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Author Borck, P.C.; Batista, T.M.; Vettorazzi, J.F.; Soares, G.M.; Lubaczeuski, C.; Guan, D.; Boschero, A.C.; Vieira, E.; Lazar, M.A.; Carneiro, E.M.
Title Nighttime light exposure enhances Rev-erbalpha-targeting microRNAs and contributes to hepatic steatosis Type Journal Article
Year 2018 Publication Metabolism: Clinical and Experimental Abbreviated Journal Metabolism
Volume 85 Issue Pages 250-258
Keywords Animals
Abstract OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbalpha and up-regulation of its lipogenic targets ACL and FAS in liver. Furthermore, the expression of Rev-erbalpha-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group. Consistently, overexpression of these miRNAs in primary hepatocytes reduced Rev-erbalpha expression at the mRNA and protein levels. Importantly, overexpression of Rev-erbalpha-targeting miRNAs increased mRNA levels of Acly and Fasn. CONCLUSION: Thus, altered miRNA profile is an important mechanism underlying the disruption of the peripheral clock caused by exposure to ALAN, which could lead to hepatic steatosis.
Address Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0026-0495 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29751019 Approved no
Call Number GFZ @ kyba @ Serial 1891
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Author Nelson, R.J.; Chbeir, S.
Title Dark matters: effects of light at night on metabolism Type Journal Article
Year 2018 Publication The Proceedings of the Nutrition Society Abbreviated Journal Proc Nutr Soc
Volume 77 Issue 3 Pages 223-229
Keywords Human Health
Abstract Life on earth has evolved during the past several billion years under relatively bright days and dark night conditions. The wide-spread adoption of electric lights during the past century exposed animals, both human and non-human, to significant light at night for the first time in their evolutionary history. Endogenous circadian clocks depend on light to entrain to the external daily environment and seasonal rhythms depend on clear nightly melatonin signals to assess time of year. Thus, light at night can derange temporal adaptations. Indeed, disruption of naturally evolved light-dark cycles results in several physiological and behavioural changes with potentially serious implications for physiology, behaviour and mood. In this review, data from night-shift workers on their elevated risk for metabolic disorders, as well as data from animal studies will be discussed. Night-shift workers are predisposed to obesity and dysregulated metabolism that may result from disrupted circadian rhythms. Although studies in human subjects are correlative, animal studies have revealed several mechanisms through which light at night may exert its effects on metabolism by disrupting circadian rhythms that are associated with inflammation, both in the brain and in the periphery. Disruption of the typical timing of food intake is a key effect of light at night and subsequent metabolic dysregulation. Strategies to avoid the effects of light at night on body mass dysregulation should be pursued.
Address Department of Neuroscience,The Ohio State University,Columbus, OH 43210,USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0029-6651 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29747703 Approved no
Call Number GFZ @ kyba @ Serial 1896
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Author McKenna, H.; van der Horst, G.T.J.; Reiss, I.; Martin, D.
Title Clinical chronobiology: a timely consideration in critical care medicine Type Journal Article
Year 2018 Publication Critical Care (London, England) Abbreviated Journal Crit Care
Volume 22 Issue 1 Pages 124
Keywords Human Health; Review
Abstract A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature conserved across most life on Earth. Organisms compartmentalise processes with respect to time in order to promote survival, in a manner that mirrors the rotation of the planet and accompanying diurnal cycles of light and darkness. The influence of circadian rhythms can no longer be overlooked in clinical settings; this review provides intensivists with an up-to-date understanding of the burgeoning field of chronobiology, and suggests ways to incorporate these concepts into daily practice to improve patient outcomes. We outline the function of molecular clocks in remote tissues, which adjust cellular and global physiological function according to the time of day, and the potential clinical advantages to keeping in time with them. We highlight the consequences of “chronopathology”, when this harmony is lost, and the risk factors for this condition in critically ill patients. We introduce the concept of “chronofitness” as a new target in the treatment of critical illness: preserving the internal synchronisation of clocks in different tissues, as well as external synchronisation with the environment. We describe methods for monitoring circadian rhythms in a clinical setting, and how this technology may be used for identifying optimal time windows for interventions, or to alert the physician to a critical deterioration of circadian rhythmicity. We suggest a chronobiological approach to critical illness, involving multicomponent strategies to promote chronofitness (chronobundles), and further investment in the development of personalised, time-based treatment for critically ill patients.
Address Critical Care Unit, Royal Free Hospital, Pond Street, London, NW3 2QG, UK. daniel.martin@ucl.ac.uk
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1364-8535 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29747699 Approved no
Call Number GFZ @ kyba @ Serial 1897
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Author Gaydecki, P.
Title Automated moth flight analysis in the vicinity of artificial light Type Journal Article
Year 2018 Publication Bulletin of Entomological Research Abbreviated Journal Bull Entomol Res
Volume 109 Issue 1 Pages 127-140
Keywords Instrumentation; Animals
Abstract Instrumentation and software for the automated analysis of insect flight trajectories is described, intended for quantifying the behavioural dynamics of moths in the vicinity of artificial light. For its time, this moth imaging system was relatively advanced and revealed hitherto undocumented insights into moth flight behaviour. The illumination source comprised a 125 W mercury vapour light, operating in the visible and near ultraviolet wavelengths, mounted on top of a mobile telescopic mast at heights of 5 and 7.1 m, depending upon the experiment. Moths were imaged in early September, at night and in field conditions, using a ground level video camera with associated optics including a heated steering mirror, wide angle lens and an electronic image intensifier. Moth flight coordinates were recorded at a rate of 50 images per second (fields) and transferred to a computer using a light pen (the only non-automated operation in the processing sequence). Software extracted ground speed vectors and, by instantaneous subtraction of wind speed data supplied by fast-response anemometers, the airspeed vectors. Accumulated density profiles of the track data revealed that moths spend most of their time at a radius of between 40 and 50 cm from the source, and rarely fly directly above it, from close range. Furthermore, the proportion of insects caught by the trap as a proportion of the number influenced by the light (and within the field of view of the camera) was very low; of 1600 individual tracks recorded over five nights, a total of only 12 were caught. Although trap efficiency is strongly dependent on trap height, time of night, season, moonlight and weather, the data analysis confirmed that moths do not exhibit straightforward positive phototaxis. In general, trajectory patterns become more complex with reduced distance from the illumination, with higher recorded values of speeds and angular velocities. However, these characteristics are further qualified by the direction of travel of the insect; the highest accelerations tended to occur when the insect was at close range, but moving away from the source. Rather than manifesting a simple positive phototaxis, the trajectories were suggestive of disorientation. Based on the data and the complex behavioural response, mathematical models were developed that described ideal density distribution in calm air and light wind speed conditions. The models did not offer a physiological hypothesis regarding the behavioural changes, but rather were tools for quantification and prediction. Since the time that the system was developed, instrumentation, computers and software have advanced considerably, allowing much more to be achieved at a small fraction of the original cost. Nevertheless, the analytical tools remain useful for automated trajectory analysis of airborne insects.
Address School of Electrical and Electronic Engineering, University of Manchester,Manchester M13 9PL,UK
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-4853 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29745349 Approved no
Call Number GFZ @ kyba @ Serial 1895
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Author McLay, L.K.; Nagarajan-Radha, V.; Green, M.P.; Jones, T.M.
Title Dim artificial light at night affects mating, reproductive output, and reactive oxygen species in Drosophila melanogaster Type Journal Article
Year 2018 Publication Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology Abbreviated Journal J Exp Zool A Ecol Integr Physiol
Volume 329 Issue 8-9 Pages 419-428
Keywords Animals
Abstract Humans are lighting the night-time environment with ever increasing extent and intensity, resulting in a variety of negative ecological effects in individuals and populations. Effects of light at night on reproductive fitness traits are demonstrated across taxa however, the mechanisms underlying these effects are largely untested. One possible mechanism is that light at night may result in perturbed reactive oxygen species (ROS) and oxidative stress levels. Here, we reared Drosophila melanogaster under either dim (10 lx) light or no light (0 lx) at night for three generations and then compared mating and lifetime oviposition patterns. In a second experiment, we explored whether exposure to light at night treatments resulted in variation in ROS levels in the heads and ovaries of six, 23- and 36-day-old females. We demonstrate that dim light at night affects mating and reproductive output: 10 lx flies courted for longer prior to mating, and female oviposition patterns differed to 0 lx females. ROS levels were lower in the ovaries but not heads, of 10 lx compared with 0 lx females. We suggest that reduced ROS levels may reflect changes in ovarian physiology and cell signaling, which may be related to the differences observed in oviposition patterns. Taken together, our results indicate negative consequences for invertebrates under more stressful, urban, lit conditions and further investigation into the mechanisms driving these changes is warranted to manage invertebrate communities in a brighter future.
Address School of BioSciences, Faculty of Science, The University of Melbourne, Melbourne, Victoria, Australia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2471-5638 ISBN Medium
Area Expedition Conference
Notes (down) PMID:29733537 Approved no
Call Number GFZ @ kyba @ Serial 1889
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