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Author (up) Adams, C.A.; Blumenthal, A.; Fernández-Juricic, E.; Bayne, E.; St. Clair, C.C. url  doi
openurl 
  Title Effect of anthropogenic light on bird movement, habitat selection, and distribution: a systematic map protocol Type Journal Article
  Year 2019 Publication Environmental Evidence Abbreviated Journal Environ Evid  
  Volume 8 Issue S1 Pages  
  Keywords Animals  
  Abstract Anthropogenic light is known or suspected to exert profound effects on many taxa, including birds. Documentation of bird aggregation around artificial light at night, as well as observations of bird reactions to strobe lights and lasers, suggests that light may both attract and repel birds, although this assumption has yet to be tested. These effects may cause immediate changes to bird movement, habitat selection and settlement, and ultimately alter bird distribution at large spatial scales. Global increases in the extent of anthropogenic light contribute to interest by wildlife managers and the public in managing light to reduce harm to birds, but there are no evidence syntheses of the multiple ways light affects birds to guide this effort. Existing reviews usually emphasize either bird aggregation or deterrence and do so for a specific context, such as aggregation at communication towers and deterrence from airports. We outline a protocol for a systematic map that collects and organizes evidence from the many contexts in which anthropogenic light is reported to affect bird movement, habitat selection, or distribution. Our map will provide an objective synthesis of the evidence that identifies subtopics that may support systematic review and knowledge gaps that could direct future research questions. These products will substantially advance an understanding of both patterns and processes associated with the responses of birds to anthropogenic light.  
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  ISSN 2047-2382 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2547  
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Author (up) Admiranto, A.G.; Priyatikanto, R.; Maryam, S.; Ellyyani,; Suryana, N. url  doi
openurl 
  Title Preliminary Report of Light Pollution in Indonesia Based on Sky Quality Observation Type Journal Article
  Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.  
  Volume 1231 Issue Pages 012017  
  Keywords Skyglow  
  Abstract We observed night sky quality in several LAPAN stations (Agam, Bandung, Pontianak, Sumedang, Garut, Pasuruan, and Biak) which were conducted from April until July 2018 using Unihedron Sky Quality Meter LU-DL type. Observational data from all of the observational points were then sent regularly to a centralized database for further use. Although most of the measurements were done in overcast conditions, we were able to determine the representative clear sky brightness statistically. The results showed that the light pollution level of the most of the stations are moderate (the values at Biak, Agam, Sumedang, and Pontianak are 20.0, 19.5, 19.6, and 17.7 mpsas respectively) and the stations which are located near or in cities are high (Bandung and Pasuruan with 17.1 and 18.0 mpsas, respectively). In a particular station (Garut) the light pollution is low (20.6 mpsas), so it is good to make this spot to be a location of astrotourism.  
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  ISSN 1742-6588 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2570  
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Author (up) Agbaria, S.; Haim, A.; Fares, F.; Zubidat, A.E. url  doi
openurl 
  Title Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase Type Journal Article
  Year 2019 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages  
  Keywords Animals  
  Abstract Currently, one of the most disputed hypotheses regarding breast cancer (BC) development is exposure to short wavelength artificial light at night (ALAN) as multiple studies suggest a possible link between them. This link is suggested to be mediated by nocturnal melatonin suppression that plays an integral role in circadian regulations including cell division. The objective of the research was to evaluate effects of 1 x 30 min/midnight ALAN (134 micro Wcm(-2), 460 nm) with or without nocturnal melatonin supplement on tumor development and epigenetic responses in 4T1 tumor-bearing BALB/c mice. Mice were monitored for body mass (Wb) and tumor volume for 3 weeks and thereafter urine samples were collected at regular intervals for determining daily rhythms of 6-sulfatoxymelatonin (6-SMT). Finally, mice were sacrificed and the tumor, lungs, liver, and spleen were excised for analyzing the total activity of DNA methyltransferases (DNMT) and global DNA methylation (GDM) levels. Mice exposed to ALAN significantly reduced 6-SMT levels and increased Wb, tumor volume, and lung metastasis compared with controls. These effects were diminished by melatonin. The DNMT activity and GDM levels showed tissue-specific response. The enzymatic activity and GDM levels were lower in tumor and liver and higher in spleen and lungs under ALAN compared with controls. Our results suggest that ALAN disrupts the melatonin rhythm and potentially leading to increased BC burden by affecting DNMT activity and GDM levels. These data may also be applicable to early detection and management of BC by monitoring melatonin and GDM levels as early biomarker of ALAN circadian disruption.  
  Address b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa , Haifa , Israel; Zubidat3(at)013.net.il  
  Corporate Author Thesis  
  Publisher Taylor & Francis Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30746962 Approved no  
  Call Number IDA @ john @ Serial 2211  
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Author (up) Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L. url  doi
openurl 
  Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
  Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol  
  Volume in press Issue Pages  
  Keywords Vision  
  Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.  
  Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0340-5761 ISBN Medium  
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  Notes PMID:30778631 Approved no  
  Call Number GFZ @ kyba @ Serial 2229  
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Author (up) Anbalagan, M.; Dauchy, R.; Xiang, S.; Robling, A.; Blask, D.; Rowan, B.; Hill, S. url  doi
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  Title SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Type Journal Article
  Year 2019 Publication Journal of the Endocrine Society Abbreviated Journal  
  Volume 3 Issue Supplement_1 Pages  
  Keywords Animals  
  Abstract Breast cancer metastasis to bone is a major source of morbidity and mortality in women with advanced metastatic breast cancer. Morbidity from metastasis to bone is compounded by the fact that they cannot be surgically removed and can only be treated with chemotherapy and/or radiation therapy. Thus, there is critical need to develop new treatment strategies that kill bone metastatic tumors and reduce osteolytic lesions to improve patient quality of life and extend patient survival. Circadian rhythms are daily cycles of ~24 h that control many if not most physiologic processes and their disruption by exposure to light at night (LAN) or jet lag has been shown to be strongly associated with the development of cancer, particularly breast cancer. We have found that disruption of the anti-cancer circadian hormone melatonin (MLT) by light at night can significantly enhance the metastatic potential in breast cancer cells. Our work supports the report of the International Agency for Research on Cancer that shift work is a “probable human carcinogen” and highlights the association between exposure to light at night and invasive breast cancer. We recently reported that human breast tumor xenografts grown in athymic nude female rats housed in a photoperiod of 12h light at day: 12h dim light at night (dLAN, 0.2 lux – blocks the nighttime circadian MLT signal), display resistance to doxorubicin (Dox). More importantly, tumor growth and drug resistance could be blocked by the administration of Dox in circadian alignment with nocturnal MLT during dLAN. Our recent preliminary studies show that poorly invasive ERα positive MCF-7 breast cancer cells, when injected into the tibia (to mimic bone metastatic disease) of Foxn1nu athymic nude mice (which produce a strong circadian nighttime melatonin signal) housed in a dLAN photoperiod (suppressed nocturnal MLT production) developed full blown breast cancer tumors in bone (P<0.05) that are highly osteolytic (P<0.05). Moreover, patients with metastatic breast cancer are routinely treated with doxorubicin, which itself can promote bone damage. Our studies demonstrate that MLT slows the growth of metastatic breast cancer in bone but that the chrono-therapeutic use of doxorubicin in circadian alignment with melatonin in Foxn1nu mice with tibial breast tumors, reduced tumor growth in bone, reduced bone erosion, and promoted the formation of new bone. Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone.  
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  ISSN 2472-1972 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2433  
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