Artificial Light at Night (ALAN) Research Literature Database -- Query Results

Eisenstein, M. (2013). Chronobiology: stepping out of time. Nature, 497(7450), S10–2. Keywords: Human Health; Animals; Benzofurans/therapeutic use; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/genetics/physiology; Cyclopropanes/therapeutic use; Efficiency/physiology; Humans; Melatonin/agonists/metabolism; Obesity/metabolism; Sleep/genetics/physiology; Suprachiasmatic Nucleus/metabolism http://alandb.darksky.org/show.php?record=500
Garaulet, M., Ordovas, J. M., & Madrid, J. A. (2010). The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond), 34(12), 1667–1683. Abstract: The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. Finally, ideas about the use of chronobiology in the treatment of obesity are discussed. Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity. Keywords: Human Health; Animals; CLOCK Proteins/genetics/physiology; Circadian Rhythm/genetics/physiology; Energy Intake/physiology; Feeding Behavior/physiology; Humans; Mice; Motor Activity/physiology; Obesity/etiology/physiopathology; Sleep/physiology; Sleep Deprivation/complications/genetics/*physiopathology http://alandb.darksky.org/show.php?record=755
Sporl, F., Korge, S., Jurchott, K., Wunderskirchner, M., Schellenberg, K., Heins, S., et al. (2012). Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci U S A, 109(27), 10903–10908. Abstract: Circadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has been limited so far to mouse models, leaving the implication for human systems widely elusive. In particular, circadian rhythms in human skin, which is naturally exposed to strong daytime-dependent changes in the environment, have not been investigated to date on a molecular level. Here, we present a comprehensive analysis of circadian gene expression in human epidermis. Whole-genome microarray analysis of suction-blister epidermis obtained throughout the day revealed a functional circadian clock in epidermal keratinocytes with hundreds of transcripts regulated in a daytime-dependent manner. Among those, we identified a circadian transcription factor, Kruppel-like factor 9 (Klf9), that is substantially up-regulated in a cortisol and differentiation-state-dependent manner. Gain- and loss-of-function experiments showed strong antiproliferative effects of Klf9. Putative Klf9 target genes include proliferation/differentiation markers that also show circadian expression in vivo, suggesting that Klf9 affects keratinocyte proliferation/differentiation by controlling the expression of target genes in a daytime-dependent manner. Keywords: Human Health; Anti-Inflammatory Agents/pharmacology; Biological Clocks/genetics/physiology; Cell Differentiation/physiology; Cell Proliferation/drug effects; Cells, Cultured; Circadian Rhythm/genetics/physiology; Epidermis/cytology/physiology; Genome-Wide Association Study; Homeostasis/physiology; Humans; Hydrocortisone/pharmacology; Keratinocytes/cytology/drug effects/physiology; Kruppel-Like Transcription Factors/genetics/*metabolism; Luciferases/genetics; Skin Neoplasms/genetics/physiopathology http://alandb.darksky.org/show.php?record=814

Eisenstein, M. (2013). Chronobiology: stepping out of time. Nature, 497(7450), S10–2.

Garaulet, M., Ordovas, J. M., & Madrid, J. A. (2010). The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond), 34(12), 1667–1683.

Sporl, F., Korge, S., Jurchott, K., Wunderskirchner, M., Schellenberg, K., Heins, S., et al. (2012). Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci U S A, 109(27), 10903–10908.