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Author El-Bakry, H.A.; Ismail, I.A.; Soliman, S.S.
Title Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways Type Journal Article
Year 2018 Publication Journal of Photochemistry and Photobiology. B, Biology Abbreviated Journal J Photochem Photobiol B
Volume 186 Issue Pages 69-80
Keywords Animals
Abstract The awareness of the interrelationship between immunosenescence and constant light exposure can provide new insights into the consequences of excessive exposure to light at night due to light pollution or shift work. Here, we investigated whether constant light exposure (LL) acts as an inducer of immunosenescence. We also determined the role of melatonin or turmeric in reversing the putative effects of constant light and explored for the first time the underlying molecular mechanisms. Young (3-4-month-old) rats were exposed daily to LL alone or in combination with each of melatonin and turmeric for 12weeks. A group of aged rats (18-months old; n=6) was used as a reference for natural immunosenescence. Constant light exposure resulted in remarkable pathophysiological alterations resembling those noticed in normal aged rats, manifested as apparent decreases in antioxidant activities as well as Nrf2 and DJ-1 expressions, striking augmentation in oxidative stress, proinflammatory cytokines and expression of TNFalpha, Bax, and p53 genes, and deleterious changes of lymphoid organs, Co-administration of melatonin or turmeric was able to reverse all alterations induced by LL through upregulation of Nrf2/DJ-1 and downregulation of p53/Bax pathways. These data suggest that LL accelerates immunosenescence via oxidative stress and apoptotic pathways. They also demonstrate for the first time that turmeric is comparable to melatonin in boosting the immune function and counteracting the LL-associated immunosenescence. These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence. However, to validate the effects of turmeric on humans further studies are warranted.
Address Department of Zoology & Entomology, Faculty of Science, Minia University, Egypt
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1011-1344 ISBN Medium
Area Expedition Conference
Notes (down) PMID:30015062 Approved no
Call Number GFZ @ kyba @ Serial 1984
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Author Lu, Y.; Coops, N.C.
Title Bright lights, big city: Causal effects of population and GDP on urban brightness Type Journal Article
Year 2018 Publication PloS one Abbreviated Journal PLoS One
Volume 13 Issue 7 Pages e0199545
Keywords Remote Sensing
Abstract Cities are arguably both the cause, and answer, to societies' current sustainability issues. Urbanization is the interplay between a city's physical growth and its socio-economic development, both of which consume a substantial amount of energy and resources. Knowledge of the underlying driver(s) of urban expansion facilitates not only academic research but, more importantly, bridges the gap between science, policy drafting, and practical urban management. An increasing number of researchers are recognizing the benefits of innovative remotely sensed datasets, such as nighttime lights data (NTL), as a proxy to map urbanization and subsequently examine the driving socio-economic variables in cities. We further these approaches, by taking a trans-pacific view, and examine how an array of socio-economic ind0icators of 25 culturally and economically important urban hubs relate to long term patterns in NTL for the past 21 years. We undertake a classic econometric approach-panel causality tests which allow analysis of the causal relationships between NTL and socio-economic development across the region. The panel causality test results show a contrasting effect of population and gross domestic product (GDP) on NTL in fast, and slowly, changing cities. Information derived from this study quantitatively chronicles urban activities in the pan-Pacific region and potentially offers data for studies that spatially track local progress of sustainable urban development goals.
Address Integrated Remote Sensing Studio, Forest Recourses Management, University of British Columbia, Vancouver, BC, Canada
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1932-6203 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29995923 Approved no
Call Number GFZ @ kyba @ Serial 1963
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Author Souman, J.L.; Borra, T.; de Goijer, I.; Schlangen, L.J.M.; Vlaskamp, B.N.S.; Lucassen, M.P.
Title Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature Type Journal Article
Year 2018 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume 33 Issue 4 Pages 420-431
Keywords Human Health; Lighting
Abstract Studies with monochromatic light stimuli have shown that the action spectrum for melatonin suppression exhibits its highest sensitivity at short wavelengths, around 460 to 480 nm. Other studies have demonstrated that filtering out the short wavelengths from white light reduces melatonin suppression. However, this filtering of short wavelengths was generally confounded with reduced light intensity and/or changes in color temperature. Moreover, it changed the appearance from white light to yellow/orange, rendering it unusable for many practical applications. Here, we show that selectively tuning a polychromatic white light spectrum, compensating for the reduction in spectral power between 450 and 500 nm by enhancing power at even shorter wavelengths, can produce greatly different effects on melatonin production, without changes in illuminance or color temperature. On different evenings, 15 participants were exposed to 3 h of white light with either low or high power between 450 and 500 nm, and the effects on salivary melatonin levels and alertness were compared with those during a dim light baseline. Exposure to the spectrum with low power between 450 and 500 nm, but high power at even shorter wavelengths, did not suppress melatonin compared with dim light, despite a large difference in illuminance (175 vs. <5 lux). In contrast, exposure to the spectrum with high power between 450 and 500 nm (also 175 lux) resulted in almost 50% melatonin suppression. For alertness, no significant differences between the 3 conditions were observed. These results open up new opportunities for lighting applications that allow for the use of electrical lighting without disturbance of melatonin production.
Address Philips Lighting Research, Department Lighting Applications, Eindhoven, The Netherlands
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29984614 Approved no
Call Number GFZ @ kyba @ Serial 1985
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Author Wittenbrink, N.; Ananthasubramaniam, B.; Munch, M.; Koller, B.; Maier, B.; Weschke, C.; Bes, F.; de Zeeuw, J.; Nowozin, C.; Wahnschaffe, A.; Wisniewski, S.; Zaleska, M.; Bartok, O.; Ashwal-Fluss, R.; Lammert, H.; Herzel, H.; Hummel, M.; Kadener, S.; Kunz, D.; Kramer, A.
Title High-accuracy determination of internal circadian time from a single blood sample Type Journal Article
Year 2018 Publication The Journal of Clinical Investigation Abbreviated Journal J Clin Invest
Volume 128 Issue 9 Pages 3826-3839
Keywords Human Health
Abstract BACKGROUND: The circadian clock is a fundamental and pervasive biological program that coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to health. Whereas therapy adapted to time of day is increasingly reported to be highly successful, it needs to be personalized, since internal circadian time is different for each individual. In addition, internal time is not a stable trait, but is influenced by many factors, including genetic predisposition, age, sex, environmental light levels, and season. An easy and convenient diagnostic tool is currently missing. METHODS: To establish a validated test, we followed a 3-stage biomarker development strategy: (a) using circadian transcriptomics of blood monocytes from 12 individuals in a constant routine protocol combined with machine learning approaches, we identified biomarkers for internal time; and these biomarkers (b) were migrated to a clinically relevant gene expression profiling platform (NanoString) and (c) were externally validated using an independent study with 28 early or late chronotypes. RESULTS: We developed a highly accurate and simple assay (BodyTime) to estimate the internal circadian time in humans from a single blood sample. Our assay needs only a small set of blood-based transcript biomarkers and is as accurate as the current gold standard method, dim-light melatonin onset, at smaller monetary, time, and sample-number cost. CONCLUSION: The BodyTime assay provides a new diagnostic tool for personalization of health care according to the patient's circadian clock. FUNDING: This study was supported by the Bundesministerium fur Bildung und Forschung, Germany (FKZ: 13N13160 and 13N13162) and Intellux GmbH, Germany.
Address Charite Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Laboratory of Chronobiology, Berlin, Germany
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0021-9738 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29953415; PMCID:PMC6118629 Approved no
Call Number GFZ @ kyba @ Serial 2194
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Author Maroni, M.J.; Capri, K.M.; Cushman, A.V.; Monteiro De Pina, I.K.; Chasse, M.H.; Seggio, J.A.
Title Constant light alters serum hormone levels related to thyroid function in male CD-1 mice Type Journal Article
Year 2018 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume 35 Issue 10 Pages 1456-1463
Keywords Animals
Abstract Disruptions to the circadian rhythm can lead to altered metabolism. Modification of thyroid function may be a reason why circadian misalignment may contribute to future metabolic disorders. We investigated whether circadian disruption through constant light (LL) can lead to variations in hormone levels associated with thyroid function. Mice were exposed to LL or a 12:12 Light:Dark (LD) cycle for 6 weeks; then glucose tolerance and thyroid hormone levels were measured at ZT 6 and ZT 18. There was day/night variation in glucose tolerance, but LL had no effect. LL reduced TSH, increased fT4, and abolished day/night variation in fT3 and leptin. These findings illustrate that LL alters thyroid-related hormones, providing evidence of a link between circadian disruption and thyroid function.
Address a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29953263 Approved no
Call Number GFZ @ kyba @ Serial 1958
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