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Author Stern, M.; Broja, M.; Sansone, R.; Grone, M.; Skene, S.S.; Liebmann, J.; Suschek, C.V.; Born, M.; Kelm, M.; Heiss, C.
Title Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans Type Journal Article
Year 2018 Publication European Journal of Preventive Cardiology Abbreviated Journal Eur J Prev Cardiol
Volume 25 Issue 17 Pages 1875-1883
Keywords (up) Human Health; Blue light; blood pressure; endothelial function; forearm blood flow; pulse wave velocity
Abstract AIMS: Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also decrease blood pressure and increase endothelial function in healthy subjects. METHODS: In a randomised crossover study, 14 healthy male subjects were exposed on 2 days to monochromatic blue light or blue light with a filter foil (control light) over 30 minutes. We measured blood pressure (primary endpoint), heart rate, forearm vascular resistance, forearm blood flow, endothelial function (flow-mediated dilation), pulse wave velocity and plasma nitric oxide species, nitrite and nitroso compounds (secondary endpoints) during and up to 2 hours after exposure. RESULTS: Blue light exposure significantly decreased systolic blood pressure and increased heart rate as compared to control. In parallel, blue light significantly increased forearm blood flow, flow-mediated dilation, circulating nitric oxide species and nitroso compounds while it decreased forearm vascular resistance and pulse wave velocity. CONCLUSION: Whole body irradiation with visible blue light at real world doses improves blood pressure, endothelial function and arterial stiffness by nitric oxide released from photolabile intracutanous nitric oxide metabolites into circulating blood.
Address Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford GU2 7XH, UK. Email: c.heiss(at)
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2047-4873 ISBN Medium
Area Expedition Conference
Notes PMID:30196723 Approved no
Call Number IDA @ john @ Serial 2157
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Author Czeisler, C.A.
Title Housing Immigrant Children – The Inhumanity of Constant Illumination Type Journal Article
Year 2018 Publication The New England Journal of Medicine Abbreviated Journal N Engl J Med
Volume 379 Issue 2 Pages e3
Keywords (up) Human Health; Commentary
Abstract
Address From the Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, and the Division of Sleep Medicine, Harvard Medical School – both in Boston
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0028-4793 ISBN Medium
Area Expedition Conference
Notes PMID:29932841 Approved no
Call Number GFZ @ kyba @ Serial 1942
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Author Kyba, C.C.M.; Spitschan, M.
Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study' Type Journal Article
Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume in press Issue Pages
Keywords (up) Human Health; Commentary
Abstract
Address Department of Experimental Psychology, University of Oxford, Oxford, UK
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-0920 ISBN Medium
Area Expedition Conference
Notes PMID:30584260 Approved no
Call Number GFZ @ kyba @ Serial 2145
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Author Jones, B.A.
Title Spillover health effects of energy efficiency investments: Quasi-experimental evidence from the Los Angeles LED streetlight program Type Journal Article
Year 2018 Publication Journal of Environmental Economics and Management Abbreviated Journal Journal of Environmental Economics and Management
Volume 88 Issue Pages 283-299
Keywords (up) Human Health; LED; public health; outdoor lighting; Los Angeles; economics; energy efficiency; breast cancer; fossil fuel carbon emissions
Abstract Payback estimates of energy efficiency investments often ignore public health externalities. This is problematic in cases where spillover health effects are substantial, such as when the application of new technology alters environmental exposures. When health externalities are included in return on investment calculations, energy efficiency programs may look more or less attractive than suggested by conventional “energy savings only” estimates. This analysis exploits the quasi-experiment provided by the 2009 Los Angeles (LA) LED streetlight efficiency program to investigate the returns on investments inclusive of an originally estimated health externality. Using the synthetic control method, we find that the LED streetlight program is associated with a lagged increase in breast cancer mortality of 0.479 per 100,000. Inclusive of the effects of LEDs on breast cancer and avoided carbon emissions, the LA LED program provides a −146.2% 10-year return compared to +118.2% when health outcomes and carbon emissions are ignored.
Address Department of Economics, University of New Mexico, 1 UNM Drive, MSC 05 3060, Albuquerque, NM, 87131, USA; bajones(at)unm.edu
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0095-0696 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 1976
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Author Souman, J.L.; Borra, T.; de Goijer, I.; Schlangen, L.J.M.; Vlaskamp, B.N.S.; Lucassen, M.P.
Title Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature Type Journal Article
Year 2018 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume 33 Issue 4 Pages 420-431
Keywords (up) Human Health; Lighting
Abstract Studies with monochromatic light stimuli have shown that the action spectrum for melatonin suppression exhibits its highest sensitivity at short wavelengths, around 460 to 480 nm. Other studies have demonstrated that filtering out the short wavelengths from white light reduces melatonin suppression. However, this filtering of short wavelengths was generally confounded with reduced light intensity and/or changes in color temperature. Moreover, it changed the appearance from white light to yellow/orange, rendering it unusable for many practical applications. Here, we show that selectively tuning a polychromatic white light spectrum, compensating for the reduction in spectral power between 450 and 500 nm by enhancing power at even shorter wavelengths, can produce greatly different effects on melatonin production, without changes in illuminance or color temperature. On different evenings, 15 participants were exposed to 3 h of white light with either low or high power between 450 and 500 nm, and the effects on salivary melatonin levels and alertness were compared with those during a dim light baseline. Exposure to the spectrum with low power between 450 and 500 nm, but high power at even shorter wavelengths, did not suppress melatonin compared with dim light, despite a large difference in illuminance (175 vs. <5 lux). In contrast, exposure to the spectrum with high power between 450 and 500 nm (also 175 lux) resulted in almost 50% melatonin suppression. For alertness, no significant differences between the 3 conditions were observed. These results open up new opportunities for lighting applications that allow for the use of electrical lighting without disturbance of melatonin production.
Address Philips Lighting Research, Department Lighting Applications, Eindhoven, The Netherlands
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes PMID:29984614 Approved no
Call Number GFZ @ kyba @ Serial 1985
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