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Author Flores, D.E.F.L.; Oda, G.A.
Title Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator Type Journal Article
Year 2018 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume in press Issue Pages
Keywords Animals
Abstract Artificial lab manipulation of LD cycles has enabled simulations of the disruptive conditions found in modern human societies, such as jet-lag, night-work and light at night. New techniques using animal models have been developed, and these can greatly improve our understanding of circadian disruption. Some of these techniques, such as in vivo bioluminescence assays, require minimum external light. This requirement is challenging because the usual lighting protocols applied in circadian desynchronization experiments rely on considerable light input. Here, we present a novel LD regimen that can disrupt circadian rhythms with little light per day, based on computer simulations of a model limit-cycle oscillator. The model predicts that a single light pulse per day has the potential to disturb rhythmicity when pulse times are randomly distributed within an interval. Counterintuitively, the rhythm still preserves an underlying 24-h periodicity when this interval is as large as 14 h, indicating that day/night cues are still detectable. Only when pulses are spread throughout the whole 24-h day does the rhythm lose any day-to-day period correlation. In addition, the model also reveals that stronger pulses of brighter light should exacerbate the disrupting effects. We propose the use of this LD schedule-which would be compatible with the requirements of in vivo bioluminescence assays-to help understand circadian disruption and associated illnesses.
Address Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes PMID:30595077 Approved no
Call Number GFZ @ kyba @ Serial (down) 2146
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Author Kyba, C.C.M.; Spitschan, M.
Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study' Type Journal Article
Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume in press Issue Pages
Keywords Human Health; Commentary
Abstract
Address Department of Experimental Psychology, University of Oxford, Oxford, UK
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-0920 ISBN Medium
Area Expedition Conference
Notes PMID:30584260 Approved no
Call Number GFZ @ kyba @ Serial (down) 2145
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Author Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A.
Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control
Volume 25 Issue 1 Pages 1073274818812908
Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED
Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.
Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1073-2748 ISBN Medium
Area Expedition Conference
Notes PMID:30477310; PMCID:PMC6259078 Approved no
Call Number IDA @ john @ Serial (down) 2143
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Author Studer, P.; Brucker, J.M.; Haag, C.; Van Doren, J.; Moll, G.H.; Heinrich, H.; Kratz, O.
Title Effects of blue- and red-enriched light on attention and sleep in typically developing adolescents Type Journal Article
Year 2018 Publication Physiology & Behavior Abbreviated Journal Physiol Behav
Volume 199 Issue Pages 11-19
Keywords Human Health
Abstract Differential effects of blue- and red-enriched light on attention and sleep have been primarily described in adults. In our cross-over study in typically developing adolescents (11-17years old), we found attention enhancing effects of blue- compared to red-enriched light in the morning (high intensity of ca. 1000lx, short duration: <1h) in two of three attention tasks: e.g. better performance in math tests and reduced reaction time variability in a computerized attention test. In our pilot study, actigraphy measures of sleep indicated slight benefits for red- compared to blue-enriched light in the evening: tendencies toward a lower number of phases with movement activity after sleep onset in the complete sample and shorter sleep onset latency in a subgroup with later evening exposure times. These findings point to the relevance of light concepts regarding attention and sleep in typically developing adolescents. Such concepts should be developed and tested further in attention demanding contexts (at school) and for therapeutic purposes in adolescents with impaired attention or impaired circadian rhythms.
Address Department of Child and Adolescent Mental Health, University Hospital Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. Electronic address: oliver.kratz@uk-erlangen.de
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9384 ISBN Medium
Area Expedition Conference
Notes PMID:30381244 Approved no
Call Number GFZ @ kyba @ Serial (down) 2142
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Author Morelli, F.; Mikula, P.; Benedetti, Y.; Bussière, R.; Tryjanowski, P.
Title Cemeteries support avian diversity likewise urban parks in European cities: Assessing taxonomic, evolutionary and functional diversity Type Journal Article
Year 2018 Publication Urban Forestry & Urban Greening Abbreviated Journal Urban Forestry & Urban Greening
Volume 36 Issue Pages 90-99
Keywords Animals; Ecology
Abstract The aim of this study was to explore different components of avian diversity in two types of urban green areas, parks and cemeteries, in four European countries in relation to environmental characteristics. We studied bird species richness, functional diversity and evolutionary distinctiveness in 79 parks and 90 cemeteries located in four European countries: the Czech Republic, France, Italy and Poland.

First, we found no significant differences between cemeteries and parks in bird diversity. However, in both parks and cemeteries, only: two community metrics were affected by different environmental characteristics, including local vegetation structure and presence of human-related structures. Species richness was positively correlated with tree coverage and site size, functional diversity was unrelated to any of the measured variables, while the mean evolutionary distinctiveness score was positively correlated with tree coverage and negatively associated with the coverage of flowerbeds and number of street lamps.

Our findings can be useful for urban planning: by increasing tree coverage and site size it is possible to increase both taxonomic richness and evolutionary uniqueness of bird communities. In both parks and cemeteries, the potential association between light pollution and bird species richness was negligible. We also identified some thresholds where bird diversity was higher. Bird species richness was maximized in parks/cemeteries larger than 1.4 ha, with grass coverage lower than 65%. The evolutionary uniqueness of bird communities was higher in areas with tree coverage higher than 45%. In conclusion, the findings of this study provide evidence that cemeteries work similarly than urban parks supporting avian diversity.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1618-8667 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial (down) 2141
Permanent link to this record