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Author Russart, K.L.G.; Nelson, R.J. url  doi
openurl 
  Title Light at night as an environmental endocrine disruptor Type Journal Article
  Year 2018 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume (down) 190 Issue Pages 82-89  
  Keywords Human Health; Animals  
  Abstract Environmental endocrine disruptors (EEDs) are often consequences of human activity; however, the effects of EEDs are not limited to humans. A primary focus over the past approximately 30years has been on chemical EEDs, but the repercussions of non-chemical EEDs, such as artificial light at night (LAN), are of increasing interest. The sensitivity of the circadian system to light and the influence of circadian organization on overall physiology and behavior make the system a target for disruption with widespread effects. Indeed, there is increasing evidence for a role of LAN in human health, including disruption of circadian regulation and melatonin signaling, metabolic dysregulation, cancer risk, and disruption of other hormonally-driven systems. These effects are not limited to humans; domesticated animals as well as wildlife are also exposed to LAN, and at risk for disrupted circadian rhythms. Here, we review data that support the role of LAN as an endocrine disruptor in humans to be considered in treatments and lifestyle suggestions. We also present the effects of LAN in other animals, and discuss the potential for ecosystem-wide effects of artificial LAN. This can inform decisions in agricultural practices and urban lighting decisions to avoid unintended outcomes.  
  Address Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9384 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28870443 Approved no  
  Call Number LoNNe @ kyba @ Serial 1719  
Permanent link to this record
 

 
Author Cleary-Gaffney, M.; Coogan, A.N. url  doi
openurl 
  Title Limited evidence for affective and diurnal rhythm responses to dim light-at-night in male and female C57Bl/6 mice Type Journal Article
  Year 2018 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume (down) 189 Issue Pages 78-85  
  Keywords Animals  
  Abstract Circadian rhythms are recurring patterns in a range of behavioural, physiological and molecular parameters that display periods of near 24h, and are underpinned by an endogenous biological timekeeping system. Circadian clocks are increasingly recognised as being key for health. Environmental light is the key stimulus that synchronises the internal circadian system with the external time cues. There are emergent health concerns regarding increasing worldwide prevalence of electric lighting, especially man-made light-at-night, and light's impact on the circadian system may be central to these effects. A number of previous studies have demonstrated increased depression-like behaviour in various rodent experimental models exposed to dim light-at-night. In this study we set out to study the impact of dim light-at-night on circadian and affective behaviours in C57Bl/6 mice. We set out specifically to examine the impact of sex on light at night's effects, as well as the impact of housing conditions. We report minimal impact of light-at-night on circadian and affective behaviours, as measured by the tail suspension test, the forced swim test, the sucrose preference test and the elevated plus maze. Light-at-night was also not associated with an increase in body weight, but was associated with a decrease in the cell proliferation marker Ki-67 in the dentate gyrus. In summary, we conclude that experimental contextual factors, such as model species or strain, may be considerable importance in the investigation of the impact of light at night on mood-related parameters.  
  Address Department of Psychology, Maynooth University, National University of Ireland, Maynooth, Ireland. Electronic address: andrew.coogan@mu.ie  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9384 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29540316 Approved no  
  Call Number GFZ @ kyba @ Serial 1826  
Permanent link to this record
 

 
Author Hasler, B.P. url  doi
openurl 
  Title Commentary on Bedroom Light Exposure at Night and the Incidence of Depressive Symptoms: A Longitudinal Study of the HEIJOKYO Cohort (Obayashi et al) Type Journal Article
  Year 2018 Publication American Journal of Epidemiology Abbreviated Journal  
  Volume (down) 187 Issue 3 Pages 435-438  
  Keywords Commentary; Human Health  
  Abstract In modern society, we are increasingly disconnected from natural light/dark cycles and beset by round-the-clock exposure to artificial light. Light has powerful effects on physical and mental health, in part via the circadian system, and thus the timing of light exposure dictates whether it is helpful or harmful. In their compelling paper, Obayashi and colleagues offer evidence that light at night can prospectively predict an elevated incidence of depressive symptoms in older adults. Strengths of the study include the longitudinal design and direct, objective assessment of light levels, as well as accounting for multiple plausible confounders during analyses. Follow-up studies should address the study's limitations, including reliance on a global self-report of sleep quality and a two-night assessment of light exposure that may not reliably represent typical light exposure. In addition, experimental studies including physiological circadian measures will be necessary to determine if the light effects on depression are mediated through the circadian system or are so-called “direct” effects of light. In any case, these exciting findings could inform novel new approaches to preventing depressive disorders in older adults.  
  Address  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1716  
Permanent link to this record
 

 
Author Obayashi, K.; Saeki, K.; Kurumatani, N. url  doi
openurl 
  Title Obayashi et al. Respond to “Light at Night Predicts Depression—What Next?” Type Journal Article
  Year 2018 Publication American Journal of Epidemiology Abbreviated Journal  
  Volume (down) 187 Issue 3 Pages 439-440  
  Keywords Commentary; Human Health  
  Abstract Our research includes some strengths and limitations. The most important strength is objective measurement of light at night (LAN) intensity using a bedside light meter. Most previous studies evaluating the association between LAN and health outcomes have assessed indoor LAN levels using a self-reported questionnaire or outdoor LAN levels using satellite data; however, self-reported indoor LAN levels has not yet been validated with objective measurement and outdoor LAN levels are surrogates for an individual LAN exposure. The second strength of our study includes its longitudinal design using multivariable methods to adjust for confounders, which indicated LAN exposure may be a cause of the incidence of depressive symptoms. Indeed, the depressive score evaluated by questionnaires may be above or below the cut-off value over the short term; therefore, a long-term study considering such unstable outcomes should be conducted. In the current study, LAN exposure was measured for only two nights; thus, an amplitude of LAN intensity has been focused. However, multiple measurements over time in the future study would allow an analysis of fluctuations in LAN exposure, which might be important for circadian physiology.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1717  
Permanent link to this record
 

 
Author Obayashi, K.; Saeki, K.; Kurumatani, N. url  doi
openurl 
  Title Bedroom Light Exposure at Night and the Incidence of Depressive Symptoms: A Longitudinal Study of the HEIJO-KYO Cohort Type Journal Article
  Year 2018 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume (down) 187 Issue 3 Pages 427-434  
  Keywords Human Health; Mental Health; indoor light; geriatrics; Sleep; Sleep Disorders  
  Abstract Previous studies have indicated that minimal exposure to light at night (LAN) increases depression risk, even at 5 lux, in nocturnal and diurnal mammals. Although such low-level LAN may affect human circadian physiology, the association between exposure to LAN and depressive symptoms remains uncertain. In the present study, bedroom light intensity was measured objectively, and depressive symptoms were assessed, during 2010-2014 in Nara, Japan. Of 863 participants (mean age = 71.5 years) who did not have depressive symptoms at baseline, 73 participants reported development of depressive symptoms during follow-up (median, 24 months). Compared with the “dark” group (average of <5 lux; n = 710), the LAN group (average of >/=5 lux; n = 153) exhibited a significantly higher depression risk (hazard ratio = 1.89; 95% CI: 1.13, 3.14), according to a Cox proportional hazards model adjusting for age, sex, body mass index, and economic status. Further, the significance remained in a multivariable model adjusting for hypertension, diabetes, and sleep parameters (hazard ratio = 1.72; 95% CI: 1.03, 2.89). Sensitivity analyses using bedroom light data with a cutoff value of >/=10 lux suggested consistent results. In conclusion, these results indicated that exposure to LAN in home settings was independently associated with subsequent depression risk in an elderly general population.  
  Address Department of Community Health and Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashiharashi, Nara 634-8521, Japan; e-mail: obayashi(at)naramed-u.ac.jp  
  Corporate Author Thesis  
  Publisher Oxford Academic Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28992236 Approved no  
  Call Number IDA @ john @ Serial 1815  
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