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Author Masri, S.; Sassone-Corsi, P.
Title The emerging link between cancer, metabolism, and circadian rhythms Type Journal Article
Year 2018 Publication Nature Medicine Abbreviated Journal Nat Med
Volume 24 Issue (down) 12 Pages 1795-1803
Keywords Human Health; Review
Abstract The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
Address Department of Biological Chemistry, Center for Epigenetics and Metabolism, INSERM U1233, University of California Irvine, Irvine, CA, USA. psc@uci.edu
Corporate Author Thesis
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1078-8956 ISBN Medium
Area Expedition Conference
Notes PMID:30523327 Approved no
Call Number GFZ @ kyba @ Serial 2135
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Author Shor, E.; Potavskaya, R.; Kurtz, A.; Paik, I.; Huq, E.; Green, R.
Title PIF-mediated sucrose regulation of the circadian oscillator is light quality and temperature dependent Type Journal Article
Year 2018 Publication Genes Abbreviated Journal Genes (Basel)
Volume 9 Issue (down) 12 Pages
Keywords Plants
Abstract Studies are increasingly showing that metabolic and circadian (~24 h) pathways are strongly interconnected, with the circadian system regulating the metabolic state of the cell, and metabolic products feeding back to entrain the oscillator. In plants, probably the most significant impact of the circadian system on metabolism is in its reciprocal regulation of photosynthesis; however, the pathways by which this occurs are still poorly understood. We have previously shown that members of the basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME INTERACTING FACTOR (PIF) family are involved in the photosynthate entrainment of the circadian oscillator. In this paper, using Arabidopsis mutants and overexpression lines, we examine how temperature and light quality affect PIF-mediated sucrose signaling to the oscillator and examine the contributions of individual PIF members. Our results also show that the quality of light is important for PIF signaling, with red and blue lights having the opposite effects, and that temperature affects PIF-mediated sucrose signaling. We propose the light sensitivity of PIF-mediated sucrose entrainment of the oscillator may be important in enabling plants to distinguish between sucrose produced de novo from photosynthesis during the day and the sucrose products of starch degradation at the end of the night.
Address Department of Plant and Environmental Sciences, Institute for Life Sciences, Edmond J. Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, Israel. rgreen@mail.huji.ac.il
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2073-4425 ISBN Medium
Area Expedition Conference
Notes PMID:30551669; PMCID:PMC6316277 Approved no
Call Number GFZ @ kyba @ Serial 2155
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Author Zhao, Z., Zhou, Y., Tan, G., & Li, J.
Title Research progress about the effect and prevention of blue light on eyes Type Journal Article
Year 2018 Publication International Journal of Ophthalmology Abbreviated Journal
Volume 11 Issue (down) 12 Pages 1999-2003
Keywords Vision; Human Health; Review
Abstract In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light's effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment.
Address
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Notes Approved no
Call Number IDA @ intern @ Serial 2313
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Author Lee, H.
Title Do We Use Artificial Light Appropriately? Type Journal Article
Year 2018 Publication Psychiatry Investigation Abbreviated Journal
Volume 15 Issue (down) 12 Pages
Keywords Commentary; Human Health
Abstract
Address
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Notes Approved no
Call Number IDA @ intern @ Serial 2314
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Author Rabaza, O.; Molero-Mesa, E.; Aznar-Dols, F.; Gómez-Lorente, D.
Title Experimental Study of the Levels of Street Lighting Using Aerial Imagery and Energy Efficiency Calculation Type Journal Article
Year 2018 Publication Sustainability Abbreviated Journal Sustainability
Volume 10 Issue (down) 12 Pages 4365
Keywords Remote Sensing; Lighting
Abstract This article describes an innovative method for measuring lighting levels and other lighting parameters through the use of aerial imagery of towns and cities. Combined with electricity consumption data from smart electricity meters, it was possible to measure the energy efficiency of public lighting installations. The results of this study also confirmed that lighting measurements, installation material, luminaire position, and electricity consumption data can be easily integrated into geographic information systems (GIS). The main advantage of this new methodology is that it provides information about lighting installations in large areas in less time than more conventional procedures. It is thus a more effective way of obtaining the data required to calculate the energy efficiency of lighting levels and electricity consumption. There is even the possibility of generating street lighting maps that provide local administrations with up-to-date information regarding the status of public lighting installations in their city. In this way, modifications or improvements can be made to achieve greater energy savings and, if necessary, to correct the distribution or configuration of public lighting systems to make them more efficient and sustainable. This research studied levels of street lighting and calculated the energy efficiency in various streets of Deifontes (Granada), through the use of aerial imagery.
Address
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2071-1050 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2773
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