes of flood risk, we need to determine the way in which humans adapt and respond to flood events. One adaptation option consists of resettling away from flood-prone areas to prevent or reduce future losses. We use satellite nighttime light data to discern the relationship between long-term changes in human proximity to rivers and the occurrence of catastrophic flood events. Moreover, we explore how these relationships are influenced by different levels of structural flood protection. We found that societies with low protection levels tend to resettle further away from the river after damaging flood events. Conversely, societies with high protection levels show no significant changes in human proximity to rivers. Instead, such societies continue to rely heavily on structural measures, reinforcing flood protection and quickly resettling in flood-prone areas after a flooding event. Our work reveals interesting aspects of human adaptation to flood risk and offers key insights for comparing different risk reduction strategies. In addition, this study provides a framework that can be used to further investigate human response to floods, which is relevant as urbanization of floodplains continues and puts more people and economic assets at risk.  
  Address IHE Delft Institute for Water Education, 2611 AX Delft, Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2375-2548 ISBN Medium  
  Area (down) Expedition Conference  
  Notes PMID:30140738; PMCID:PMC6105301 Approved no  
  Call Number GFZ @ kyba @ Serial 1989  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: