| Records |
| Author |
Jan Stenvers, D.; Scheer, F.A.J.L.; Schrauwen, P.; la Fleur, S.E.; Kalsbeek, A. |
| Title |
Circadian clocks and insulin resistance |
Type |
Journal Article |
| Year |
2018 |
Publication |
Nature Reviews. Endocrinology |
Abbreviated Journal |
Nat Rev Endocrinol |
| Volume |
in press |
Issue |
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Pages |
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Keywords  |
Human Health; Review |
| Abstract |
Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. The central clock regulates food intake, energy expenditure and whole-body insulin sensitivity, and these actions are further fine-tuned by local peripheral clocks. For instance, the peripheral clock in the gut regulates glucose absorption, peripheral clocks in muscle, adipose tissue and liver regulate local insulin sensitivity, and the peripheral clock in the pancreas regulates insulin secretion. Misalignment between different components of the circadian timing system and daily rhythms of sleep-wake behaviour or food intake as a result of genetic, environmental or behavioural factors might be an important contributor to the development of insulin resistance. Specifically, clock gene mutations, exposure to artificial light-dark cycles, disturbed sleep, shift work and social jet lag are factors that might contribute to circadian disruption. Here, we review the physiological links between circadian clocks, glucose metabolism and insulin sensitivity, and present current evidence for a relationship between circadian disruption and insulin resistance. We conclude by proposing several strategies that aim to use chronobiological knowledge to improve human metabolic health. |
| Address |
Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands. a.kalsbeek@nin.knaw.nl |
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English |
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| ISSN |
1759-5029 |
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| Notes |
PMID:30531917 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
2133 |
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| Author |
Masri, S.; Sassone-Corsi, P. |
| Title |
The emerging link between cancer, metabolism, and circadian rhythms |
Type |
Journal Article |
| Year |
2018 |
Publication |
Nature Medicine |
Abbreviated Journal |
Nat Med |
| Volume |
24 |
Issue |
12 |
Pages |
1795-1803 |
| Keywords |
Human Health; Review |
| Abstract |
The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies. |
| Address |
Department of Biological Chemistry, Center for Epigenetics and Metabolism, INSERM U1233, University of California Irvine, Irvine, CA, USA. psc@uci.edu |
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English |
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1078-8956 |
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| Notes |
PMID:30523327 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
2135 |
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| Author |
Abbott, S.M.; Malkani, R.G.; Zee, P.C. |
| Title |
Circadian disruption and human health: A bidirectional relationship |
Type |
Journal Article |
| Year |
2018 |
Publication |
The European Journal of Neuroscience |
Abbreviated Journal |
Eur J Neurosci |
| Volume |
in press |
Issue |
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Pages |
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| Keywords |
Human Health; Review |
| Abstract |
Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep-wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine. |
| Address |
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois |
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English |
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0953-816X |
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| Notes |
PMID:30549337 |
Approved |
no |
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GFZ @ kyba @ |
Serial |
2154 |
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| Author |
Pilz, L.K.; Levandovski, R.; Oliveira, M.A.B.; Hidalgo, M.P.; Roenneberg, T. |
| Title |
Sleep and light exposure across different levels of urbanisation in Brazilian communities |
Type |
Journal Article |
| Year |
2018 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
| Volume |
8 |
Issue |
1 |
Pages |
11389 |
| Keywords |
Human Health; Sleep |
| Abstract |
Quilombos are settlements originally founded by Africans and African descendants (Quilombolas) in remote parts of Brazil to escape slavery. Due to individual histories, Quilombos nowadays exhibit different states of industrialisation, making them ideal for studying the influence of electrification on daily behaviour. In a comparative approach, we aimed to understand whether and how human sleep changes with the introduction of artificial light. We investigated daily rest-activity-rhythms and sleep-patterns in the Quilombolas' by both wrist actimetry and the Munich ChronoType Questionnaire (MCTQ; the results of these two instruments correlated highly). Seven communities (MCTQ: N = 213/actimetry: N = 125) were compared in this study. Light exposure, phase of activity, sleep timing and duration differ across communities with various levels of urbanisation and histories of access to electricity. People living without electricity and those, who acquired it only very recently on average sleep earlier than those in more urbanised communities (mid-sleep about 1 hour earlier); sleep duration tends to be longer. Our results and those of others show that use of electricity and modern lifestyles have changed sleep behaviour. To understand the consequences of these changes for health, further studies are warranted. |
| Address |
Visiting Professor at UFRGS/CAPES, Porto Alegre, RS, Brazil. roenneberg@lmu.de |
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English |
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2045-2322 |
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| Notes |
PMID:30061685 |
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no |
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GFZ @ kyba @ |
Serial |
1968 |
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| Author |
Mulvin, D. |
| Title |
Media Prophylaxis: Night Modes and the Politics of Preventing Harm |
Type |
Journal Article |
| Year |
2018 |
Publication |
Information & Culture |
Abbreviated Journal |
Information & Culture |
| Volume |
53 |
Issue |
2 |
Pages |
175-202 |
| Keywords |
Human Health; Society |
| Abstract |
This article develops the term “media prophylaxis” to analyze the ways technologies are applied to challenges of calibrating one’s body with its environment and as defenses against endemic, human-made harms. In recent years, self-illuminated screens (like those of computers, phones, and tablets) have been identified by scientists, journalists, and concerned individuals as particularly pernicious sources of sleep-disrupting light. By tracing the history of circadian research, the effects of light on sleep patterns, and the recent appearance of software like “f.lux,” Apple’s “Night Shift,” and “Twilight,” this article shows how media-prophylactic technologies can individualize responsibility for preventing harm while simultaneously surfacing otherwise ignored forms of chronic suffering. |
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2164-8034 |
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no |
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GFZ @ kyba @ |
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1853 |
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