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Author Borck, P.C.; Batista, T.M.; Vettorazzi, J.F.; Soares, G.M.; Lubaczeuski, C.; Guan, D.; Boschero, A.C.; Vieira, E.; Lazar, M.A.; Carneiro, E.M.
Title Nighttime light exposure enhances Rev-erbalpha-targeting microRNAs and contributes to hepatic steatosis Type Journal Article
Year 2018 Publication (up) Metabolism: Clinical and Experimental Abbreviated Journal Metabolism
Volume 85 Issue Pages 250-258
Keywords Animals
Abstract OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbalpha and up-regulation of its lipogenic targets ACL and FAS in liver. Furthermore, the expression of Rev-erbalpha-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group. Consistently, overexpression of these miRNAs in primary hepatocytes reduced Rev-erbalpha expression at the mRNA and protein levels. Importantly, overexpression of Rev-erbalpha-targeting miRNAs increased mRNA levels of Acly and Fasn. CONCLUSION: Thus, altered miRNA profile is an important mechanism underlying the disruption of the peripheral clock caused by exposure to ALAN, which could lead to hepatic steatosis.
Address Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil
Corporate Author Thesis
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0026-0495 ISBN Medium
Area Expedition Conference
Notes PMID:29751019 Approved no
Call Number GFZ @ kyba @ Serial 1891
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Author Wu, B.; Wang, Y.; Wu, X.; Liu, D.; Xu, D.; Wang, F.
Title On-orbit sleep problems of astronauts and countermeasures Type Journal Article
Year 2018 Publication (up) Military Medical Research Abbreviated Journal Mil Med Res
Volume 5 Issue 1 Pages 17
Keywords Human Health
Abstract Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very common among astronauts and has potential detrimental influences on the health of crewmembers and the safety of flight missions. Sleep in space is becoming a new medical research frontier. In this review we summarized on-orbit sleep problems of astronauts and six kinds of causes, and we presented the effects of lack of sleep on performance as well as mental and physical health, then we proposed seven kinds of countermeasures for sleep disturbance in spaceflight, including pharmacologic interventions, light treatment, crew selection and training, Traditional Chinese Medicine and so on. Furthermore, we discussed and oriented the prospect of researches on sleep in space.
Address State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26 Beiqing Road, Haidian District, Beijing, 100094, People's Republic of China
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2054-9369 ISBN Medium
Area Expedition Conference
Notes PMID:29843821; PMCID:PMC5975626 Approved no
Call Number GFZ @ kyba @ Serial 1930
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Author Aubé, M.; Simoneau, A.; Wainscoat, R.; Nelson, L.
Title Modeling the effects of phosphor converted LED lighting to the night sky of the Haleakala Observatory, Hawaii Type Journal Article
Year 2018 Publication (up) Monthly Notices of the Royal Astronomical Society Abbreviated Journal
Volume 478 Issue 2 Pages 1776-1783
Keywords Skyglow
Abstract The goal of this study is to evaluate the current level of light pollution in the night sky at the Haleakala Observatory on the island of Maui in Hawaii. This is accomplished with a numerical model that was tested in the first International Dark Sky Reserve located in Mont-Mégantic National Park in Canada. The model uses ground data on the artificial light sources present in the region of study, geographical data, and remotely sensed data for: 1) the nightly upward radiance; 2) the terrain elevation; and, 3) the ground spectral reflectance of the region. The results of the model give a measure of the current state of the sky spectral radiance at the Haleakala Observatory. Then, using the current state as a reference point, multiple light conversion plans are elaborated and evaluated using the model. We can thus estimate the expected impact of each conversion plan on the night sky radiance spectrum. A complete conversion to white (LEDs) with (CCT) of 4000K and 3000K are contrasted with a conversion using (PC) amber (LEDs). We include recommendations concerning the street lamps to be used in sensitive areas like the cities of Kahului and Kihei and suggest best lighting practices related to the color of lamps used at night.
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Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0035-8711 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 1907
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Author Wang, J., Zhang, J., Gong, L., Li, Q., Zhou, D.
Title Seismic Indirect Economic Loss Assessment and Recovery Evaluation Using Night-time Light Images – Application for Wenchuan Earthquake Type Journal Article
Year 2018 Publication (up) Natural Hazards and Earth System Sciences Abbreviated Journal
Volume In press Issue Pages
Keywords Remote Sensing; Economics
Abstract Seismic indirect economic loss not only has a major impact on regional economic recovery policies, but also related to the economic assistance at the national level. Due to the Cross-regional economic activities and the difficulty of obtaining data, it's difficult that the indirect economic loss survey covers all economic activities. However, night-time light in an area can reflect the economic activity of the region. This paper focuses on the indirect economic losses caused by the Wenchuan earthquake in 2008 and evaluated the progress of restoration and reconstruction based on night-time light Images. First, the functional relationship between GDP and night-time light parameters was established based on the pre-earthquake data. Next, the indirect loss of the earthquake was evaluated by the night-time light attenuation in the disaster area after the earthquake. Then, the capacity recovery, which is characterized by the brightness recovery process of the light area, was evaluated. Lastly, the process of light expansion in the disaster area was analyzed to evaluate the economic expansion speed and efficiency.
Address
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Notes Approved no
Call Number NC @ ehyde3 @ Serial 2064
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Author Pattison, P.M.; Tsao, J.Y.; Brainard, G.C.; Bugbee, B.
Title LEDs for photons, physiology and food Type Journal Article
Year 2018 Publication (up) Nature Abbreviated Journal Nature
Volume 563 Issue 7732 Pages 493-500
Keywords Lighting; Human Health; Plants; Review
Abstract Lighting based on light-emitting diodes (LEDs) not only is more energy efficient than traditional lighting, but also enables improved performance and control. The colour, intensity and distribution of light can now be controlled with unprecedented precision, enabling light to be used both as a signal for specific physiological responses in humans and plants, and as an efficient fuel for fresh food production. Here we show how a broad and improved understanding of the physiological responses to light will facilitate greater energy savings and provide health and productivity benefits that have not previously been associated with lighting.
Address Utah State University, Logan, UT, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0028-0836 ISBN Medium
Area Expedition Conference
Notes PMID:30464269 Approved no
Call Number GFZ @ kyba @ Serial 2110
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