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Author Taufique, S.K.T.; Prabhat, A.; Kumar, V. url  doi
openurl 
  Title Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids Type Journal Article
  Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume in press Issue Pages in press  
  Keywords Animals  
  Abstract Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 h light (150 lux): 12 h darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals. Dim light (6 lux) at night (dLAN) altered daily activity:rest pattern, reduced sleep and induced depressive-like responses (decreased eating and self-grooming, self-mutilation and reduced novel object exploration); return to an absolute dark night reversed these negative effects. dLAN suppressed nocturnal melatonin levels, however, diurnal corticosterone levels were unaffected. Concomitant reduction of immunoreactivity for DCX and BDNF suggested dLAN-induced suppression of hippocampal neurogenesis and compromised neuronal health. dLAN also negatively influenced hippocampal expression of genes associated with depressive-like responses (bdnf, il-1beta, tnfr1, nr4a2), but not of those associated with neuronal plasticity (egr1, creb, syngap, syn2, grin2a, grin2b), cellular oxidative stress (gst, sod3, cat1) and neuronal death (caspase2, caspase3, foxo3). Furthermore, we envisaged the role of BDNF and showed epigenetic modification of bdnf gene by decreased histone H3 acetylation and increased hdac4 expression under dLAN. These results demonstrate transcriptional and epigenetic bases of dLAN-induced negative effects in diurnal crows, and provide insights into the risks of exposure to illuminated nights to animals including humans in an urban setting. This article is protected by copyright. All rights reserved.  
  Address IndoUS Center for Biological Timing Department of Zoology, University of Delhi, Delhi, 110 007, India  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30218624 Approved no  
  Call Number GFZ @ kyba @ Serial 2010  
Permanent link to this record
 

 
Author Park, C.Y. url  doi
openurl 
  Title Night Light Pollution and Ocular Fatigue Type Journal Article
  Year 2018 Publication Journal of Korean Medical Science Abbreviated Journal J Korean Med Sci  
  Volume 33 Issue 38 Pages e257  
  Keywords Commentary; Human Health  
  Abstract  
  Address Department of Ophthalmology, Dongguk University, Ilsan Hospital, Goyang, Korea  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1011-8934 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30220898; PMCID:PMC6137033 Approved no  
  Call Number GFZ @ kyba @ Serial 2011  
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Author McGlashan, E.M.; Nandam, L.S.; Vidafar, P.; Mansfield, D.R.; Rajaratnam, S.M.W.; Cain, S.W. url  doi
openurl 
  Title The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose Type Journal Article
  Year 2018 Publication Psychopharmacology Abbreviated Journal Psychopharmacology (Berl)  
  Volume in press Issue Pages in press  
  Keywords Human Health  
  Abstract RATIONALE: Disturbances of the circadian system are common in depression. Though they typically subside when depression is treated with antidepressants, the mechanism by which this occurs is unknown. Despite being the most commonly prescribed class of antidepressants, the effect of selective serotonin reuptake inhibitors (SSRIs) on the human circadian clock is not well understood. OBJECTIVE: To examine the effect of the SSRI citalopram (30 mg) on the sensitivity of the human circadian system to light. METHODS: This study used a double-blind, placebo-controlled, within-subjects, crossover design. Participants completed two melatonin suppression assessments in room level light (~ 100 lx), taking either a single dose of citalopram 30 mg or a placebo at the beginning of each light exposure. Melatonin suppression was calculated by comparing placebo and citalopram light exposure conditions to a dim light baseline. RESULTS: A 47% increase in melatonin suppression was observed after administration of an acute dose of citalopram, with all participants showing more suppression after citalopram administration (large effect, d = 1.54). Further, melatonin onset occurred later under normal room light with citalopram compared to placebo. CONCLUSIONS: Increased sensitivity of the circadian system to light could assist in explaining some of the inter-individual variability in antidepressant treatment responses, as it is likely to assist in recovery in some patients, while causing further disruption for others.  
  Address Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. sean.cain@monash.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0033-3158 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30219986 Approved no  
  Call Number GFZ @ kyba @ Serial 2012  
Permanent link to this record
 

 
Author Zeale, M.R.K.; Stone, E.L.; Zeale, E.; Browne, W.J.; Harris, S.; Jones, G. url  doi
openurl 
  Title Experimentally manipulating light spectra reveals the importance of dark corridors for commuting bats Type Journal Article
  Year 2018 Publication Global Change Biology Abbreviated Journal Glob Chang Biol  
  Volume in press Issue Pages in press  
  Keywords Animals  
  Abstract The rapid global spread of artificial light at night is causing unprecedented disruption to ecosystems. In otherwise dark environments, street lights restrict the use of major flight routes by some bats, including the threatened lesser horseshoe bat Rhinolophus hipposideros, and may disrupt foraging. Using radio tracking, we examined the response of individual female R. hipposideros to experimental street lights placed on hedgerows used as major flight routes. Hedgerows were illuminated on one side over four nights using lights with different emission spectra, while the opposite side of the hedge was not illuminated. Automated bat detectors were used to examine changes in overall bat activity by R. hipposideros and other bat species present. R. hipposideros activity reduced significantly under all light types, including red light, challenging a previously held assumption that red light is safe for bats. Despite this, R. hipposideros rapidly adapted to the presence of lights by switching their flight paths to the dark side of the hedgerow, enabling them to reach foraging sites without restriction. Red light had no effect on the activity of the other species present. Slow-flying Myotis spp. avoided orange, white and green light, while more agile Pipistrellus spp. were significantly more abundant at these light types compared to dark controls, most probably in response to accumulations of insect prey. No effect of any light type was found for Nyctalus or Eptesicus spp. Our findings demonstrate that caution must be used when promoting forms of lighting that are thought to be safe for wildlife before they are tested more widely. We argue that it is essential to preserve dark corridors free from light pollution to mitigate the impacts of artificial light at night on bat activity and movements. This article is protected by copyright. All rights reserved.  
  Address School of Biological Sciences, Life Sciences Building, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1354-1013 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30288876 Approved no  
  Call Number GFZ @ kyba @ Serial 2021  
Permanent link to this record
 

 
Author Taufique, S.T.; Prabhat, A.; Kumar, V. url  doi
openurl 
  Title Light at night affects hippocampal and nidopallial cytoarchitecture: Implication for impairment of brain function in diurnal corvids Type Journal Article
  Year 2018 Publication Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology Abbreviated Journal J Exp Zool A Ecol Integr Physiol  
  Volume in press Issue Pages in press  
  Keywords Animals  
  Abstract Our previous studies have shown that light at night (LAN) impaired cognitive performance and affected neurogenesis and neurochemistry in the cognition-associated brain regions, particularly the hippocampus (HP) and lateral caudal nidopallium (NCL) of Indian house crows (Corvus splendens). Here, we examined the cytoarchitecture and mapped out the morphology of neurons and glia-neuron density in HP and NCL regions of crows that were first entrained to 12-hr light (LL): 12-hr darkness (LD) and then exposed to the light regime in which 12-hr darkness was either replaced by daytime light (i.e., constant light, LL) or by dim light (i.e., dim light at night, dLAN), with controls continued on LD 12:12. Compared with LD, there was a significant decrease in the soma size, suggesting reduced neuronal plasticity without affecting the neuronal density of both HP and NCL of crows under LL and dLAN conditions. In parallel, we found a reduced number of glia cells and, hence, decreased glia-neuron ratio positively correlated with soma size in both, HP and NCL regions. These results for the first time demonstrate LAN-induced negative effects on the brain cytoarchitecture of a diurnal species and give insight for possible influence on the brain health and functions in animals including humans that might be inadvertently exposed to LAN in an emerging night-illuminated urban environment.  
  Address Department of Zoology, University of Delhi, Delhi, India  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2471-5638 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30288960 Approved no  
  Call Number GFZ @ kyba @ Serial 2022  
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