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Author Chen, Y.; Cheng, M.; Su, T.; Gao, T.; Yu, W. url  doi
openurl 
  Title Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats Type Journal Article
  Year 2018 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume in press Issue Pages  
  Keywords Animals  
  Abstract Constant light exposure is widespread in the intensive care unit (ICU) and could increase the rate of brain dysfunction as delirium and sleep disorders in critical patients. And the activation of hypothalamic neuropeptides is proved to play a crucial role in regulating hypercatabolism, especially skeletal muscle wasting in critical patients, which could lead to serious complications and poor prognosis. Here we investigated the hypothesis that constant light exposure could aggravate skeletal muscle wasting in endotoxemia rats and whether it was associated with alterations of circadian clock and hypothalamic proopiomelanocortin(POMC) expression. Fifty-four adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide(LPS) or saline, subjected to constant light or a 12:12h light-dark cycle for 7 days. On day 8, rats were sacrificed across six time points in 24h and hypothalamus tissues and skeletal muscle were obtained. Rates of muscle wasting were measured by 3-methylhistidine(3-MH) and tyrosine release as well as expression of two muscle atrophic genes, muscle ring finger 1(MuRF-1) and muscle atrophy F-box(MAFbx). The expression of circadian clock genes, silent information regulator 1(SIRT1), POMC and hypothalamic inflammatory cytokines were also detected. Results showed that LPS administration significantly increased hypothalamic POMC expression, inflammatory cytokine levels and muscle wasting rates. Meanwhile constant light exposure disrupted the circadian rhythm, declined the expression of SIRT1 as well as aggravated hypothalamic POMC overexpression and skeletal muscle wasting in rats with endotoxemia. Taken together, the results demonstrated that constant light exposure could aggravate POMC-mediated skeletal muscle wasting in endotoxemia rats, which is associated with alteration of circadian clocks and SIRT1 in the hypothalamus.  
  Address Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: yudrnj2@163.com  
  Corporate Author Thesis  
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  Language (down) English Summary Language Original Title  
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  ISSN 0006-291X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30528733 Approved no  
  Call Number GFZ @ kyba @ Serial 2134  
Permanent link to this record
 

 
Author Masri, S.; Sassone-Corsi, P. url  doi
openurl 
  Title The emerging link between cancer, metabolism, and circadian rhythms Type Journal Article
  Year 2018 Publication Nature Medicine Abbreviated Journal Nat Med  
  Volume 24 Issue 12 Pages 1795-1803  
  Keywords Human Health; Review  
  Abstract The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.  
  Address Department of Biological Chemistry, Center for Epigenetics and Metabolism, INSERM U1233, University of California Irvine, Irvine, CA, USA. psc@uci.edu  
  Corporate Author Thesis  
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  Language (down) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1078-8956 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30523327 Approved no  
  Call Number GFZ @ kyba @ Serial 2135  
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Author Halfwerk, W.; Blaas, M.; Kramer, L.; Hijner, N.; Trillo, P.A.; Bernal, X.E.; Page, R.A.; Goutte, S.; Ryan, M.J.; Ellers, J. url  doi
openurl 
  Title Adaptive changes in sexual signalling in response to urbanization Type Journal Article
  Year 2018 Publication Nature Ecology & Evolution Abbreviated Journal Nat Ecol Evol  
  Volume 3 Issue Pages 374-380  
  Keywords Animals  
  Abstract Urbanization can cause species to adjust their sexual displays, because the effectiveness of mating signals is influenced by environmental conditions. Despite many examples that show that mating signals in urban conditions differ from those in rural conditions, we do not know whether these differences provide a combined reproductive and survival benefit to the urban phenotype. Here we show that male tungara frogs have increased the conspicuousness of their calls, which is under strong sexual and natural selection by signal receivers, as an adaptive response to city life. The urban phenotype consequently attracts more females than the forest phenotype, while avoiding the costs that are imposed by eavesdropping bats and midges, which we show are rare in urban areas. Finally, we show in a translocation experiment that urban frogs can reduce risk of predation and parasitism when moved to the forest, but that forest frogs do not increase their sexual attractiveness when moved to the city. Our findings thus reveal that urbanization can rapidly drive adaptive signal change via changes in both natural and sexual selection pressures.  
  Address Department of Ecological Science, Vrije Universiteit, Amsterdam, The Netherlands  
  Corporate Author Thesis  
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  Series Volume Series Issue Edition  
  ISSN 2397-334X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30532046 Approved no  
  Call Number GFZ @ kyba @ Serial 2136  
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Author Zerbini, G.; Kantermann, T.; Merrow, M. url  doi
openurl 
  Title Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin Type Journal Article
  Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract The timing of sleep is under the control of the circadian clock, which uses light to entrain to the external light-dark cycle. A combination of genetic, physiological and environmental factors produces individual differences in chronotype (entrained phase as manifest in sleep timing). A mismatch between circadian and societal (e.g., work) clocks leads to a condition called social jetlag, which is characterized by changing sleep times over work and free days and accumulation of sleep debt. Social jetlag, which is prevalent in late chronotypes, has been related to several health issues. One way to reduce social jetlag would be to advance the circadian clock via modifications of the light environment. We thus performed two intervention field studies to describe methods for decreasing social jetlag. One study decreased evening light exposure (via blue-light-blocking glasses) and the other used increased morning light (via the use of curtains). We measured behaviour as well as melatonin; the latter in order to validate that behaviour was consistent with this neuroendocrinological phase marker of the circadian clock. We found that a decrease in evening blue light exposure led to an advance in melatonin and sleep onset on workdays. Increased morning light exposure advanced neither melatonin secretion nor sleep timing. Neither protocol led to a significant change in social jetlag. Despite this, our findings show that controlling light exposure at home can be effective in advancing melatonin secretion and sleep, thereby helping late chronotypes to better cope with early social schedules.  
  Address Institute of Medical Psychology, LMU Munich, Munich, Germany  
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  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30506899 Approved no  
  Call Number GFZ @ kyba @ Serial 2138  
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Author Czaczkes, T.J.; Bastidas-Urrutia, A.M.; Ghislandi, P.; Tuni, C. url  doi
openurl 
  Title Reduced light avoidance in spiders from populations in light-polluted urban environments Type Journal Article
  Year 2018 Publication Die Naturwissenschaften Abbreviated Journal Naturwissenschaften  
  Volume 105 Issue 11-12 Pages 64  
  Keywords Animals  
  Abstract Increased urbanisation is leading to a rise in light pollution. Light pollution can disrupt the behaviour and physiology of animals resulting in increased mortality. However, animals may also benefit from artificial light sources, as these may aggregate prey or signal suitable environments. For example, spiders are commonly seen congregating around artificial light sources. Changes in selective pressures engendered by urban environments are driving changes in urban organisms, driving better adaptation to these environments. Here, we ask whether urban populations of the synanthropic spider Steatoda triangulosa show different responses to light compared to rural populations. Egg-sacs from urban and rural populations were collected and incubated in a common garden setting, and the emerging spiderlings tested for light preference. While rural spiderlings avoided light (37% built webs in the light), urban spiderlings were indifferent to it (49% built webs in the light). Reduced light avoidance may benefit spiders through increased prey capture, increased movement into suitable habitats, or due to a release from selection pressure from visually hunting predators which do not enter buildings.  
  Address Department of Biology, Ludwig-Maximilians University of Munich, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany  
  Corporate Author Thesis  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-1042 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30377809 Approved no  
  Call Number GFZ @ kyba @ Serial 2140  
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