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Author Matveyenko, A.V.
Title (up) Consideration for Circadian Physiology in Rodent Research Type Journal Article
Year 2018 Publication Physiology (Bethesda, Md.) Abbreviated Journal Physiology (Bethesda)
Volume 33 Issue 4 Pages 250-251
Keywords Animals; Commentary
Abstract
Address Mayo Clinic , Rochester, Minnesota
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1548-9221 ISBN Medium
Area Expedition Conference
Notes PMID:29873599 Approved no
Call Number GFZ @ kyba @ Serial 1935
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Author Maroni, M.J.; Capri, K.M.; Cushman, A.V.; Monteiro De Pina, I.K.; Chasse, M.H.; Seggio, J.A.
Title (up) Constant light alters serum hormone levels related to thyroid function in male CD-1 mice Type Journal Article
Year 2018 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume 35 Issue 10 Pages 1456-1463
Keywords Animals
Abstract Disruptions to the circadian rhythm can lead to altered metabolism. Modification of thyroid function may be a reason why circadian misalignment may contribute to future metabolic disorders. We investigated whether circadian disruption through constant light (LL) can lead to variations in hormone levels associated with thyroid function. Mice were exposed to LL or a 12:12 Light:Dark (LD) cycle for 6 weeks; then glucose tolerance and thyroid hormone levels were measured at ZT 6 and ZT 18. There was day/night variation in glucose tolerance, but LL had no effect. LL reduced TSH, increased fT4, and abolished day/night variation in fT3 and leptin. These findings illustrate that LL alters thyroid-related hormones, providing evidence of a link between circadian disruption and thyroid function.
Address a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:29953263 Approved no
Call Number GFZ @ kyba @ Serial 1958
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Author Madahi, P.-G.; Ivan, O.; Adriana, B.; Diana, O.; Carolina, E.
Title (up) Constant light during lactation programs circadian and metabolic systems Type Journal Article
Year 2018 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume 35 Issue 8 Pages 1153-1167
Keywords Animals
Abstract Exposure to light at night is a disruptive condition for the adult circadian system, leading to arrhythmicity in nocturnal rodents. Circadian disruption is a risk factor for developing physiological and behavioral alterations, including weight gain and metabolic disease. During early stages of development, the circadian system undergoes a critical period of adjustment, and it is especially vulnerable to altered lighting conditions that may program its function, leading to long-term effects. We hypothesized that during lactation a disrupted light-dark cycle due to light at night may disrupt the circadian system and in the long term induce metabolic disorders. Here we explored in pups, short- and long-term effects of constant light (LL) during lactation. In the short term, LL caused a loss of rhythmicity and a reduction in the immunopositive cells of VIP, AVP, and PER1 in the suprachiasmatic nucleus (SCN). In the short term, the affection on the circadian clock in the pups resulted in body weight gain, loss of daily rhythms in general activity, plasma glucose and triglycerides (TG). Importantly, the DD conditions during development also induced altered daily rhythms in general activity and in the SCN. Exposure to LD conditions after lactation did not restore rhythmicity in the SCN, and the number of immunopositve cells to VIP, AVP, and PER1 remained reduced. In the long term, daily rhythmicity in general activity was restored; however, daily rhythms in glucose and TG remained disrupted, and daily mean levels of TG were significantly increased. Present results point out the programming role played by the LD cycle during early development in the function of the circadian system and on metabolism. This study points out the risk represented by exposure to an altered light-dark cycle during early stages of development. ABBREVIATIONS: AVP: arginine vasopressin peptide; CRY: cryptochrome; DD: constant darkness; DM: dorsomedial; LD: light-dark cycle; LL: constant light; NICUs: neonatal intensive care units; P: postnatal days; PER: period; S.E.M.: standard error of the mean; SCN: suprachiasmatic nucleus; TG: triglycerides; VIP: vasointestinal peptide; VL: ventrolateral; ZT: zeitgeber time.
Address a Facultad de Medicina , Universidad Nacional Autonoma de Mexico, UNAM , Mexico City , Mexico
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:29688088 Approved no
Call Number GFZ @ kyba @ Serial 1884
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Author Chen, Y.; Cheng, M.; Su, T.; Gao, T.; Yu, W.
Title (up) Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats Type Journal Article
Year 2018 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun
Volume in press Issue Pages
Keywords Animals
Abstract Constant light exposure is widespread in the intensive care unit (ICU) and could increase the rate of brain dysfunction as delirium and sleep disorders in critical patients. And the activation of hypothalamic neuropeptides is proved to play a crucial role in regulating hypercatabolism, especially skeletal muscle wasting in critical patients, which could lead to serious complications and poor prognosis. Here we investigated the hypothesis that constant light exposure could aggravate skeletal muscle wasting in endotoxemia rats and whether it was associated with alterations of circadian clock and hypothalamic proopiomelanocortin(POMC) expression. Fifty-four adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide(LPS) or saline, subjected to constant light or a 12:12h light-dark cycle for 7 days. On day 8, rats were sacrificed across six time points in 24h and hypothalamus tissues and skeletal muscle were obtained. Rates of muscle wasting were measured by 3-methylhistidine(3-MH) and tyrosine release as well as expression of two muscle atrophic genes, muscle ring finger 1(MuRF-1) and muscle atrophy F-box(MAFbx). The expression of circadian clock genes, silent information regulator 1(SIRT1), POMC and hypothalamic inflammatory cytokines were also detected. Results showed that LPS administration significantly increased hypothalamic POMC expression, inflammatory cytokine levels and muscle wasting rates. Meanwhile constant light exposure disrupted the circadian rhythm, declined the expression of SIRT1 as well as aggravated hypothalamic POMC overexpression and skeletal muscle wasting in rats with endotoxemia. Taken together, the results demonstrated that constant light exposure could aggravate POMC-mediated skeletal muscle wasting in endotoxemia rats, which is associated with alteration of circadian clocks and SIRT1 in the hypothalamus.
Address Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: yudrnj2@163.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0006-291X ISBN Medium
Area Expedition Conference
Notes PMID:30528733 Approved no
Call Number GFZ @ kyba @ Serial 2134
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Author Meier, J.
Title (up) Contentious Light: An Analytical Framework for Lighting Conflicts Type Journal Article
Year 2018 Publication International Journal of Sustainable Lighting Abbreviated Journal
Volume 20 Issue 1 Pages 62-77
Keywords Society; Lighting; Planning
Abstract This paper takes into view the broad range of contemporary conflicts regarding outdoor lighting. It proposes a working-definition that allows for differentiating lighting conflicts from other forms of lighting-related contention, as well as an analytical framework that allows for the structured description of individual lighting conflicts, and the comparative analysis of multiple cases. The analytical framework was developed based on the social-scientific analysis of media reports of existing conflict cases in Europe and North America, and informed by existing knowledge from the fields of lighting and conflict studies. A central challenge for developing such a framework is dealing with the high level of contingency and complexity of lighting conflicts. The framework reduces this complexity by focusing its field of vision to those aspects that are directly related to the lighting and its contestation. For each of these aspects, it provides sets of descriptive variables that allow for describing the conflicts’ individuality in a standardized – and thus comparable – way. The framework strictly separates the regarded aspects from their judgment by the conflict parties, making it possible to contrast their views on one and the same lighting situation. A visual template supports the process of analysis. It allows for depicting individual cases in short, and for clearly identifying where perspectives differ. At the multiple-case level, the framework not only opens up possibilities for spatial and temporal comparisons of lighting conflicts and the subsequent development of typologies, but also for harnessing their potential for informing the development of more sustainable planning and policy approaches for artificial lighting.
Address Department of Urban and Regional Planning, Technische Universität Berlin, Germany; josiane.meier(at)tu-berlin.de
Corporate Author Thesis
Publisher IJSL Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2190
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