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Author Gonzalez, M.M.C.
Title Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents Type Journal Article
Year 2018 Publication Frontiers in Neurology Abbreviated Journal Front Neurol
Volume (down) 9 Issue Pages 609
Keywords Animals; Review
Abstract The influence of light on mammalian physiology and behavior is due to the entrainment of circadian rhythms complemented with a direct modulation of light that would be unlikely an outcome of circadian system. In mammals, physiological and behavioral circadian rhythms are regulated by the suprachiasmatic nucleus (SCN) of the hypothalamus. This central control allows organisms to predict and anticipate environmental change, as well as to coordinate different rhythmic modalities within an individual. In adult mammals, direct retinal projections to the SCN are responsible for resetting and synchronizing physiological and behavioral rhythms to the light-dark (LD) cycle. Apart from its circadian effects, light also has direct effects on certain biological functions in such a way that the participation of the SCN would not be fundamental for this network. The objective of this review is to increase awareness, within the scientific community and commercial providers, of the fact that laboratory rodents can experience a number of adverse health and welfare outcomes attributed to commonly-used lighting conditions in animal facilities during routine husbandry and scientific procedures, widely considered as “environmentally friendly.” There is increasing evidence that exposure to dim light at night, as well as chronic constant darkness, challenges mammalian physiology and behavior resulting in disrupted circadian rhythms, neural death, a depressive-behavioral phenotype, cognitive impairment, and the deregulation of metabolic, physiological, and synaptic plasticity in both the short and long terms. The normal development and good health of laboratory rodents requires cyclical light entrainment, adapted to the solar cycle of day and night, with null light at night and safe illuminating qualities during the day. We therefore recommend increased awareness of the limited information available with regards to lighting conditions, and therefore that lighting protocols must be taken into consideration when designing experiments and duly highlighted in scientific papers. This practice will help to ensure the welfare of laboratory animals and increase the likelihood of producing reliable and reproducible results.
Address Seccion Cronobiologia y Sueno, Instituto Ferrero de Neurologia y Sueno, Buenos Aires, Argentina
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1664-2295 ISBN Medium
Area Expedition Conference
Notes PMID:30116218; PMCID:PMC6084421 Approved no
Call Number NC @ ehyde3 @ Serial 2084
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Author Buonfiglio, D.; Parthimos, R.; Dantas, R.; Cerqueira Silva, R.; Gomes, G.; Andrade-Silva, J.; Ramos-Lobo, A.; Amaral, F.G.; Matos, R.; Sinesio, J.J.; Motta-Teixeira, L.C.; Donato, J.J.; Reiter, R.J.; Cipolla-Neto, J.
Title Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats Type Journal Article
Year 2018 Publication Frontiers in Endocrinology Abbreviated Journal Front Endocrinol (Lausanne)
Volume (down) 9 Issue Pages 122
Keywords Human health
Abstract Melatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclear; herein we investigated how Mel regulates energy intake and expenditure to promote a proper energy balance. Male Wistar rats were assigned to control, control + Mel, pinealectomized (PINX) and PINX + Mel groups. To restore a 24-h rhythm, Mel (1 mg/kg) was added to the drinking water exclusively during the dark phase for 13 weeks. After this treatment period, rats were subjected to a 24-h fasting test, an acute leptin responsiveness test and cold challenge. Mel treatment reduced food intake, body weight, and adiposity. When challenged to 24-h fasting, Mel-treated rats also showed reduced hyperphagia when the food was replaced. Remarkably, PINX rats exhibited leptin resistance; this was likely related to the capacity of leptin to affect body weight, food intake, and hypothalamic signal-transducer and activator of transcription 3 phosphorylation, all of which were reduced. Mel treatment restored leptin sensitivity in PINX rats. An increased hypothalamic expression of agouti-related peptide (Agrp), neuropeptide Y, and Orexin was observed in the PINX group while Mel treatment reduced the expression of Agrp and Orexin. In addition, PINX rats presented lower UCP1 protein levels in the brown adipose tissue and required higher tail vasoconstriction to get a proper thermogenic response to cold challenge. Our findings reveal a previously unrecognized interaction of Mel and leptin in the hypothalamus to regulate the energy balance. These findings may help to explain the high incidence of metabolic diseases in individuals exposed to light at night.
Address Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of Sao Paulo (USP), Sao Paulo, Brazil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1664-2392 ISBN Medium
Area Expedition Conference
Notes PMID:29636725; PMCID:PMC5881424 Approved no
Call Number NC @ ehyde3 @ Serial 2093
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Author McGlashan, E.M.; Poudel, G.R.; Vidafar, P.; Drummond, S.P.A.; Cain, S.W.
Title Imaging Individual Differences in the Response of the Human Suprachiasmatic Area to Light Type Journal Article
Year 2018 Publication Frontiers in Neurology Abbreviated Journal Front. Neurol.
Volume (down) 9 Issue Pages
Keywords Human Health
Abstract Circadian disruption is associated with poor health outcomes, including sleep and mood disorders. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus acts as the master biological clock in mammals, regulating circadian rhythms throughout the body. The clock is synchronized to the day/night cycle via retinal light exposure. The BOLD-fMRI response of the human suprachiasmatic area to light has been shown to be greater in the night than in the day, consistent with the known sensitivity of the clock to light at night. Whether the BOLD-fMRI response of the human suprachiasmatic area to light is related to a functional outcome has not been demonstrated. In a pilot study (n = 10), we investigated suprachiasmatic area activation in response to light in a 30 s block-paradigm of lights on (100 lux) and lights off (< 1 lux) using the BOLD-fMRI response, compared to each participant's melatonin suppression response to moderate indoor light (100 lux). We found a significant correlation between activation in the suprachiasmatic area in response to light in the scanner and melatonin suppression, with increased melatonin suppression being associated with increased suprachiasmatic area activation in response to the same light level. These preliminary findings are a first step toward using imaging techniques to measure individual differences in circadian light sensitivity, a measure that may have clinical relevance in understanding vulnerability in disorders that are influenced by circadian disruption.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1664-2295 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number NC @ ehyde3 @ Serial 2114
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Author Shor, E.; Potavskaya, R.; Kurtz, A.; Paik, I.; Huq, E.; Green, R.
Title PIF-mediated sucrose regulation of the circadian oscillator is light quality and temperature dependent Type Journal Article
Year 2018 Publication Genes Abbreviated Journal Genes (Basel)
Volume (down) 9 Issue 12 Pages
Keywords Plants
Abstract Studies are increasingly showing that metabolic and circadian (~24 h) pathways are strongly interconnected, with the circadian system regulating the metabolic state of the cell, and metabolic products feeding back to entrain the oscillator. In plants, probably the most significant impact of the circadian system on metabolism is in its reciprocal regulation of photosynthesis; however, the pathways by which this occurs are still poorly understood. We have previously shown that members of the basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME INTERACTING FACTOR (PIF) family are involved in the photosynthate entrainment of the circadian oscillator. In this paper, using Arabidopsis mutants and overexpression lines, we examine how temperature and light quality affect PIF-mediated sucrose signaling to the oscillator and examine the contributions of individual PIF members. Our results also show that the quality of light is important for PIF signaling, with red and blue lights having the opposite effects, and that temperature affects PIF-mediated sucrose signaling. We propose the light sensitivity of PIF-mediated sucrose entrainment of the oscillator may be important in enabling plants to distinguish between sucrose produced de novo from photosynthesis during the day and the sucrose products of starch degradation at the end of the night.
Address Department of Plant and Environmental Sciences, Institute for Life Sciences, Edmond J. Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, Israel. rgreen@mail.huji.ac.il
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2073-4425 ISBN Medium
Area Expedition Conference
Notes PMID:30551669; PMCID:PMC6316277 Approved no
Call Number GFZ @ kyba @ Serial 2155
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Author Malik, N.; Raj, A.; Dhasmana, R.; Bahadur, H.
Title Effect of Late Night Studying and Excessive Use of Video Display Terminals on the Ocular Health of Medical Undergraduate Students in A Tertiary Care Hospital Type Journal Article
Year 2018 Publication Journal of Clinical & Experimental Ophthalmology Abbreviated Journal J Clin Exp Ophthalmol
Volume (down) 09 Issue 06 Pages
Keywords Human Health
Abstract Purpose: To evaluate the effect of late night study and excessive use of smart phones on the ocular health of medical undergraduate students.

Design: An observational and cross-sectional study.

Participants: Two hundred and fifty nine normal and healthy M.B.B.S students of age 18-25 y were included in the study over a period of two months.

Methods: All the volunteers underwent an interview in form of a questionnaire. A complete ophthalmic examination was done including snellen visual acuity assessment, anterior segment examination with slit lamp, posterior segment with direct or indirect ophthalmoscopy; Schirmer’s test and tear film break up time.

Results: A total of 259 subjects were included in the study and maximum subjects 160 (61.8%) were females. According to age, the students were divided in two groups as I and II with age of 17-20 y and 21-23 y respectively. Maximum 195 (75.3%) students belonged to group I. Maximum subjects 245 (94.5%) were using only smartphones and 239 (92.27%) subjects were using smartphones for more than 2 y. The maximum 136 (52.51%) students studied at night with maximum using tube light 112 (43.24%). A significant association was seen between the digital device used and age of the subject (p value=0.01). Number of symptoms experienced by the students showed significant relationship with the number of hours of smartphone usage (p value=0.02). Source of light in which the students studied at night was significantly associated with the number of symptoms experienced (p value=0.03). An association between usage of smartphones (hours) showed significant relationship with slit lamp examination (tear debri) and Schirmer’s (less than 15 mm) with p value of 0.03, 0.05 respectively.

Conclusion: Source of light used to study at night and number of hours of use of devices shows relationship with symptoms. Smart phone users showed computer-related eye problems in more than half of the subjects.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2155-9570 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2197
Permanent link to this record