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Author McGlashan, E.M.; Nandam, L.S.; Vidafar, P.; Mansfield, D.R.; Rajaratnam, S.M.W.; Cain, S.W. url  doi
openurl 
  Title The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose Type Journal Article
  Year 2018 Publication Psychopharmacology Abbreviated Journal Psychopharmacology (Berl)  
  Volume in press Issue Pages in press  
  Keywords Human Health  
  Abstract RATIONALE: Disturbances of the circadian system are common in depression. Though they typically subside when depression is treated with antidepressants, the mechanism by which this occurs is unknown. Despite being the most commonly prescribed class of antidepressants, the effect of selective serotonin reuptake inhibitors (SSRIs) on the human circadian clock is not well understood. OBJECTIVE: To examine the effect of the SSRI citalopram (30 mg) on the sensitivity of the human circadian system to light. METHODS: This study used a double-blind, placebo-controlled, within-subjects, crossover design. Participants completed two melatonin suppression assessments in room level light (~ 100 lx), taking either a single dose of citalopram 30 mg or a placebo at the beginning of each light exposure. Melatonin suppression was calculated by comparing placebo and citalopram light exposure conditions to a dim light baseline. RESULTS: A 47% increase in melatonin suppression was observed after administration of an acute dose of citalopram, with all participants showing more suppression after citalopram administration (large effect, d = 1.54). Further, melatonin onset occurred later under normal room light with citalopram compared to placebo. CONCLUSIONS: Increased sensitivity of the circadian system to light could assist in explaining some of the inter-individual variability in antidepressant treatment responses, as it is likely to assist in recovery in some patients, while causing further disruption for others.  
  Address Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. sean.cain@monash.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0033-3158 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30219986 Approved no  
  Call Number GFZ @ kyba @ Serial 2012  
Permanent link to this record
 

 
Author Taufique, S.K.T.; Prabhat, A.; Kumar, V. url  doi
openurl 
  Title Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids Type Journal Article
  Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume in press Issue Pages in press  
  Keywords Animals  
  Abstract Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 h light (150 lux): 12 h darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals. Dim light (6 lux) at night (dLAN) altered daily activity:rest pattern, reduced sleep and induced depressive-like responses (decreased eating and self-grooming, self-mutilation and reduced novel object exploration); return to an absolute dark night reversed these negative effects. dLAN suppressed nocturnal melatonin levels, however, diurnal corticosterone levels were unaffected. Concomitant reduction of immunoreactivity for DCX and BDNF suggested dLAN-induced suppression of hippocampal neurogenesis and compromised neuronal health. dLAN also negatively influenced hippocampal expression of genes associated with depressive-like responses (bdnf, il-1beta, tnfr1, nr4a2), but not of those associated with neuronal plasticity (egr1, creb, syngap, syn2, grin2a, grin2b), cellular oxidative stress (gst, sod3, cat1) and neuronal death (caspase2, caspase3, foxo3). Furthermore, we envisaged the role of BDNF and showed epigenetic modification of bdnf gene by decreased histone H3 acetylation and increased hdac4 expression under dLAN. These results demonstrate transcriptional and epigenetic bases of dLAN-induced negative effects in diurnal crows, and provide insights into the risks of exposure to illuminated nights to animals including humans in an urban setting. This article is protected by copyright. All rights reserved.  
  Address IndoUS Center for Biological Timing Department of Zoology, University of Delhi, Delhi, 110 007, India  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30218624 Approved no  
  Call Number GFZ @ kyba @ Serial 2010  
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Author Stern, M.; Broja, M.; Sansone, R.; Grone, M.; Skene, S.S.; Liebmann, J.; Suschek, C.V.; Born, M.; Kelm, M.; Heiss, C. url  doi
openurl 
  Title Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans Type Journal Article
  Year 2018 Publication European Journal of Preventive Cardiology Abbreviated Journal Eur J Prev Cardiol  
  Volume 25 Issue 17 Pages 1875-1883  
  Keywords Human Health; Blue light; blood pressure; endothelial function; forearm blood flow; pulse wave velocity  
  Abstract AIMS: Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also decrease blood pressure and increase endothelial function in healthy subjects. METHODS: In a randomised crossover study, 14 healthy male subjects were exposed on 2 days to monochromatic blue light or blue light with a filter foil (control light) over 30 minutes. We measured blood pressure (primary endpoint), heart rate, forearm vascular resistance, forearm blood flow, endothelial function (flow-mediated dilation), pulse wave velocity and plasma nitric oxide species, nitrite and nitroso compounds (secondary endpoints) during and up to 2 hours after exposure. RESULTS: Blue light exposure significantly decreased systolic blood pressure and increased heart rate as compared to control. In parallel, blue light significantly increased forearm blood flow, flow-mediated dilation, circulating nitric oxide species and nitroso compounds while it decreased forearm vascular resistance and pulse wave velocity. CONCLUSION: Whole body irradiation with visible blue light at real world doses improves blood pressure, endothelial function and arterial stiffness by nitric oxide released from photolabile intracutanous nitric oxide metabolites into circulating blood.  
  Address Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford GU2 7XH, UK. Email: c.heiss(at)  
  Corporate Author Thesis  
  Publisher SAGE Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2047-4873 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30196723 Approved no  
  Call Number IDA @ john @ Serial 2157  
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Author Kelsey, E.C.; Felis, J.J.; Czapanskiy, M.; Pereksta, D.M.; Adams, J. url  doi
openurl 
  Title Collision and displacement vulnerability to offshore wind energy infrastructure among marine birds of the Pacific Outer Continental Shelf Type Journal Article
  Year 2018 Publication Journal of Environmental Management Abbreviated Journal J Environ Manage  
  Volume 227 Issue Pages 229-247  
  Keywords Animals  
  Abstract Marine birds are vulnerable to collision with and displacement by offshore wind energy infrastructure (OWEI). Here we present the first assessment of marine bird vulnerability to potential OWEI in the California Current System portion of the U.S. Pacific Outer Continental Shelf (POCS). Using population size, demography, life history, flight heights, and avoidance behavior for 62 seabird and 19 marine water bird species that occur in the POCS, we present and apply equations to calculate Population Vulnerability, Collision Vulnerability, and Displacement Vulnerability to OWEI for each species. Species with greatest Population vulnerability included those listed as species of concern (e.g., Least Tern [Sternula antillarum], Marbled Murrelet [Brachyramphus marmoratus], Pink-footed Shearwater [Puffinus creatopus]) and resident year-round species with small population sizes (e.g., Ashy Storm-Petrel [Oceanodroma homochroa], Brandt's Cormorant [Phalacrocorax penicillatus], and Brown Pelican [Pelecanus occidentalis]). Species groups with the greatest Collision Vulnerability included jaegers/skuas, pelicans, terns and gulls that spend significant amounts of time flying at rotor sweep zone height and don't show macro-avoidance behavior (avoidance of entire OWEI area). Species groups with the greatest Displacement Vulnerability show high macro-avoidance behavior and low habitat flexibility and included loons, grebes, sea ducks, and alcids. Using at-sea survey data from the southern POCS, we combined species-specific vulnerabilities described above with at-sea species densities to assess vulnerabilities spatially. Spatial vulnerability densities were greatest in areas with high species densities (e.g., near-shore areas) and locations where species with high vulnerability were found in abundance. Our vulnerability assessment helps understand and minimize potential impacts of OWEI infrastructure on marine birds in the POCS and could inform management decisions.  
  Address U.S. Geological Survey Western Ecological Research Center, Santa Cruz, CA 95062, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0301-4797 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30195148 Approved no  
  Call Number GFZ @ kyba @ Serial 2122  
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Author Christie, S.; Vincent, A.D.; Li, H.; Frisby, C.L.; Kentish, S.J.; O'Rielly, R.; Wittert, G.A.; Page, A.J. url  doi
openurl 
  Title A rotating light cycle promotes weight gain and hepatic lipid storage in mice Type Journal Article
  Year 2018 Publication American Journal of Physiology. Gastrointestinal and Liver Physiology Abbreviated Journal Am J Physiol Gastrointest Liver Physiol  
  Volume in press Issue Pages  
  Keywords Animals  
  Abstract Processes involved in regulation of energy balance and intermediary metabolism are aligned to the light-dark cycle. Shift-work and high fat diet (HFD)-induced obesity disrupt circadian rhythmicity and are associated with increased risk of non-alcoholic fatty liver disease (NAFLD). This study aimed to determine the effect of simulating shift work on hepatic lipid accumulation in lean and HFD-mice. C57BL/6 mice fed a standard laboratory diet (SLD) or HFD for 4wks were further allocated to a normal light (NL)-cycle (lights on:0600-1800hr) or rotating light (RL)-cycle (3-days NL and 4-days reversed (lights on:1800-0600hr) repeated) for 8wks. Tissue was collected every 3hrs beginning at 0600hr. HFD-mice gained more weight than SLD-mice, and RL-mice gained more weight than NL-mice. SLD-NL and HFD-NL mice, but not RL-mice, were more active, had higher respiratory quotients and consumed/expended more energy during the dark phase compared to the light phase. Blood glucose and plasma cholesterol and triglyceride concentrations were elevated in HFD and SLD-RL compared to SLD-NL mice. Hepatic glycogen was elevated in HFD compared to SLD-mice. Hepatic triglycerides were elevated in SLD-RL and HFD-mice compared to SLD-NL. Circadian rhythmicity of hepatic acetyl-CoA carboxylase (ACACA) mRNA was phase shifted in SLD-RL and HFD-NL and lost in HFD-RL mice. Hepatic ACACA protein was reduced in SLD-RL and HFD-mice compared to SLD-NL mice. Hepatic adipose triglyceride lipase was elevated in HFD-NL compared to SLD-NL but lower in RL-mice compared to NL-mice irrespective of diet. -Conclusion: A RL-cycle model of shift-work promotes weight gain and hepatic lipid storage even in lean conditions.  
  Address Adelaide Medical School, University of Adelaide, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0193-1857 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30188750 Approved no  
  Call Number GFZ @ kyba @ Serial 2123  
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