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Author (down) Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A.
Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control
Volume 25 Issue 1 Pages 1073274818812908
Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED
Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.
Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1073-2748 ISBN Medium
Area Expedition Conference
Notes PMID:30477310; PMCID:PMC6259078 Approved no
Call Number IDA @ john @ Serial 2143
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Author (down) Zhou, Y.; Zhang, H.-K.; Liu, F.; Lei, G.; Liu, P.; Jiao, T.; Dang, Y.-H.
Title Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice Type Journal Article
Year 2018 Publication Frontiers in Behavioral Neuroscience Abbreviated Journal Front Behav Neurosci
Volume 12 Issue Pages 110
Keywords Animals
Abstract In recent years, the environmental impact of artificial light at night has been a rapidly growing global problem, affecting 99% of the population in the US and Europe, and 62% of the world population. The present study utilized a mouse model exposed to long-term artificial light and light deprivation to explore the impact of these conditions on emotion and cognition. Based on the potential links between histidine triad nucleotide binding protein 1 (HINT1) and mood disorders, we also examined the expression of HINT1 and related apoptosis factors in the suprachiasmatic nucleus (SCN), prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus (Hip). Mice exposed to constant light (CL) exhibited depressive- and anxiety-like behaviors, as well as impaired spatial memory, as demonstrated by an increased immobility time in the tail suspension and forced swimming tests, less entries and time spent in the open arms of elevated plus-maze, and less platform site crossings and time spent in the target quadrant in the Morris water maze (MWM). The effects of constant darkness (CD) partially coincided with long-term illumination, except that mice in the CD group failed to show anxiety-like behaviors. Furthermore, HINT1 was upregulated in four encephalic regions, indicating that HINT1 may be involved in mood disorders and cognitive impairments due to altered light exposure. The apoptosis-related proteins, BAX and BCL-2, showed the opposite expression pattern, reflecting an activated apoptotic pathway. These findings suggest that exposure to CL and/or darkness can induce significant changes in affective and cognitive responses, possibly through HINT1-induced activation of apoptotic pathways.
Address College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1662-5153 ISBN Medium
Area Expedition Conference
Notes PMID:29937721; PMCID:PMC6002487 Approved no
Call Number NC @ ehyde3 @ Serial 2094
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Author (down) Zhou, Y.; Li, X.; Asrar, G.R.; Smith, S.J.; Imhoff, M.
Title A global record of annual urban dynamics (1992–2013) from nighttime lights Type Journal Article
Year 2018 Publication Remote Sensing of Environment Abbreviated Journal Remote Sensing of Environment
Volume 219 Issue Pages 206-220
Keywords Remote Sensing
Abstract The nighttime light (NTL) observations from Defense Meteorological Satellite Program/Operational Linescane System (DMSP/OLS) offer great potentials to study urban dynamics from regional to global scales, for more than two decades. In this paper, we presented a new approach to develop spatially and temporally consistent global urban maps from 1992 to 2013, using the DMSP/OLS NTL observations. First, potential urban clusters were delineated using the NTL data and a segmentation method. Then, a quantile-based approach was used to remove rural and suburban areas sequentially in the potential urban clusters. Finally, the derived series of urban extents in the entire study period (1992–2013) were improved for temporal consistency. We found the percentage of global urban areas relative to the world's land surface area increased from 0.23% in 1992 to 0.53% in 2013. Asia is the continent with the most significant urban growth, worldwide. The time series of global urban maps were evaluated for the spatial agreement and temporal consistency using a variety of widely used independent land-cover products. This evaluation indicates that the proposed approach is robust and performs well in deriving global urban dynamics across different spatial scales, i.e., cluster, province (or state), country, and region. Moreover, this quantile-based approach is advantageous, compared with other methods used in previous studies, because it does not require additional data for enhancement or calibration. The new time series of urban maps from this study offer a new dataset for studying global urbanization during the past decades and unique information to explore potential future trajectories of urban development, which appears to be distinct for different nations/regions, globally. Such information is pre-requisite for achieving the sustainable development goals, and associated targets, during ensuing decades.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0034-4257 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2048
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Author (down) Zheng, Q.; Weng, Q.; Huang, L.; Wang, K.; Deng, J.; Jiang, R.; Ye, Z.; Gan, M.
Title A new source of multi-spectral high spatial resolution night-time light imagery—JL1-3B Type Journal Article
Year 2018 Publication Remote Sensing of Environment Abbreviated Journal Remote Sensing of Environment
Volume 215 Issue Pages 300-312
Keywords Remote Sensing
Abstract Artificial light at night (ALAN) provides a unique footprint of human activities and settlements. However, the adverse effects of ALAN on human health and ecosystems have not been well understood. Because of a lack of high resolution data, studies of ALAN in China have been confined to coarse resolution, and fine-scale details are missing. The fine details of ALAN are pertinent, because the highly dense population in Chinese cities has created a distinctive urban lighting pattern. In this paper, we introduced a new generation of high spatial resolution and multi-spectral night-time light imagery from the satellite JL1-3B. We examined its effectiveness for monitoring the spatial pattern and discriminating the types of artificial light based on a case study of Hangzhou, China. Specifically, local Moran's I analysis was applied to identify artificial light hotspots. Then, we analyzed the relationship between artificial light brightness and land uses at the parcel-level, which were generated from GF-2 imagery and open social datasets. Third, a machine learning based method was proposed to discriminate the type of lighting sources – between high pressure sodium lamps (HPS) and light-emitting diode lamps (LED) – by incorporating their spectral information and morphology feature. The result shows a complicated heterogeneity of illumination characteristics across different land uses, where main roads, commercial and institutional areas were brightly lit while residential area, industrial area and agricultural land were dark at night. It further shows that the proposed method was effective at separating light emitted by HPS and LED, with an overall accuracy and kappa coefficient of 83.86% and 0.67, respectively. This study demonstrates the effectiveness of JL1-3B and its superiority over previous night-time light data in detecting details of lighting objects and the nightscape pattern, and suggests that JL1-3B and alike could open up new opportunities for the advancement of night-time remote sensing.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0034-4257 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 1945
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Author (down) Zheng, Q.; Jiang, R.; Wang, K.; Huang, L.; Ye, Z.; Gan, M.; Ji, B.
Title Monitoring the trajectory of urban nighttime light hotspots using a Gaussian volume model Type Journal Article
Year 2018 Publication International Journal of Applied Earth Observation and Geoinformation Abbreviated Journal International Journal of Applied Earth Observation and Geoinformation
Volume 65 Issue Pages 24-34
Keywords Remote Sensing
Abstract Urban nighttime light hotspot is an ideal representation of the spatial heterogeneity of human activities within a city, which is sensitive to regional urban expansion pattern. However, most of previous studies related to nighttime light imageries focused on extracting urban extent, leaving the spatial variation of radiance intensity insufficiently explored. With the help of global radiance calibrated DMSP-OLS datasets (NTLgrc), we proposed an innovative framework to explore the spatio-temporal trajectory of polycentric urban nighttime light hotspots. Firstly, NTLgrc was inter-annually calibrated to improve the consistency. Secondly, multi-resolution segmentation and region-growing SVM classification were employed to remove blooming effect and to extract potential clusters. At last, the urban hotspots were identified by a Gaussian volume model, and the resulting parameters were used to quantitatively depict hotspot features (i.e., intensity, morphology and centroid dynamics). The result shows that our framework successfully captures hotspots in polycentric urban area, whose Ra2 are over 0.9. Meanwhile, the spatio-temporal dynamics of the hotspot features intuitively reveal the impact of the regional urban growth pattern and planning strategies on human activities. Compared to previous studies, our framework is more robust and offers an effective way to describe hotspot pattern. Also, it provides a more comprehensive and spatial-explicit understanding regarding the interaction between urbanization pattern and human activities. Our findings are expected to be beneficial to governors in term of sustainable urban planning and decision making.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0303-2434 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1771
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