| Records |
| Author |
Ma, Q.; Tan, Y.; Chen, X.; Chen, S.; Sun, Y.; Zhou, B. |
| Title |
Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution |
Type |
Journal Article |
| Year |
2018 |
Publication  |
International Journal of Molecular Medicine |
Abbreviated Journal |
Int J Mol Med |
| Volume |
in press |
Issue |
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Pages |
in press |
| Keywords |
Animals |
| Abstract |
The present study aimed to explore the difference in the expression profiles of ovarian microRNA sequences in rats in a light pollution environment and rats in a normal light environment. Rats in the control group were exposed to 12h light/dark cycles, while rats in the model group were continuously exposed to 24h light. The ovaries were extracted from the two groups of rats, and Illumina HiSeq 2500 highthroughput sequencing technology was used to detect the differences in microRNA (miRNA) expression among the two groups. Fluorescence quantitative reverse transcriptionpolymerase chain reaction was used to verify the differential expression of miRNA. The present study was designed to experimentally validate the interaction between miR4215p and mitogenactivated protein kinase (MAPK) 7 by using the dualluciferase reporter system, and to explore the expression of proteins in the MAPK signaling pathway with a lentiviral vectormediated small hairpin RNA interference against microRNA4215p. The expression of 45 miRNAs was significantly different. In total, 13 miRNAs were upregulated, of which 5 miRNA sequences were known and 8 were predicted. Furthermore, 32 miRNAs were downregulated, of which 11 miRNA sequences were known and 21 were predicted. The results of the luciferase reporter assay confirmed the targeting association between miR4215p and MAPK7. The expression levels of MAPK and genes in its downstream signaling pathways, including cFos, CREB and cMyc, were downregulated when miR4215p was overexpressed and upregulated when miR4215p was silenced. The differential expression of miRNAs may serve an important role in the development of the ovary in a light pollution environment. miR4215p may regulate ovarian growth and development by targeting the MAPK signaling pathway in light polluted rat ovaries. |
| Address |
Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China |
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English |
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1107-3756 |
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| Notes |
PMID:30221682 |
Approved |
no |
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GFZ @ kyba @ |
Serial |
2005 |
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Zhao, Z., Zhou, Y., Tan, G., & Li, J. |
| Title |
Research progress about the effect and prevention of blue light on eyes |
Type |
Journal Article |
| Year |
2018 |
Publication |
International Journal of Ophthalmology |
Abbreviated Journal |
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| Volume |
11 |
Issue |
12 |
Pages |
1999-2003 |
| Keywords |
Vision; Human Health; Review |
| Abstract |
In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light's effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment. |
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IDA @ intern @ |
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2313 |
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| Author |
Ahmed, AK; Sadik, MA |
| Title |
Study of sky brightness profiles of Baghdad and Karbala cities in Iraq |
Type |
Journal Article |
| Year |
2018 |
Publication |
International Journal of Science and Nature |
Abbreviated Journal |
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| Volume |
9 |
Issue |
1 |
Pages |
18-24 |
| Keywords |
Skyglow |
| Abstract |
This study was used two detectors only i.e., the human eye and photometer of Sky Quality Meter (SQM-LU) during the time of sunrise and sunset. The human eye used to determine the moon's phase. The measurements of sky brightness, by using SQM-LU, performed via two locations that covered Baghdad and Karbala in Iraq from December 2016 through March 2017 intermittently. The research focused only on light perceived by detectors and not how it happens. The aim of research is to find a mathematical formula (i.e . brightness contrast) between the sky brightness against the solar altitude by taking moon illumination as the standard reference. Analytical software based on the Python's PyEphem astrometry library was developed to calculate the solar altitude at the two locations. Finally, the formula of sky brightness obtained from this work is an important key that contributed to finding the simulated sky brightness, when the sun's altitude is known. |
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no |
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GFZ @ kyba @ |
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1851 |
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Kyba, C.C.M.; Mohar, A.; Pintar, G; Stare, J |
| Title |
Reducing the environmental footprint of church lighting: matching façade shape and lowering luminance with the EcoSky LED |
Type |
Journal Article |
| Year |
2018 |
Publication |
International Journal of Sustainable Lighting |
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20 |
Issue |
1 |
Pages |
1-10 |
| Keywords |
Energy; Lighting; Remote Sensing |
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The lighting of the Church of the Three Kings in Logatec, Slovenia was replaced in 2014. The power of the installation was reduced 96% from 1.6 kW to 58 W, and spill light from the site was effectively eliminated. As a result, the church is no longer visible in nighttime satellite images of the area, indicating a reduction of waste light from the site of at least a factor of 30. This article discusses the concept of sustainability with regards to cultural heritage lighting, within the context of this example. |
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no |
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GFZ @ kyba @ |
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1831 |
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| Author |
Meier; J.M. |
| Title |
Temporal Profiles of Urban Lighting: Proposal for a research design and first results from three sites in Berlin |
Type |
Journal Article |
| Year |
2018 |
Publication |
International Journal of Sustainable Lighting |
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20 |
Issue |
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Pages |
11-28 |
| Keywords |
Instrumentation; Lighting; Society |
| Abstract |
This paper presents and experimentally applies a research design for studying the temporal dimension of outdoor artificial illumination in complex lightscapes such as those of urban centres. It contributes to filling the gap between analyses of high-resolution aerial imagery, which provide detailed but static information on the spatial composition of lightscapes, and existing methods for studying their dynamics, which measure changes at high levels of aggregation. The research design adopts a small-scale, detailed approach by using close-range time-lapse videos to document the on/off patterns of individual light sources as the night progresses. It provides a framework and vocabulary for discrete and comparative analyses of the identified temporal profiles of lighting. This allows for pinpointing similarities and differences among the dynamics of different places, nights or categories of lighting. Its application to three case studies in Berlin indicate that switch-on and switch-off times are clustered, resulting in static and dynamic phases of the night. Midnight is a temporal fault-line, after which full illumination ends as portions of the illumination are extinguished. Switch-off times and -rates differ among the three lightscapes and, especially, among four functional types of lighting that were differentiated: infrastructural and commercial units largely remain on all night, while substantial portions of architectural and indoor lighting are switched off, though at fairly different times. Such findings are valuable for studies based on data collected at specific points in time (aerial imagery, measurements), for informing and monitoring temporally oriented lighting policies, and for understanding urban dynamics at large. |
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no |
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GFZ @ kyba @ |
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1901 |
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