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Author Lee, S., Matsumori, K., Nishimura, K., Nishimura, Y., Ikeda, Y., Eto, T., & Higuchi, S.
Title Melatonin suppression and sleepiness in children exposed to blue-enriched white LED lighting at night Type Journal Article
Year 2018 Publication Physiological Reports Abbreviated Journal
Volume 6 Issue 24 Pages
Keywords (up) Human Health
Abstract Light-induced melatonin suppression in children is reported to be more sensitive to white light at night than that in adults; however, it is unclear whether it depends on spectral distribution of lighting. In this study, we investigated the effects of different color temperatures of LED lighting on children’s melatonin secretion during the night. Twenty-two healthy children (8.9  2.2 years old) and 20 adults (41.7  4.4 years old) participated in this

study. A between-subjects design with four combinations, including two age

groups (adults and children) and the two color temperature conditions

(3000 K and 6200 K), was used. The experiment was conducted for two consecutive nights. On the first night, saliva samples were collected every hour

under a dim light condition (<30 lx). On the second night, the participants

were exposed to either color temperature condition. Melatonin suppression in

children was greater than that in adults at both 3000 K and 6200 K condition.

The 6200 K condition resulted in greater melatonin suppression than did the

3000 K condition in children (P < 0.05) but not in adults. Subjective sleepiness in children exposed to 6200 K light was significantly lower than that in

children exposed to 3000 K light. In children, blue-enriched LED lighting has

a greater impact on melatonin suppression and it inhibits the increase in

sleepiness during night. Light with a low color temperature is recommended

at night, particularly for children’s sleep and circadian rhythm.
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Notes Approved no
Call Number IDA @ intern @ Serial 2312
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Author Pushkala, K., Gupta, P. D., & Geetha, R.
Title Differential Drift in Menarcheal Age in Blind and Sighted Girls Type Journal Article
Year 2018 Publication Gynaecology and Perinatology Abbreviated Journal
Volume 2 Issue 4 Pages 333-339
Keywords (up) Human Health
Abstract Our survey data show that menarcheal age, both in sighted and blind girls has drifted towards younger years compared to 50 years back, however, in sighted girls it has gone further down compared to blind girls. In this paper we have explained the reasons, why it is so? For the comparison sake we were very careful to select sighted and blind girls from the same geographical region, socio-economical and education status and food habits. Taking into consideration, our earlier hypothesis, “blind women and breast cancer”, here also we propose that only the photo regulatory system for hormonal axis is responsible for differential lowering of Menarcheal age in sighted and blind girls, since all other regulatory factors are same in both the groups.
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Notes Approved no
Call Number IDA @ intern @ Serial 2320
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Author Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya
Title Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya Type Journal Article
Year 2018 Publication Journal of Health, Medicine and Nursing Abbreviated Journal
Volume 56 Issue Pages
Keywords (up) Human Health
Abstract Sleep is essential for rest, repair, well-being, and survival of the patient. Sleep quality varies in critically ill patients and is measured by patient's satisfaction of the sleep experience, integrating aspects of sleep initiation, sleep maintenance, quantity of sleep and the refreshment upon awakening. Altered sleep is a common problem experienced by patients in critical care units. This alterations may lead to physiological and psychological dysfunctions that may affect recovery. Critically ill patients frequently experience poor sleep, characterized by frequent disruptions and loss of circadian rhythms. This study investigated factors influencing the quality of sleep among critically ill patients in hospitals in Western Kenya. A cross-sectional descriptive research design was used to examine these factors. A total of 142 patients above 18 years who were admitted to the Intensive Care Unit (ICU) and those transferred from the ICU to the general ward during the study period were conveniently selected for participation in the study. For triangulation, 10 nurses who worked in the ICU also participated in the study. A structured questionnaire was used to collect data from patients while a checklist was used to observe nursing interventions. Descriptive statistical techniques used were frequencies and percentages, while chi-square was used with the p-value set at 0.05 to test the association between factors and quality of sleep. The study results showed that frequent, nursing care activities 96.5% (n=137) noise from ventilator alarms 83.1% (n=118), feeling thirsty 57.7% (n= 82) and pain 52.8% (n=75) were among the major factors influencing the quality of sleep in ICU. A one-way analysis of variance (ANOVA) revealed patient factors significantly associated with quality sleep were age p=.006 and marital status p=.02, environmental factors significantly affecting sleep were presence of light at night with a p <0.0001 and noise from alarms p=.01. Physiological factors included feeling of thirst and hunger (p=0.03). This study recommends optimal use of analgesics and sedatives for pain management, adequate fluid replacement and hydration, noise reduction strategies, including minimizing monitor and ventilator alarms, reducing staff and telephone conversations and use of ear plugs for patients in ICU. Further, nurses should implement clustered procedures to reduce disruption of sleep among critically ill patients.
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Notes Approved no
Call Number IDA @ intern @ Serial 2974
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Author Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A.
Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control
Volume 25 Issue 1 Pages 1073274818812908
Keywords (up) Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED
Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.
Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1073-2748 ISBN Medium
Area Expedition Conference
Notes PMID:30477310; PMCID:PMC6259078 Approved no
Call Number IDA @ john @ Serial 2143
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Author Ouyang, J.Q.; Davies, S.; Dominoni, D.
Title Hormonally mediated effects of artificial light at night on behavior and fitness: linking endocrine mechanisms with function Type Journal Article
Year 2018 Publication The Journal of Experimental Biology Abbreviated Journal J Exp Biol
Volume 221 Issue Pt 6 Pages
Keywords (up) Human Health; Alan; Glucocorticoid; Hormones; Light pollution; Melatonin; Metabolism; Sleep; Stress; Thyroid; Urban ecology
Abstract Alternation between day and night is a predictable environmental fluctuation that organisms use to time their activities. Since the invention of artificial lighting, this predictability has been disrupted and continues to change in a unidirectional fashion with increasing urbanization. As hormones mediate individual responses to changing environments, endocrine systems might be one of the first systems affected, as well as being the first line of defense to ameliorate any negative health impacts. In this Review, we first highlight how light can influence endocrine function in vertebrates. We then focus on four endocrine axes that might be affected by artificial light at night (ALAN): pineal, reproductive, adrenal and thyroid. Throughout, we highlight key findings, rather than performing an exhaustive review, in order to emphasize knowledge gaps that are hindering progress on proposing impactful and concrete plans to ameliorate the negative effects of ALAN. We discuss these findings with respect to impacts on human and animal health, with a focus on the consequences of anthropogenic modification of the night-time environment for non-human organisms. Lastly, we stress the need for the integration of field and lab experiments as well as the need for long-term integrative eco-physiological studies in the rapidly expanding field of light pollution.
Address Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK;
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-0949 ISBN Medium
Area Expedition Conference
Notes PMID:29545373 Approved no
Call Number IDA @ john @ Serial 1817
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