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Author (down) Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A.
Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control
Volume 25 Issue 1 Pages 1073274818812908
Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED
Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.
Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1073-2748 ISBN Medium
Area Expedition Conference
Notes PMID:30477310; PMCID:PMC6259078 Approved no
Call Number IDA @ john @ Serial 2143
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Author (down) Zielinska-Dabkowska, K. M., & Schieck, A. F.
Title Designing digital displays and interactive media in today’s cities by night. Do we know enough about attracting attention to do so? Type Journal Article
Year 2018 Publication Conscious Cities Anthology Abbreviated Journal
Volume Issue Pages
Keywords Commentary; Lighting
Abstract With the huge transformation in the development of digital screen technology and its consistently decreasing cost, digital billboards are progressively replacing traditional static, two-dimensional poster advertisements in our cities1. Previously, due to the substantial expenditure involved, they were only available to major international brands with vast promotional resources to build their brand fame. Today, however, they are being used increasingly by advertisers to deliver all kinds of messages from simple ones to more sophisticated, interactive storytelling. Soon, however, even newer ways of purchasing advertisements using computers will be introduced by the outdoor media industry to address the public, so potentially everybody will be able to rent out available advertising space and communicate the message. But are we ready for this next step? As there are no proper guidelines or regulations in place for this new medium in the urban realm, today we are facing issues such as no integration of the display’s location into the built environment, no specifications based on knowledge of human perception and the human centric design approach, no control over its content quality, and so called ‘display blindness’2 seems to be a common collective urban experience at night. Taking London as one of the most cutting-edge outdoor digital advertising environments in the world3 (with the largest number of these screens traditionally located in or in close proximity to Piccadilly Circus) this paper discusses various aspects of this new medium. Besides the layout and geometry of the space, it also focuses on navigation and attracting the visual attention of passers-by at night in a practical human oriented context. Additionally, questions regarding complex sensory, social, special and interactional issues and the necessity for interdisciplinary collaboration have been addressed.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ intern @ Serial 2351
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Author (down) Zielinska-Dabkowska, K. M. & Xavia, K.
Title An overview of the cognitive and biological effects of city nighttime illumination including a London case study Type Journal Article
Year 2018 Publication The Centre for Conscious Design Abbreviated Journal
Volume Issue Pages
Keywords Lighting
Abstract Current scientific research demonstrates how critical the effects of city nighttime illumination are upon cognitive and biological health1 – which needs to be adequately acknowledged, understood and addressed by conscious cities and the plans they develop. Until recent decades, the design of nighttime lighting was determined mostly by electrical engineers who often applied technical standards to meet the requirements of vehicle-focused cities. Unfortunately, consideration of pedestrians and their visual needs to navigate throughout urbanscapes at night were ignored, and so too, was the impact that artificial lighting might have on them, and the environment. Today, the majority of urban city lighting has been installed without full awareness of its impact, and as a result, artificial light at night (ALAN) and light pollution have become an obvious public nuisance, a health risk and an environmental burden2,3. While poor lighting has its drawbacks, a lack of lighting can have many positive aspects, and urban settings can benefit from protecting, preserving and promoting natural darkness. We present two recent planning and design initiatives of London, in the UK, where the quality of light and value of darkness were not given the degree of attention and consideration they deserve. This paper has particular relevance for urban policy makers, city planners, architects, designers, consultants and researchers as it explores the various problems caused by the obvious lack of responsible nighttime illumination.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ intern @ Serial 2296
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Author (down) Zhou, Y.; Zhang, H.-K.; Liu, F.; Lei, G.; Liu, P.; Jiao, T.; Dang, Y.-H.
Title Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice Type Journal Article
Year 2018 Publication Frontiers in Behavioral Neuroscience Abbreviated Journal Front Behav Neurosci
Volume 12 Issue Pages 110
Keywords Animals
Abstract In recent years, the environmental impact of artificial light at night has been a rapidly growing global problem, affecting 99% of the population in the US and Europe, and 62% of the world population. The present study utilized a mouse model exposed to long-term artificial light and light deprivation to explore the impact of these conditions on emotion and cognition. Based on the potential links between histidine triad nucleotide binding protein 1 (HINT1) and mood disorders, we also examined the expression of HINT1 and related apoptosis factors in the suprachiasmatic nucleus (SCN), prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus (Hip). Mice exposed to constant light (CL) exhibited depressive- and anxiety-like behaviors, as well as impaired spatial memory, as demonstrated by an increased immobility time in the tail suspension and forced swimming tests, less entries and time spent in the open arms of elevated plus-maze, and less platform site crossings and time spent in the target quadrant in the Morris water maze (MWM). The effects of constant darkness (CD) partially coincided with long-term illumination, except that mice in the CD group failed to show anxiety-like behaviors. Furthermore, HINT1 was upregulated in four encephalic regions, indicating that HINT1 may be involved in mood disorders and cognitive impairments due to altered light exposure. The apoptosis-related proteins, BAX and BCL-2, showed the opposite expression pattern, reflecting an activated apoptotic pathway. These findings suggest that exposure to CL and/or darkness can induce significant changes in affective and cognitive responses, possibly through HINT1-induced activation of apoptotic pathways.
Address College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1662-5153 ISBN Medium
Area Expedition Conference
Notes PMID:29937721; PMCID:PMC6002487 Approved no
Call Number NC @ ehyde3 @ Serial 2094
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Author (down) Zhou, Y.; Li, X.; Asrar, G.R.; Smith, S.J.; Imhoff, M.
Title A global record of annual urban dynamics (1992–2013) from nighttime lights Type Journal Article
Year 2018 Publication Remote Sensing of Environment Abbreviated Journal Remote Sensing of Environment
Volume 219 Issue Pages 206-220
Keywords Remote Sensing
Abstract The nighttime light (NTL) observations from Defense Meteorological Satellite Program/Operational Linescane System (DMSP/OLS) offer great potentials to study urban dynamics from regional to global scales, for more than two decades. In this paper, we presented a new approach to develop spatially and temporally consistent global urban maps from 1992 to 2013, using the DMSP/OLS NTL observations. First, potential urban clusters were delineated using the NTL data and a segmentation method. Then, a quantile-based approach was used to remove rural and suburban areas sequentially in the potential urban clusters. Finally, the derived series of urban extents in the entire study period (1992–2013) were improved for temporal consistency. We found the percentage of global urban areas relative to the world's land surface area increased from 0.23% in 1992 to 0.53% in 2013. Asia is the continent with the most significant urban growth, worldwide. The time series of global urban maps were evaluated for the spatial agreement and temporal consistency using a variety of widely used independent land-cover products. This evaluation indicates that the proposed approach is robust and performs well in deriving global urban dynamics across different spatial scales, i.e., cluster, province (or state), country, and region. Moreover, this quantile-based approach is advantageous, compared with other methods used in previous studies, because it does not require additional data for enhancement or calibration. The new time series of urban maps from this study offer a new dataset for studying global urbanization during the past decades and unique information to explore potential future trajectories of urban development, which appears to be distinct for different nations/regions, globally. Such information is pre-requisite for achieving the sustainable development goals, and associated targets, during ensuing decades.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0034-4257 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2048
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