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Author Souman, J.L.; Tinga, A.M.; Te Pas, S.F.; van Ee, R.; Vlaskamp, B.N.S.
Title Acute alerting effects of light: a systematic literature review Type Journal Article
Year 2018 Publication Behavioural Brain Research Abbreviated Journal Behav Brain Res
Volume 337 Issue Pages 228-239
Keywords Human Health
Abstract Periodic, well timed exposure to light is important for our health and wellbeing. Light, in particular in the blue part of the spectrum, is thought to affect alertness both indirectly, by modifying circadian rhythms, and directly, giving rise to acute effects. We performed a systematic review of empirical studies on direct, acute effects of light on alertness to evaluate the reliability of these effects and to assess to what extent they depend on other factors, such as time of day, exposure duration and sleep pressure. In total, we identified 74 studies in which either light intensity, spectral distribution, or both were manipulated, and the effects on behavioral measures of alertness were evaluated, either subjectively or measured in performance tasks. The results show that increasing the intensity or the color temperature of polychromatic white light in general has been found to increase subjective ratings of alertness, though a substantial proportion of these studies failed to find significant effects. There is little evidence in the literature that these subjective alerting effects of light also translate into improvements on performance measures of alertness. For monochromatic or narrowband light exposure, some studies have shown improvement in reaction time tasks with exposure to blue light, but generally this was not accompanied by changes in subjective alertness. Thus, the alerting effects of light are far less clear than often suggested. We suggest that in future studies more attention should be paid to other factors that may influence the effects of light, such as chronotype, circadian phase, homeostatic state and prior light history.
Address Philips Research (Department Brain, Behavior & Cognition), Eindhoven, The Netherlands
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0166-4328 ISBN Medium
Area Expedition Conference
Notes (up) PMID:28912014 Approved no
Call Number LoNNe @ kyba @ Serial 1727
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Author Hall, A.L.; Davies, H.W.; Koehoorn, M.
Title Personal light-at-night exposures and components of variability in two common shift work industries: uses and implications for future research Type Journal Article
Year 2018 Publication Scandinavian Journal of Work, Environment & Health Abbreviated Journal Scand J Work Environ Health
Volume 44 Issue 1 Pages 80-87
Keywords Human Health
Abstract Objectives Shift workers' increased risk of various adverse health outcomes has been linked to light-at-night (LAN) exposure, but few studies have measured LAN exposure in workplaces. To inform future research methods, this study aimed to (i) measure shift workers' exposures to LAN across industries, occupations, and work environments and (ii) assess components of variance across different exposure groupings and metrics. Methods Between October 2015 and March 2016, 152 personal full-shift measurements were collected from 102 night shift workers in emergency health services (paramedics, dispatchers) and healthcare industries (nurses, care aides, security guards, unit clerks, and laboratory, pharmacy, and respiratory therapy staff) in the province of British Columbia, Canada. Descriptive and variance component analyses were conducted for the 23:00-05:00 period to characterize exposures using multiple metrics of potential biological relevance (median lux, 90 thpercentile lux, sum of minutes >/=30 lux, and sum of minutes >/=100 lux). Results Average exposure levels were highest in the healthcare industry. By occupation, laboratory workers and care aides displayed the highest and emergency dispatch officers displayed the lowest levels for all LAN exposure metrics. Between-group variance was large relative to within-group variance for all exposure groupings and metrics, and increased as grouping specificity increased (moving from industry to occupation). Conclusions Results from this study suggest that high-level grouping schemes may provide a simple yet effective way of characterizing individual LAN exposures in epidemiological studies of shift work. Ongoing measurement of LAN exposures and assessment of exposure variability is needed in future studies of shift workers as a means to increase sampling efficiency, reduce measurement error, and maximize researchers' ability to detect relationships where they exist.
Address School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, V6T1Z3, Canada. amyhall@mail.ubc.ca
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0355-3140 ISBN Medium
Area Expedition Conference
Notes (up) PMID:28951937 Approved no
Call Number LoNNe @ kyba @ Serial 1754
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Author Boswell, W.T.; Boswell, M.; Walter, D.J.; Navarro, K.L.; Chang, J.; Lu, Y.; Savage, M.G.; Shen, J.; Walter, R.B.
Title Exposure to 4100K fluorescent light elicits sex specific transcriptional responses in Xiphophorus maculatus skin Type Journal Article
Year 2018 Publication Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP Abbreviated Journal Comp Biochem Physiol C Toxicol Pharmacol
Volume 208 Issue Pages 96-104
Keywords Animals
Abstract It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in the skin of Xiphophorus fish after exposure to ultraviolet light (UV), as well as, both broad spectrum and narrow waveband visible light. In regard to fluorescent light (FL), we have shown that male X. maculatus exposed to 4100K FL (i.e. “cool white”) rapidly suppress transcription of many genes involved with DNA replication and repair, chromosomal segregation, and cell cycle progression in skin. We have also detailed sex specific transcriptional responses of Xiphophorus skin after exposure to UVB. However, investigation of gender differences in global gene expression response after exposure to 4100K FL has not been reported, despite common use of this FL source for residential, commercial, and animal facility illumination. Here, we compare RNASeq results analyzed to assess changes in the global transcription profiles of female and male X. maculatus skin in response to 4100K FL exposure. Our results suggest 4100K FL exposure incites a sex-biased genetic response including up-modulation of inflammation in females and down modulation of DNA repair/replication in males. In addition, we identify clusters of genes that become oppositely modulated in males and females after FL exposure that are principally involved in cell death and cell proliferation.
Address Department of Chemistry and Biochemistry, Xiphophorus Genetic Stock Center, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Electronic address: RW12@txstate.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1532-0456 ISBN Medium
Area Expedition Conference
Notes (up) PMID:28965926 Approved no
Call Number LoNNe @ kyba @ Serial 1739
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Author Gonzalez, T.J.; Lu, Y.; Boswell, M.; Boswell, W.; Medrano, G.; Walter, S.; Ellis, S.; Savage, M.; Varga, Z.M.; Lawrence, C.; Sanders, G.; Walter, R.B.
Title Fluorescent light exposure incites acute and prolonged immune responses in Zebrafish (Danio rerio) skin Type Journal Article
Year 2018 Publication Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP Abbreviated Journal Comp Biochem Physiol C Toxicol Pharmacol
Volume 208 Issue Pages 87-95
Keywords Animals
Abstract Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure. Previous studies showed that one of the commonly used fluorescent light source (FL; 4100K or “cool white”) can affect signaling pathways related to maintenance of circadian rhythm, cell cycle progression, chromosome segregation, and DNA repair/recombination in the skin of male Xiphophorus maculatus. These observations raise questions concerning the kinetics of the FL induced gene expression response, and which biological functions become modulated at various times after light exposure. To address these questions, we exposed zebrafish to 4100K FL and utilized RNASeq to assess gene expression changes in skin at various times (1 to 12h) after FL exposure. We found 4100K FL incites a robust early (1-2h) transcriptional response, followed by a more protracted late response (i.e., 4-12h). The early transcriptional response involves genes associated with cell migration/infiltration and cell proliferation as part of an overall increase in immune function and inflammation. The protracted late transcriptional response occurs within gene sets predicted to maintain and perpetuate the inflammatory response, as well as suppression of lipid, xenobiotic, and melatonin metabolism.
Address Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, 419 Centennial Hall, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Electronic address: RWalter@txstate.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1532-0456 ISBN Medium
Area Expedition Conference
Notes (up) PMID:28965927 Approved no
Call Number LoNNe @ kyba @ Serial 1740
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Author Obayashi, K.; Saeki, K.; Kurumatani, N.
Title Bedroom Light Exposure at Night and the Incidence of Depressive Symptoms: A Longitudinal Study of the HEIJO-KYO Cohort Type Journal Article
Year 2018 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol
Volume 187 Issue 3 Pages 427-434
Keywords Human Health; Mental Health; indoor light; geriatrics; Sleep; Sleep Disorders
Abstract Previous studies have indicated that minimal exposure to light at night (LAN) increases depression risk, even at 5 lux, in nocturnal and diurnal mammals. Although such low-level LAN may affect human circadian physiology, the association between exposure to LAN and depressive symptoms remains uncertain. In the present study, bedroom light intensity was measured objectively, and depressive symptoms were assessed, during 2010-2014 in Nara, Japan. Of 863 participants (mean age = 71.5 years) who did not have depressive symptoms at baseline, 73 participants reported development of depressive symptoms during follow-up (median, 24 months). Compared with the “dark” group (average of <5 lux; n = 710), the LAN group (average of >/=5 lux; n = 153) exhibited a significantly higher depression risk (hazard ratio = 1.89; 95% CI: 1.13, 3.14), according to a Cox proportional hazards model adjusting for age, sex, body mass index, and economic status. Further, the significance remained in a multivariable model adjusting for hypertension, diabetes, and sleep parameters (hazard ratio = 1.72; 95% CI: 1.03, 2.89). Sensitivity analyses using bedroom light data with a cutoff value of >/=10 lux suggested consistent results. In conclusion, these results indicated that exposure to LAN in home settings was independently associated with subsequent depression risk in an elderly general population.
Address Department of Community Health and Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashiharashi, Nara 634-8521, Japan; e-mail: obayashi(at)naramed-u.ac.jp
Corporate Author Thesis
Publisher Oxford Academic Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0002-9262 ISBN Medium
Area Expedition Conference
Notes (up) PMID:28992236 Approved no
Call Number IDA @ john @ Serial 1815
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