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Author Nelson, R.J.; Chbeir, S. url  doi
openurl 
  Title Dark matters: effects of light at night on metabolism Type Journal Article
  Year 2018 Publication The Proceedings of the Nutrition Society Abbreviated Journal Proc Nutr Soc  
  Volume 77 Issue 3 Pages 223-229  
  Keywords Human Health  
  Abstract Life on earth has evolved during the past several billion years under relatively bright days and dark night conditions. The wide-spread adoption of electric lights during the past century exposed animals, both human and non-human, to significant light at night for the first time in their evolutionary history. Endogenous circadian clocks depend on light to entrain to the external daily environment and seasonal rhythms depend on clear nightly melatonin signals to assess time of year. Thus, light at night can derange temporal adaptations. Indeed, disruption of naturally evolved light-dark cycles results in several physiological and behavioural changes with potentially serious implications for physiology, behaviour and mood. In this review, data from night-shift workers on their elevated risk for metabolic disorders, as well as data from animal studies will be discussed. Night-shift workers are predisposed to obesity and dysregulated metabolism that may result from disrupted circadian rhythms. Although studies in human subjects are correlative, animal studies have revealed several mechanisms through which light at night may exert its effects on metabolism by disrupting circadian rhythms that are associated with inflammation, both in the brain and in the periphery. Disruption of the typical timing of food intake is a key effect of light at night and subsequent metabolic dysregulation. Strategies to avoid the effects of light at night on body mass dysregulation should be pursued.  
  Address Department of Neuroscience,The Ohio State University,Columbus, OH 43210,USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0029-6651 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29747703 Approved no  
  Call Number GFZ @ kyba @ Serial (up) 1896  
Permanent link to this record
 

 
Author McKenna, H.; van der Horst, G.T.J.; Reiss, I.; Martin, D. url  doi
openurl 
  Title Clinical chronobiology: a timely consideration in critical care medicine Type Journal Article
  Year 2018 Publication Critical Care (London, England) Abbreviated Journal Crit Care  
  Volume 22 Issue 1 Pages 124  
  Keywords Human Health; Review  
  Abstract A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature conserved across most life on Earth. Organisms compartmentalise processes with respect to time in order to promote survival, in a manner that mirrors the rotation of the planet and accompanying diurnal cycles of light and darkness. The influence of circadian rhythms can no longer be overlooked in clinical settings; this review provides intensivists with an up-to-date understanding of the burgeoning field of chronobiology, and suggests ways to incorporate these concepts into daily practice to improve patient outcomes. We outline the function of molecular clocks in remote tissues, which adjust cellular and global physiological function according to the time of day, and the potential clinical advantages to keeping in time with them. We highlight the consequences of “chronopathology”, when this harmony is lost, and the risk factors for this condition in critically ill patients. We introduce the concept of “chronofitness” as a new target in the treatment of critical illness: preserving the internal synchronisation of clocks in different tissues, as well as external synchronisation with the environment. We describe methods for monitoring circadian rhythms in a clinical setting, and how this technology may be used for identifying optimal time windows for interventions, or to alert the physician to a critical deterioration of circadian rhythmicity. We suggest a chronobiological approach to critical illness, involving multicomponent strategies to promote chronofitness (chronobundles), and further investment in the development of personalised, time-based treatment for critically ill patients.  
  Address Critical Care Unit, Royal Free Hospital, Pond Street, London, NW3 2QG, UK. daniel.martin@ucl.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1364-8535 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29747699 Approved no  
  Call Number GFZ @ kyba @ Serial (up) 1897  
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Author Scheuermaier, K.; Munch, M.; Ronda, J.M.; Duffy, J.F. url  doi
openurl 
  Title Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening Type Journal Article
  Year 2018 Publication Behavioural Brain Research Abbreviated Journal Behav Brain Res  
  Volume 348 Issue Pages 267-275  
  Keywords Human Health  
  Abstract OBJECTIVES: Exposure to light can have acute alerting and circadian phase-shifting effects. This study investigated the effects of evening exposure to blue-enriched polychromatic white (BEL) vs. polychromatic white light (WL) on sleep inertia dissipation the following morning in older adults. METHODS: Ten healthy older adults (average age=63.3 yrs; 6F) participated in a 13-day study comprising three baseline days, an initial circadian phase assessment, four days with 2-h evening light exposures, a post light exposure circadian phase assessment and three recovery days. Participants were randomized to either BEL or WL of the same irradiance for the four evening light exposures. On the next mornings at 2, 12, 22 and 32min after each wake time, the participants completed a 90-s digit-symbol substitution test (DSST) to assess working memory, and objective alertness was assessed using a wake EEG recording. DSST and power density from the wake EEG recordings were compared between the two groups. RESULTS: DSST performance improved with time awake (p<0.0001) and across study days in both light exposure groups (p<0.0001). There was no main effect of group, although we observed a significant day x group interaction (p=0.0004), whereby participants exposed to BEL performed significantly better on the first two mornings after light exposures than participants in WL (post-hoc, p<0.05). On those days, the BEL group showed higher EEG activity in some of the frequency bins in the sigma and beta range (p<0.05) on the wake EEG. CONCLUSION: Exposure to blue-enriched white light in the evening significantly improved DSST performance the following morning when compared to polychromatic white light. This was associated with a higher level of objective alertness on the wake EEG, but not with changes in sleep or circadian timing.  
  Address Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0166-4328 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29684473 Approved no  
  Call Number GFZ @ kyba @ Serial (up) 1899  
Permanent link to this record
 

 
Author Grubisic, M.; van Grunsven, R.H.A.; Manfrin, A.; Monaghan, M.T.; Hölker, F. url  doi
openurl 
  Title A transition to white LED increases ecological impacts of nocturnal illumination on aquatic primary producers in a lowland agricultural drainage ditch Type Journal Article
  Year 2018 Publication Environmental Pollution Abbreviated Journal Environmental Pollution  
  Volume 240 Issue Pages 630-638  
  Keywords Plants; Ecology  
  Abstract The increasing use of artificial light at night (ALAN) has led to exposure of freshwater ecosystems to light pollution worldwide. Simultaneously, the spectral composition of nocturnal illumination is changing, following the current shift in outdoor lighting technologies from traditional light sources to light emitting diodes (LED). LEDs emit broad-spectrum white light, with a significant amount of photosynthetically active radiation, and typically a high content of blue light that regulates circadian rhythms in many organisms. While effects of the shift to LED have been investigated in nocturnal animals, its impact on primary producers is unknown. We performed three field experiments in a lowland agricultural drainage ditch to assess the impacts of a transition from high-pressure sodium (HPS) to white LED illumination (color temperature 4000 K) on primary producers in periphyton. In all experiments, we compared biomass and pigment composition of periphyton grown under a natural light regime to that of periphyton exposed to nocturnal HPS or, consecutively, LED light of intensities commonly found in urban waters (approximately 20 lux). Periphyton was collected in time series (1–13 weeks). We found no effect of HPS light on periphyton biomass; however, following a shift to LED the biomass decreased up to 62%. Neither light source had a substantial effect on pigment composition. The contrasting effects of the two light sources on biomass may be explained by differences in their spectral composition, and in particular the blue content. Our results suggest that spectral composition of the light source plays a role in determining the impacts of ALAN on periphyton and that the ongoing transition to LED may increase the ecological impacts of artificial lighting on aquatic primary producers. Reduced biomass in the base of the food web can impact ecosystem functions such as productivity and food supply for higher trophic levels in nocturnally-lit ecosystems.  
  Address  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0269-7491 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (up) 1900  
Permanent link to this record
 

 
Author Meier; J.M. openurl 
  Title Temporal Profiles of Urban Lighting: Proposal for a research design and first results from three sites in Berlin Type Journal Article
  Year 2018 Publication International Journal of Sustainable Lighting Abbreviated Journal  
  Volume 20 Issue Pages 11-28  
  Keywords Instrumentation; Lighting; Society  
  Abstract This paper presents and experimentally applies a research design for studying the temporal dimension of outdoor artificial illumination in complex lightscapes such as those of urban centres. It contributes to filling the gap between analyses of high-resolution aerial imagery, which provide detailed but static information on the spatial composition of lightscapes, and existing methods for studying their dynamics, which measure changes at high levels of aggregation. The research design adopts a small-scale, detailed approach by using close-range time-lapse videos to document the on/off patterns of individual light sources as the night progresses. It provides a framework and vocabulary for discrete and comparative analyses of the identified temporal profiles of lighting. This allows for pinpointing similarities and differences among the dynamics of different places, nights or categories of lighting. Its application to three case studies in Berlin indicate that switch-on and switch-off times are clustered, resulting in static and dynamic phases of the night. Midnight is a temporal fault-line, after which full illumination ends as portions of the illumination are extinguished. Switch-off times and -rates differ among the three lightscapes and, especially, among four functional types of lighting that were differentiated: infrastructural and commercial units largely remain on all night, while substantial portions of architectural and indoor lighting are switched off, though at fairly different times. Such findings are valuable for studies based on data collected at specific points in time (aerial imagery, measurements), for informing and monitoring temporally oriented lighting policies, and for understanding urban dynamics at large.  
  Address  
  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (up) 1901  
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