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Author Chen, Y.; Cheng, M.; Su, T.; Gao, T.; Yu, W. url  doi
openurl 
  Title Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats Type Journal Article
  Year 2018 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume in press Issue Pages  
  Keywords Animals  
  Abstract Constant light exposure is widespread in the intensive care unit (ICU) and could increase the rate of brain dysfunction as delirium and sleep disorders in critical patients. And the activation of hypothalamic neuropeptides is proved to play a crucial role in regulating hypercatabolism, especially skeletal muscle wasting in critical patients, which could lead to serious complications and poor prognosis. Here we investigated the hypothesis that constant light exposure could aggravate skeletal muscle wasting in endotoxemia rats and whether it was associated with alterations of circadian clock and hypothalamic proopiomelanocortin(POMC) expression. Fifty-four adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide(LPS) or saline, subjected to constant light or a 12:12h light-dark cycle for 7 days. On day 8, rats were sacrificed across six time points in 24h and hypothalamus tissues and skeletal muscle were obtained. Rates of muscle wasting were measured by 3-methylhistidine(3-MH) and tyrosine release as well as expression of two muscle atrophic genes, muscle ring finger 1(MuRF-1) and muscle atrophy F-box(MAFbx). The expression of circadian clock genes, silent information regulator 1(SIRT1), POMC and hypothalamic inflammatory cytokines were also detected. Results showed that LPS administration significantly increased hypothalamic POMC expression, inflammatory cytokine levels and muscle wasting rates. Meanwhile constant light exposure disrupted the circadian rhythm, declined the expression of SIRT1 as well as aggravated hypothalamic POMC overexpression and skeletal muscle wasting in rats with endotoxemia. Taken together, the results demonstrated that constant light exposure could aggravate POMC-mediated skeletal muscle wasting in endotoxemia rats, which is associated with alteration of circadian clocks and SIRT1 in the hypothalamus.  
  Address Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: yudrnj2@163.com  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN (up) 0006-291X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30528733 Approved no  
  Call Number GFZ @ kyba @ Serial 2134  
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Author Guetté, A.; Godet, L.; Juigner, M.; Robin, M. url  doi
openurl 
  Title Worldwide increase in Artificial Light At Night around protected areas and within biodiversity hotspots Type Journal Article
  Year 2018 Publication Biological Conservation Abbreviated Journal Biological Conservation  
  Volume 223 Issue Pages 97-103  
  Keywords Remote Sensing; Ecology; Conservation  
  Abstract Artificial Light At Night (ALAN) has several adverse impacts on biodiversity, and it has been recently used as a proxy to monitor human encroachment on landscapes at large spatial scales. The extent to which ALAN affects protected areas (PAs) and biodiversity hotspots (BHs) remains however untested at large spatial scales. We used this proxy to assess the spatial and temporal trends in the anthropization at a global scale within and around PAs and BHs. We found that ALAN is low and stable over time within PAs, but is the highest in a first outer belt (<25 km) around PAs, and tends to increase in a second outer belt (25–75 km). In the meantime, ALAN is higher within BHs than outside, and is even the highest and increasing over time in an inner belt, close to their periphery. Our results suggest that although PAs are creating safety zones in terms of ALAN, they tend to be more and more isolated from each other by a concentric human encroachment. In contrast, BHs are submitted to an increasing human pressure, especially in their inner periphery. Overall, we suggest integrating ALAN in large-scale conservation policies.  
  Address  
  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0006-3207 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 1890  
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Author Johns, L.E.; Jones, M.E.; Schoemaker, M.J.; McFadden, E.; Ashworth, A.; Swerdlow, A.J. url  doi
openurl 
  Title Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 118 Issue Pages 600-606  
  Keywords Human Health  
  Abstract BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors. RESULTS: There was no association between LAN level and breast cancer risk overall (highest compared with lowest LAN level at recruitment: HR=1.01, 95% confidence interval (CI): 0.88-1.15), or for invasive (HR=0.98, 95% CI: 0.85-1.13) or in situ (HR=0.96, 95% CI: 0.83-1.11) breast cancer, or oestrogen-receptor (ER) positive (HR=0.98, 95% CI: 0.84-1.14); or negative (HR=1.16, 95% CI: 0.82-1.65) tumours separately. The findings did not differ by menopausal status. Adjusting for sleep duration, sleeping at unusual times (non-peak sleep) and history of night work did not affect the results. Night waking with exposure to light, occurring around age 20, was associated with a reduced risk of premenopausal breast cancer (HR for breast cancer overall=0.74, 95% CI: 0.55-0.99; HR for ER-positive breast cancer=0.69, 95% CI: 0.49-0.97). CONCLUSIONS: In this prospective cohort analysis of LAN, there was no evidence that LAN exposure increased the risk of subsequent breast cancer, although the suggestion of a lower breast cancer risk in pre-menopausal women with a history of night waking in their twenties may warrant further investigation.British Journal of Cancer advance online publication, 23 January 2018; doi:10.1038/bjc.2017.359 www.bjcancer.com.  
  Address Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29360812 Approved no  
  Call Number LoNNe @ kyba @ Serial 1803  
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Author Mortazavi, S.M.J. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 118 Issue 11 Pages 1536  
  Keywords Commentary  
  Abstract  
  Address Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran. S.M.Javad.Mortazavi@fccc.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29769746 Approved no  
  Call Number GFZ @ kyba @ Serial 1911  
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Author Stevens, R.G. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume in press Issue Pages  
  Keywords Commentary; Human Health  
  Abstract  
  Address University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30283145 Approved no  
  Call Number GFZ @ kyba @ Serial 2035  
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