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Author Johns, L.E.; Jones, M.E.; Schoemaker, M.J.; McFadden, E.; Ashworth, A.; Swerdlow, A.J. url  doi
openurl 
  Title Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 118 Issue Pages 600-606  
  Keywords Human Health  
  Abstract BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors. RESULTS: There was no association between LAN level and breast cancer risk overall (highest compared with lowest LAN level at recruitment: HR=1.01, 95% confidence interval (CI): 0.88-1.15), or for invasive (HR=0.98, 95% CI: 0.85-1.13) or in situ (HR=0.96, 95% CI: 0.83-1.11) breast cancer, or oestrogen-receptor (ER) positive (HR=0.98, 95% CI: 0.84-1.14); or negative (HR=1.16, 95% CI: 0.82-1.65) tumours separately. The findings did not differ by menopausal status. Adjusting for sleep duration, sleeping at unusual times (non-peak sleep) and history of night work did not affect the results. Night waking with exposure to light, occurring around age 20, was associated with a reduced risk of premenopausal breast cancer (HR for breast cancer overall=0.74, 95% CI: 0.55-0.99; HR for ER-positive breast cancer=0.69, 95% CI: 0.49-0.97). CONCLUSIONS: In this prospective cohort analysis of LAN, there was no evidence that LAN exposure increased the risk of subsequent breast cancer, although the suggestion of a lower breast cancer risk in pre-menopausal women with a history of night waking in their twenties may warrant further investigation.British Journal of Cancer advance online publication, 23 January 2018; doi:10.1038/bjc.2017.359 www.bjcancer.com.  
  Address Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29360812 Approved no  
  Call Number LoNNe @ kyba @ Serial 1803  
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Author Mortazavi, S.M.J. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 118 Issue 11 Pages 1536  
  Keywords Commentary  
  Abstract  
  Address Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran. S.M.Javad.Mortazavi@fccc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29769746 Approved no  
  Call Number GFZ @ kyba @ Serial 1911  
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Author Stevens, R.G. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume in press Issue Pages  
  Keywords Commentary; Human Health  
  Abstract  
  Address University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30283145 Approved no  
  Call Number GFZ @ kyba @ Serial 2035  
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Author Kyba, C.C.M.; Spitschan, M. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume in press Issue Pages  
  Keywords Human Health; Commentary  
  Abstract  
  Address Department of Experimental Psychology, University of Oxford, Oxford, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30584260 Approved no  
  Call Number GFZ @ kyba @ Serial 2145  
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Author Gaydecki, P. url  doi
openurl 
  Title Automated moth flight analysis in the vicinity of artificial light Type Journal Article
  Year 2018 Publication Bulletin of Entomological Research Abbreviated Journal Bull Entomol Res  
  Volume 109 Issue 1 Pages 127-140  
  Keywords Instrumentation; Animals  
  Abstract Instrumentation and software for the automated analysis of insect flight trajectories is described, intended for quantifying the behavioural dynamics of moths in the vicinity of artificial light. For its time, this moth imaging system was relatively advanced and revealed hitherto undocumented insights into moth flight behaviour. The illumination source comprised a 125 W mercury vapour light, operating in the visible and near ultraviolet wavelengths, mounted on top of a mobile telescopic mast at heights of 5 and 7.1 m, depending upon the experiment. Moths were imaged in early September, at night and in field conditions, using a ground level video camera with associated optics including a heated steering mirror, wide angle lens and an electronic image intensifier. Moth flight coordinates were recorded at a rate of 50 images per second (fields) and transferred to a computer using a light pen (the only non-automated operation in the processing sequence). Software extracted ground speed vectors and, by instantaneous subtraction of wind speed data supplied by fast-response anemometers, the airspeed vectors. Accumulated density profiles of the track data revealed that moths spend most of their time at a radius of between 40 and 50 cm from the source, and rarely fly directly above it, from close range. Furthermore, the proportion of insects caught by the trap as a proportion of the number influenced by the light (and within the field of view of the camera) was very low; of 1600 individual tracks recorded over five nights, a total of only 12 were caught. Although trap efficiency is strongly dependent on trap height, time of night, season, moonlight and weather, the data analysis confirmed that moths do not exhibit straightforward positive phototaxis. In general, trajectory patterns become more complex with reduced distance from the illumination, with higher recorded values of speeds and angular velocities. However, these characteristics are further qualified by the direction of travel of the insect; the highest accelerations tended to occur when the insect was at close range, but moving away from the source. Rather than manifesting a simple positive phototaxis, the trajectories were suggestive of disorientation. Based on the data and the complex behavioural response, mathematical models were developed that described ideal density distribution in calm air and light wind speed conditions. The models did not offer a physiological hypothesis regarding the behavioural changes, but rather were tools for quantification and prediction. Since the time that the system was developed, instrumentation, computers and software have advanced considerably, allowing much more to be achieved at a small fraction of the original cost. Nevertheless, the analytical tools remain useful for automated trajectory analysis of airborne insects.  
  Address School of Electrical and Electronic Engineering, University of Manchester,Manchester M13 9PL,UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0007-4853 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29745349 Approved no  
  Call Number GFZ @ kyba @ Serial 1895  
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